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==Notable studies== *May 2019, Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients<ref>{{Cite journal | last = Cabanas | first = H. | authorlink = Hélène Cabanas | last2 = Muraki | first2 = K. | authorlink2 = Katsuhiko Muraki | last3 = Balinas | first3 = C. | authorlink3 = Cassandra Balinas | last4 = Eaton-Fitch | first4 = N. | authorlink4 = Natalie Eaton-Fitch | last5 = Staines | first5 = D. | authorlink5 = Donald Staines | last6 = Marshall-Gradisnik | first6 = S. | authorlink6 = Sonya Marshall-Gradisnik | date = 2019-04-23 | title = Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480905/|journal=[[Molecular Medicine]]|volume=25|issue=|pages=|doi=10.1186/s10020-019-0083-4|issn=1076-1551|pmc=6480905|pmid=31014226|quote=|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480905/ (Full text)] *Aug 2018, Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients<ref name="Cabanas2018">{{Cite journal | last = Cabanas | first = Hélène | authorlink = Hélène Cabanas | last2 = Muraki | first2 = Katsuhiko | authorlink2 = Katsuhiko Muraki | last3 = Eaton | first3 = Natalie | author-link3 = Natalie Eaton-Fitch | last4 = Balinas | first4 = Cassandra | authorlink4 = Cassandra Balinas | last5 = Staines | first5 = Donald | authorlink5 = Donald Staines | last6 = Marshall-Gradisnik | first6 = Sonya | authorlink6 = Sonya Marshall-Gradisnik | date = 2018-08-14 | title = Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092868/|journal=[[Molecular Medicine]]|volume=24|issue=|pages=|doi=10.1186/s10020-018-0046-1|issn=1076-1551|pmc=6092868|pmid=30134818|quote=|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092868/#__ffn_sectitle (Full text)] *May 2016, [https://biolres.biomedcentral.com/articles/10.1186/s40659-016-0087-2 Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients]<ref name="TRPM3-2016">{{Cite journal | last = Nguyen | first = T. | authorlink = Thao Nguyen | last2 = Staines | first2 = D. | authorlink2 = Donald Staines | last3 = Nilius | first3 = B. | authorlink3 = B Nilius | last4 = Smith | first4 = P. | authorlink4 = Peter Smith | last5 = Marshall-Gradisnik | first5 = S. | authorlink5 = Sonya Marshall-Gradisnik | date = 2016-05-31 | title = Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients|url=https://doi.org/10.1186/s40659-016-0087-2|journal=[[Biological Research (journal)|Biological Research]]|volume=49|issue=1|pages=27|doi=10.1186/s40659-016-0087-2|issn=0717-6287|pmc=4888729|pmid=27245705|quote=|via=}}</ref> (Full text) *Apr 2016, [http://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0859-z ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56dimCD16+ and CD56brightCD16dim/− natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients]<ref name="Huth2016">{{Cite journal | last = Huth | first = Teilah Kathryn | authorlink = Teilah Huth | last2 = Staines | first2 = Donald | authorlink2 = Donald Staines | last3 = Marshall-Gradisnik | first3 = Sonya | authorlink3 = Sonya Marshall-Gradisnik | authorlink4 = | authorlink5 = | date = 2016-04-21 | title = ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56dimCD16+ and CD56brightCD16dim/− natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients|url=https://doi.org/10.1186/s12967-016-0859-z|journal=[[Journal of Translational Medicine]]|volume=14|issue=1 | pages = 97|doi=10.1186/s12967-016-0859-z|issn=1479-5876|pmc=4839077|pmid=27098723|quote=|via=}}</ref> (Full text) *Jan 2016, [https://journals.sagepub.com/doi/full/10.4137/III.S37042 Genotype Frequencies of Transient Receptor Potential Melastatin M3 Ion Channels and Acetylcholine Muscarinic M3 Receptor Gene Polymorphisms in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients Genotype Frequencies of Transient Receptor