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Pentadecapeptide BPC 157
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'''Pentadecapeptide BPC 157''', a fragment of gastric juice peptide BPC,<ref>{{Cite journal | last = Sikiric | first = Predrag | last2 = Seiwerth | first2 = Sven | last3 = Grabarevic | first3 = Zeljko | last4 = Petek | first4 = Marijan | last5 = Rucman | first5 = Rudolf | last6 = Turkovic | first6 = Branko | last7 = Rotkvic | first7 = Ivo | last8 = Jagic | first8 = Vjekoslav | last9 = Duvnjak | first9 = Marko | date = 1994-01-01 | title = The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides|url=http://www.sciencedirect.com/science/article/pii/0024320594007969|journal=Life Sciences|volume=54|issue=5|pages=PL63βPL68|doi=10.1016/0024-3205(94)00796-9|issn=0024-3205}}</ref> is derived from human [[Gastric acid|stomach acid]]. It is an experimental compound used in research for its potential applications in wound healing, [[collagen]] repair and [[angiogenesis]].<ref>{{Cite web|url=https://www.ingentaconnect.com/content/ben/cpd/2014/00000020/00000007/art00009 | title = BPC 157 and Blood Vessels | last = Seiwerth | first = Sven | last2 = Brcic | first2 = Luka | date = 2014 | website = ingentaconnect.com|language=en|access-date=2019-06-24 | last3 = Batelja Vuletic | first3 = Lovorka | last4 = Kolenc | first4 = Danijela | last5 = Aralica | first5 = Gorana | last6 = Misic | first6 = Marija | last7 = Zenko | first7 = Anita | last8 = Drmic | first8 = Domagoj | last9 = Rucman | first9 = Rudolf}}</ref> BPC 157 improved wound healing in rats with muscle crush injury and contusions, and quadricep transection,<ref>{{Cite journal | last = Staresinic | first = Mario | last2 = Petrovic | first2 = Igor | last3 = Novinscak | first3 = Tomislav | last4 = Jukic | first4 = Ivana | last5 = Pevec | first5 = Damira | last6 = Suknaic | first6 = Slaven | last7 = Kokic | first7 = Neven | last8 = Batelja | first8 = Lovorka | last9 = Brcic | first9 = Luka | date = 2006 | title=Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157|url=https://onlinelibrary.wiley.com/doi/abs/10.1002/jor.20089|journal=Journal of Orthopaedic Research|language=en|volume=24|issue=5|pages=1109β1117|doi=10.1002/jor.20089|issn=1554-527X}}</ref><ref name=":0">{{Cite journal | last = Staresinic | first = Mario | last2 = Petrovic | first2 = Igor | last3 = Novinscak | first3 = Tomislav | last4 = Jukic | first4 = Ivana | last5 = Pevec | first5 = Damira | last6 = Suknaic | first6 = Slaven | last7 = Kokic | first7 = Neven | last8 = Batelja | first8 = Lovorka | last9 = Brcic | first9 = Luka | date = 2006 | title=Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157|url=https://onlinelibrary.wiley.com/doi/abs/10.1002/jor.20089|journal=Journal of Orthopaedic Research|language=en|volume=24|issue=5|pages=1109β1117|doi=10.1002/jor.20089|issn=1554-527X}}</ref> even in the presence of corticosteroids (which impair wound healing).<ref name=":0" /> It has also demonstrated efficacy in experimental ulcer models<ref>{{Cite journal | last = Sikiric | first = Predrag | last2 = Seiwerth | first2 = Sven | last3 = Grabarevic | first3 = Zeljko | last4 = Petek | first4 = Marijan | last5 = Rucman | first5 = Rudolf | last6 = Turkovic | first6 = Branko | last7 = Rotkvic | first7 = Ivo | last8 = Jagic | first8 = Vjekoslav | last9 = Duvnjak | first9 = Marko | date = 1994-01-01 | title = The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides|url=http://www.sciencedirect.com/science/article/pii/0024320594007969|journal=Life Sciences|volume=54|issue=5|pages=PL63βPL68|doi=10.1016/0024-3205(94)00796-9|issn=0024-3205}}</ref> and models of traumatic nerve injury.<ref>{{Cite journal | last = Gjurasin | first = Miroslav | last2 = Miklic | first2 = Pavle | last3 = Zupancic | first3 = Bozidar | last4 = Perovic | first4 = Darko | last5 = Zarkovic | first5 = Kamelija | last6 = Brcic | first6 = Luka | last7 = Kolenc | first7 = Danijela | last8 = Radic | first8 = Bozo | last9 = Seiwerth | first9 = Sven | date = 2010-02-25 | title = Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury|url=http://www.sciencedirect.com/science/article/pii/S0167011509002274|journal=Regulatory Peptides|volume=160|issue=1|pages=33β41|doi=10.1016/j.regpep.2009.11.005|issn=0167-0115}}</ref> It has been shown to increase expression of many types of growth factors<ref>{{Cite web|url=https://www.ingentaconnect.com/content/ben/cpd/2018/00000024/00000018/art00009 | title = BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing | last = Seiwerth | first = Sven | last2 = Rucman | first2 = Rudolf | date = 2018 | website = ingentaconnect.com|language=en|access-date=2019-09-11 | last3 = Turkovic | first3 = Branko | last4 = Sever | first4 = Marko | last5 = Klicek | first5 = Robert | last6 = Radic | first6 = Bozo | last7 = Drmic | first7 = Domagoj | last8 = Stupnisek | first8 = Mirjana | last9 = Misic | first9 = Marija}}</ref><ref name=":1">{{Cite journal | last = Pang | first = Jong-Hwei Su | last2 = Hsu | first2 = Ya-Hui | last3 = Tsai | first3 = Wen-Chung | last4 = Chang | first4 = Chung-Hsun | date = Nov 2014 | title = Pentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts|url=https://www.mdpi.com/1420-3049/19/11/19066|journal=Molecules|language=en|volume=19|issue=11|pages=19066β19077|doi=10.3390/molecules191119066|pmc=|pmid=|quote=|access-date=|via=}}</ref><ref name=":2">{{Cite journal | last = Hsieh | first = Ming-Jer | last2 = Liu | first2 = Hsien-Ta | last3 = Wang | first3 = Chao-Nin | last4 = Huang | first4 = Hsiu-Yun | last5 = Lin | first5 = Yuling | last6 = Ko | first6 = Yu-Shien | last7 = Wang | first7 = Jong-Shyan | last8 = Chang | first8 = Vincent Hung-Shu | last9 = Pang | first9 = Jong-Hwei S. | date = 2017-03-01 | title = Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation | url =https://doi.org/10.1007/s00109-016-1488-y|journal=Journal of Molecular Medicine|language=en|volume=95|issue=3|pages=323β333|doi=10.1007/s00109-016-1488-y|issn=1432-1440}}</ref> including [[growth hormone receptor]]<ref name=":1" /> and [[vascular endothelial growth factor]]<ref name=":2" /> (VEGF) expression on [[Fibroblast|fibroblasts]]. == References == {{Reflist}} [[Category:Peptides]] [[Category:Potential treatments]]
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