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Natural killer cell
(section)
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==== Causes ==== The following mechanisms have some degree of evidence that they cause NK dysfunction in ME: * '''Altered MAPK signaling'''.<ref name="Chacko, 2016" /><ref name=":0" /> * '''Calcium channel dysfunction'''.<ref>{{Cite journal|title=Impaired TRPM3-dependent calcium influx and restoration using Naltrexone in natural killer cells of myalgic encephalomyelitis/chronic fatigue syndrome patients|date=2022-02-16|url=https://doi.org/10.1186/s12967-022-03297-8|journal=Journal of Translational Medicine|volume=20|issue=1|pages=94|last=Eaton-Fitch|first=Natalie|last2=Du Preez|first2=Stanley|last3=Cabanas|first3=Hélène|last4=Muraki|first4=Katsuhiko|last5=Staines|first5=Donald|last6=Marshall-Gradisnik|first6=Sonya|doi=10.1186/s12967-022-03297-8|pmc=PMC8848670|pmid=35172836|issn=1479-5876}}</ref> * '''MicroRNAs'''. Transfecting primary NK cells with microRNAs that were upregulated in ME, resulted in gene expression changes consistent with NK cell activation but diminished cytotoxicity.<ref name="PettyD2016" />
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