Nitric oxide hypothesis
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Nitric oxide hypothesis
Theory[edit | edit source]
Dr Martin Pall states: "I propose here a novel hypothesis of CFS in which either viral or bacterial infection induces one or more cytokines, IL-1beta IL-6, TNF-alpha and IFN-gamma. These induce nitric oxide synthase (iNOS), leading to increased nitric oxide levels. Nitric oxide, in turn, reacts with superoxide radical to generate the potent oxidant peroxynitrite. Multiple amplification and positive feedback mechanisms are proposed by which once peroxynitrite levels are elevated, they tend to be sustained at a high level."[1]
Evidence[edit | edit source]
Learn more[edit | edit source]
- How Can We Cure NO/ONOO− Cycle Diseases?, Martin L. Pall, 2010
- Nitric oxide and its possible implication in ME/CFS (Part 1 of 2), Phoenix Rising, August 25, 2014
- Nitric oxide and its possible implication in ME/CFS (Part 2 of 2), Phoenix Rising, August 28, 2014
- Fluge/Mella Take out Patent on Nitric Oxide Treatment for ME/CFS, Health Rising, 31 Jul 2015
See also[edit | edit source]
References[edit | edit source]
- ↑ Pall, ML. (2000). Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome. Medical Hypotheses, 54 (1):115-25. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/10790736
