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Nimodipine
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{{stub}} '''Nimodipine''', also known under the brand name '''nimotop''',<ref>{{Cite web|url=https://www.rxlist.com/nimotop-drug.htm | title = Nimotop (Nimodipine): Uses, Dosage, Side Effects, Interactions, Warning|website=RxList|language=en|access-date=2020-08-29}}</ref> is a [[calcium channel blocker]] typically used for ischemic stroke, [[migraine]] prevention and subarachnoid hemorhage.<ref name="drugbank">{{Cite web|url=https://www.drugbank.ca/drugs/DB00393 | title = Nimodipine | website = drugbank.ca|access-date=2020-08-28}}</ref><ref name="drugscom">{{Cite web|url=https://www.drugs.com/international/nimodipine.html | title = Nimodipine|website=Drugs.com|language=en|access-date=2020-08-28}}</ref> ==Evidence == Evidence for the use of nimodipine in patients with ME/CFS is extremely limited, mostly based on personal experiences rather than clinical trials, and with mixed results reported in patients. In 1996, Dr Ellen Wiebe published case studies of two patients with ME/CFS, including a moderately ill patient who noticed improvements in [[fatigue]], [[cognitive dysfunction|cognitive function]] and [[myalgia|muscle pain]] after starting nimodipine.<ref name="PMC2146911">{{Cite journal | last = Wiebe | first = E. | authorlink = | date = Nov 1996 | title = N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2146911/|journal=Canadian Family Physician|volume=42|issue=|pages=2214β2217|doi=|issn=0008-350X|pmc=2146911|pmid=8939323|access-date=|quote=|via=}}</ref> In 1998, three British doctors with a special interest in ME/CFS, stated that in their experience nimodipine and other calcium channel blockers were ineffective in patients chronic fatigue syndrome.<ref name="rcp1998">{{Cite journal|url = https://www.rcpe.ac.uk/sites/default/files/vol28_2.1_1.pdf | last = Chaudhuri | first = A | authorlink = Abhijit Chaudhuri | last2 = Behan | first2 = WMH | last3 =Behan | first3 = PO | authorlink3 = Peter Behan | title = Chronic fatigue syndrome|journal=Proc R Coll Physic Edinb | date = 1998 | volume=28|pages=150-163}}</ref> ==Notable studies == *1996, [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2146911/ N of 1 trials: Managing patients with chronic fatigue syndrome: two case reports] ==Articles and blogs== *2016, [https://25megroup.org/download/1780/?v=2673 NIMODIPINE use in ME/CFS: An introduction] - Susan Parker *2014 [https://drive.google.com/file/d/1u7ddtC_NuyLLJiqkUcb4x6akvW80WLYJ/view?usp=sharing Nimopidine use in ME/CFS: A comprehensive guide]- Susan Parker *Jan 28, 2008, [https://meassociation.org.uk/2008/01/brief-notes-on-nimodipine-and-mecfs/ Brief notes on Nimodipine and ME/CFS] - M.E. Association ==Learn more== *[https://www.drugbank.ca/drugs/DB00393 Nimodipine] - drugbank.ca *[https://www.drugs.com/international/nimodipine.html Nimodipine] - drugs.com ==See also== *[[Migraine]] *[[Calcium channel blocker]] *[[Channelopathy]] ==References== {{Reflist}} [[Category:Calcium channel blockers]] [[Category:Potential treatments]]
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