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Patricia Kane protocol
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==Evidence== There have been no clinical trials of the PK protocol for the treatment of any disease. Some of the individual components of the protocol have been studied. ===Sodium phenylbutyrate=== In mouse models of Parkinson's, sodium phenylbutyrate was found to protect the loss of [[dopamine]]rgic neurons.<ref>{{Cite journal | last = Iannitti | first = Tommaso | author-link = | last2 = Palmieri | first2 = Beniamino | authorlink2 = | date = Sep 2011 | title = Clinical and Experimental Applications of Sodium Phenylbutyrate|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586072/|journal=Drugs in R&D|volume=11|issue=3|pages=227–249|doi=10.2165/11591280-000000000-00000|issn=1174-5886|pmc=3586072|pmid=21902286|access-date=|quote=|via=}}</ref><ref>{{Cite journal | last = Freed | first = Curt R. | last2 = Lebin | first2 = Jacob | last3 = Luong | first3 = Nancy | last4 = Cummiskey | first4 = Jessica | last5 = Bercury | first5 = Kathryn | last6 = Zhou | first6 = Wenbo | date = 2011-04-29 | title = Phenylbutyrate Up-regulates the DJ-1 Protein and Protects Neurons in Cell Culture and in Animal Models of Parkinson Disease|url=http://www.jbc.org/content/286/17/14941|journal=Journal of Biological Chemistry|language=en|volume=286|issue=17|pages=14941–14951|doi=10.1074/jbc.M110.211029|issn=0021-9258|pmid=21372141}}</ref><ref>{{Cite journal | last = Pahan | first = Kalipada | last2 = Gendelman | first2 = Howard E. | last3 = Brahmachari | first3 = Saurav | last4 = Liu | first4 = Xiaojuan | last5 = Jana | first5 = Arundhati | last6 = Ghosh | first6 = Anamitra | last7 = Roy | first7 = Avik | date = 2012-06-18 | title = Sodium Phenylbutyrate Controls Neuroinflammatory and Antioxidant Activities and Protects Dopaminergic Neurons in Mouse Models of Parkinson’s Disease|url=https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0038113|journal=PLOS ONE|language=en|volume=7|issue=6| pages = e38113|doi=10.1371/journal.pone.0038113|issn=1932-6203|pmc=3377667|pmid=22723850}}</ref>
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