General category
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Year of publication
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Study title
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Author(s)
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Notes
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Cohort size
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Blinded (double, single, not)
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Epidemiological |
2015 |
Institute of Medicine report |
Ellen Wright Clayton (Chair), Margarita Alegría, Lucinda Bateman, Lily Chu, Charles Cleeland, Ronald Davis, Betty Diamond, Theodore Ganiats, Betsy Keller, Nancy Klimas, A Martin Lerner, Cynthia Mulrow, Benjamin Natelson, Peter Rowe, Michael Shelanski |
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Epidemiological |
2015 |
Pathways to prevention report |
Green CR, Cowan P, Elk R, O'Neil KM, Rasmussen AL |
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Epidemiological |
2014 |
Two age peaks in the incidence of chronic fatigue syndrome/myalgic encephalomyelitis: a population-based registry study from Norway 2008–2012 |
Bakken IJ, Tveito K, Gunnes N, Ghaderi S, Stoltenberg C, Trogstad L, Håberg SE, Magnus P |
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Epidemiological |
2013 |
The prevalence of chronic fatigue syndrome/myalgic encephalomyelitis: a meta-analysis |
Samantha Johnston, Ekua Brenu, Donald Staines, Sonya Marshall-Gradisnik |
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Epidemiological |
2011 |
Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care |
Luis Nacul, Eliana Lacerda, Derek Pheby, Peter Campion, Mariam Molokhia, Shagufta Fayyaz, Jose CDC Leite, Fiona Poland, Amanda Howe, Maria L Drachler |
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Epidemiological |
2007 |
The burden of disease and injury in Australia 2003 |
Stephen Begg, Theo Vos, Barker B, Stevenson C, Stanley L, Lopez A |
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Epidemiological |
2006 |
Prolonged Illness after infectious mononucleosis is associated with altered immunity but not with increased viral load |
Cameron, B., Bharadwaj, M., Burrows, J., Fazou, C., Wakefield, D., Hickie, I., Ffrench, R., Khanna, R. and Lloyd A. |
See also Model of Post Infective Fatigue Forming: the Dubbo Studies |
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Epidemiological |
2006 |
Preliminary evidence of mitochondrial dysfunction associated with post-infective fatigue after acute infection with Epstein Barr virus |
Vernon, S., Whistler, T., Cameron, B., Hickie, I., Reeves, W. and Lloyd A. |
See also Model of Post Infective Fatigue Forming: the Dubbo Studies |
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Epidemiological |
2006 |
Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study |
Ian Hickie, Tracey Davenport, Denis Wakefield, Vollmer-Conna U, Cameron B, Vernon SD, Reeves WC, Lloyd A |
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Epidemiological |
2005 |
A systematic review describing the prognosis of chronic fatigue syndrome |
Ruth Cairns, Matthew Hotopf |
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Epidemiological |
1996 |
Health status in patients with chronic fatigue syndrome and in general population and disease comparison groups |
Anthony Komaroff, Fagioli LR, Doolittle TH, Gandek B, Gleit MA, Guerriero RT, Kornish RJ 2nd, Ware NC, Ware JE Jr, Bates DW |
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Immunological |
2015 |
Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome |
Landi A, Broadhurst D, Suzanne Vernon, Tyrrell DL, Houghton M |
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Immunological |
2015 |
Distinct plasma immune signatures in ME/CFS are present early in the course of illness |
Mady Hornig, Jose Montoya, Nancy Klimas, Levine S, Felsenstein D, Lucinda Bateman, Daniel Peterson, Gottschalk CG, Schultz AF, Che X, Eddy ML, Anthony Komaroff, Ian Lipkin |
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Immunological |
2014 |
Deficient EBV-specific B-and T-cell response in patients with chronic fatigue syndrome |
Madlen Loebel, Kristin Strohschein, Carolin Giannini, Uwe Koelsch, Sandra Bauer, Cornelia Doebis, Sybill Thomas, Nadine Unterwalder, Volker von Baehr, Petra Reinke, Michael Knops, Leif G. Hanitsch, Christian Meisel, Hans-Dieter Volk, Carmen Scheibenbogen |
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Immunological |
2012 |
Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome/myalgic encephalomyelitis |
Ekua Brenu, Mieke L van Driel, Donald Staines, Kevin J Ashton, Sharni L Hardcastle, James Keane, Lotti Tajouri, Daniel Peterson, Sandra B Ramos, Sonya Marshall-Gradisnik |
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Immunological |
2011 |
Benefit from B-lymphocyte depletion using the anti-CD20 antibody rituximab in chronic fatigue syndrome. A double-blind and placebo-controlled study |
Øystein Fluge , Ove Bruland, Kristin Risa, Anette Storstein, Einar K. Kristoffersen, Dipak Sapkota, Halvor Næss, Olav Dahl, Harald Nyland, Olav Mella |
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Immunological |
2010 |
Biomarkers in chronic fatigue syndrome: evaluation of natural killer cell function and dipeptidyl peptidase IV/CD26 |
Fletcher MA, Zeng XR, Maher K |
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Immunological |
2008 |
Neuroendocrine and immune network remodeling in chronic fatigue syndrome: an exploratory analysis |
Fuite J, Suzanne Vernon, Gordon Broderick |
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Immunological |
2008 |
Cytokine Polymorphisms Have a Synergistic Effect on Severity of the Acute Sickness Response to Infection |
Vollmer-Conna U, Piraino B, Cameron B |
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Immunological |
2007 |
Postinfective fatigue syndrome is not associated with altered cytokine production |
