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Nitric oxide hypothesis
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==Theory== Dr [[Martin Pall|Martin L. Pall]] states: "I propose here a novel hypothesis of [[Chronic fatigue syndrome|CFS]] in which either viral or bacterial [[infection]] induces one or more [[Cytokine|cytokines]], [[Interleukin 1|IL-1beta]] [[Interleukin 6|IL-6]], [[TNF-alpha]] and [[IFN-gamma]]. These induce [[nitric oxide]] synthase (iNOS), leading to increased nitric oxide levels. Nitric oxide, in turn, reacts with [[superoxide radicals]] to generate the potent oxidant [[peroxynitrite]]. Multiple amplification and positive feedback mechanisms are proposed by which once peroxynitrite levels are elevated, they tend to be sustained at a high level."<ref>{{Cite journal | last = Pall | first = Martin L. | authorlink = Martin Pall | date = Jan 2000 | title = Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/10790736|journal=Medical Hypotheses|volume=54|issue=1|pages=115β125|doi=10.1054/mehy.1998.0825|issn=0306-9877|pmid=10790736|quote=|via=}}</ref>
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