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Omega 3 fatty acid hypothesis
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===Effects of fatty acid treatment=== The evidence for fatty acid treatment is mixed, owing in part to varying research criteria and incomparable treatments. A double-blind, placebo-controlled study of 63 patients with [[postviral fatigue syndrome]] found the 85% of patients found improvement at three months on Efamol Marine, a high Omega-6 formulation of evening primrose oil and fish oil (linoleic acid: 58%, GLA: 7.2%, EPA: 3.6%, and DHA: 2.4%) .<ref>onlinelibrary.wiley.com/doi/10.1111/j.1600-0404.1990.tb04490.x/abstract</ref> An attempt to replicate the study using Efamol Marine and the Oxford Criteria found no effect.<ref>http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0404.1999.tb00667.x/abstract</ref> In a small case study of four patients diagnosed by the [[Fukuda criteria]], Puri found that high dose EPA was associated with significant improvement after 12 weeks of treatment.<ref>http://www.sciencedirect.com/science/article/pii/S0952327804000122</ref>
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