Vollmer-Conna U, Cameron B, Pavlovic D |
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Immunological |
2006 |
A first study of cytokine genomic polymorphisms in CFS: positive association of TNF‐857 and IFNgamma 874 rare alleles |
Carlo‐Stella N, Badulli C, De S |
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Immunological |
2005 |
Association of chronic fatigue syndrome with human leucocyte antigen class II alleles |
Smith J, Fritz EL, Jonathan Kerr |
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Metabolic |
2016 |
Metabolic features of chronic fatigue syndrome |
Ronald Davis (Editor), Robert Naviaux, Jane C. Naviaux, Kefeng Li, A. Taylor Bright, William A. Alaynick, Lin Wang, Asha Baxter, Neil Nathan, Wayne Anderson, Eric Gordon |
Metabolomics showed that chronic fatigue syndrome is a highly concerted hypometabolic response to environmental stress that traces to mitochondria and was similar to the classically studied developmental state of dauer. |
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Metabolic |
2014 |
Inability of myalgic encephalomyelitis/chronic fatigue syndrome patients to reproduce VO2peak indicates functional impairment |
Betsy Keller, John Pryor, Ludovic Giloteaux |
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Metabolic |
2012 |
Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls |
AT White, Alan Light, RW Hughen, TA Vanhaitsma, Kathleen Light |
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Metabolic |
2009 |
Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects |
Alan Light, AT White, RW Hughen, Kathleen Light |
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Neurological |
2016 |
Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study. |
Shan ZY, Richard Kwiatek, Burnet R, Del Fante P, Donald Staines, [[Sonya Marshall-Gradisnik]], Barnden LR. |
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Neurological |
2015 |
Phase relationships are only measurable by the qEEG, giving us a unique window into the ME disease process |
Marcie Zinn, Mark Zinn, Leonard Jason |
See also [Phase Reset of the Default Mode Network. |
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Neurological |
2015 |
There is poor agreement among researchers and clinicians about case definitions. Key domains are discussed. |
Leonard Jason, Marcie Zinn, Mark Zinn |
See also Lack of Agreement in Case Definitions hampers research. |
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Neurological |
2015 |
Right arcuate fasciculus abnormality in chronic fatigue syndrome |
Michael Zeineh, Kang J, Atlas SW, Raman MM, Reiss AL, Jane Norris, Valencia I, Jose Montoya |
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Neurological |
2007 |
Symptoms of autonomic dysfunction in chronic fatigue syndrome |
Julia Newton, O Okonkwo, K Sutcliffe, Seth A, Shin J, Jones DE |
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Treatment |
2015 |
Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome |
Øystein Fluge, Olav Mella, Loebel M, Grabowski P, Heidecke H, Bauer S, Hanitsch LG, Wittke K, Meisel C, Reinke P, Volk HD, Carmen Scheibenbogen |
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Treatment |
2015 |
B-Lymphocyte Depletion in Myalgic Encephalopathy/ Chronic Fatigue Syndrome. An Open-Label Phase II Study with Rituximab Maintenance Treatment |
Øystein Fluge, Olav Mella, Risa K, Lunde S, Alme K, Rekeland IG, Sapkota D, Kristoffersen EK, Sørland K, Bruland O, Dahl O |
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Treatment |
2013 |
Altered functional B cell subset populations in patients with chronic fatigue syndrome compared to healthy controls |
Amolak Bansal, AS Bradley, B Ford |
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Treatment |
2013 |
Fibromyalgia Symptoms Are Reduced by Low-Dose Naltrexone: A Pilot Study |
Jarred Younger, Sean Mackey |
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Treatment |
2012 |
The GI Microbiome and its Role in Chronic Fatigue Syndrome: A Summary of Bacteriotherapy |
Thomas J. Borody, Anna Nowak, Sarah Finalayson |
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Treatment |
2011 |
Benefit from B-lymphocyte depletion using the anti-CD20 antibody rituximab in chronic fatigue syndrome. A double-blind and placebo-controlled study |
Øystein Fluge, Olav Mella, Bruland O, Risa K, Storstein A, Kristoffersen EK, Sapkota D, Næss H, Dahl O, Nyland H |
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Treatment |
2010 |
Low-dose naltrexone for the treatment of fibromyalgia: findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels |
Jarred Younger, Noor N, McCue R, Mackey S |
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Treatment |
2009 |
Clinical impact of B-cell depletion with the anti-CD20 antibody rituximab in chronic fatigue syndrome: a preliminary case series |
Øystein Fluge, Olav Mella |
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Treatment |
2008 |
Normalization of leaky gut in Chronic Fatigue Syndrome (CFS) is accompanied by a clinical improvement |
Michael Maes, Jean-Claude Leunis |
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Psychological |
2011 |
The PACE trial |
Peter White, KA Goldsmith, AL Johnson, L Potts, R Walwyn, JC DeCesare, HL Baber, M Burgess, LV Clark, DL Cox, Jessica Bavinton, BJ Angus, Gabrielle Murphy, M Murphy, H O'Dowd, D Wilks, P McCrone, Trudie Chalder, Michael Sharpe |
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Psychological |
2005 |
The Placebo Response in the Treatment of Chronic Fatigue Syndrome: A Systematic Review and Meta-Analysis |
Hyong Jin Cho, Matthew Hotopf, Simon Wessely |
Found that the placebo response was actually lower in CFS patients |
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Psychological |
2014 |
Exercise therapy for chronic fatigue syndrome |
Cochrane: Lillebeth Larun, Kjetil G. Brurberg, Jan Odgaard-Jensen, Jonathan R Price |
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