Potential Melastatin M3 Ion Channels and Acetylcholine Muscarinic M3 Receptor Gene Polymorphisms in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients]<ref name="Genotype-2016">{{Cite journal | last = Marshall-Gradisnik | first = S.M. | authorlink = Sonya Marshall-Gradisnik | last2 = Chacko | first2 = A. | authorlink2 = A Chacko | last3 = Johnston | first3 = S. | authorlink3 = Samantha Johnston | last4 = Smith | first4 = P. | authorlink4 = Peter Smith | last5 = Nilius | first5 = B. | authorlink5 = B Nilius | last6 = Staines | first6 = D.R. | authorlink6 = Donald Staines | date = 2016-01-01 | title = Genotype Frequencies of Transient Receptor Potential Melastatin M3 Ion Channels and Acetylcholine Muscarinic M3 Receptor Gene Polymorphisms in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients|url=https://doi.org/10.4137/III.S37042|journal=Immunology and Immunogenetics Insights|language=en|volume=8|issue=|pages=III.S37042|doi=10.4137/III.S37042|issn=1178-6345|quote=|via=}}</ref> [https://journals.sagepub.com/doi/full/10.4137/III.S37042 (Full text)] *Dec 2015, [http://www.hindawi.com/journals/jir/2016/9064529/abs/ A Preliminary Comparative Assessment of the Role of CD8+ T Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis]<ref name="CD8+2015">{{Cite web|url=https://www.hindawi.com/journals/jir/2016/9064529/abs/ | title = A Preliminary Comparative Assessment of the Role of CD8 | last = Marshall-Gradisnik | first = Sonya | authorlink=Sonya Marshall-Gradisnik | last2 = Staines | first2 = Don | authorlink2 = Donald Staines | date = 2016 | website = [[Journal of Immunology Research]]|language=en|archive-url=|archive-date=|url-status=|access-date=2019-05-10 | last3 = Ramos | first3 = Sandra | authorlink3 = Sandra Ramos | last4 = Johnston | first4 = Samantha | authorlink4 = Samantha Johnston | last5 = Nguyen | first5 = Thao | authorlink5 = Thao Nguyen | last6 = Broadley | first6 = Simon | authorlink6 = Simon Broadley | last7 = Brenu | first7 = Ekua W. | authorlink7 = Ekua Brenu}}</ref> (Full text) *Dec 2015, [http://onlinelibrary.wiley.com/doi/10.1111/sji.12388/abstract Pilot Study of Natural Killer Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis]<ref name="NKcells-2015">{{Cite journal | last = Huth | first = T.K. | authorlink = Teilah Huth | last2 = Brenu | first2 = E.W. | authorlink2 = Ekua Brenu | last3 = Ramos | first3 = S. | authorlink3 = Sandra Ramos | last4 = Nguyen | first4 = T. | authorlink4 = Thao Nguyen | last5 = Broadley | first5 = S. | authorlink5 = Simon Broadley | last6 = Staines | first6 = D. | authorlink6 = Donald Staines | last7 = Marshall‐Gradisnik | first7 = S. | authorlink7 = Sonya Marshall-Gradisnik | date = 2016 | title=Pilot Study of Natural Killer Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/sji.12388|journal=[[Scandinavian Journal of Immunology]]|language=en|volume=83|issue=1 | pages = 44–51|doi=10.1111/sji.12388|issn=1365-3083|quote=|via=}}</ref> (Abstract) *Sep 2015, [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615236/ Serum Immune Proteins in Moderate and Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients], ''Int J Med Sci'', 2015; 12(10): 764–772. *Aug 2015, [http://translational-medicine.biomedcentral.com/articles/10.1186/s12967-015-0653-3 Longitudinal analysis of immune abnormalities in varying severities of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients], ''Journal of Translatqional Medicine'', 201513:299 **Conclusions: [[Severe and very severe ME|Severe CFS/ME patients]] differed from controls and moderate CFS/ME patients over time and expressed significant alterations in iNKT cell phenotypes, CD8+T cell markers, NK cell receptors and γδT cells at 6 months. *May 2015 - [http://bmcimmunol.biomedcentral.com/articles/10.1186/s12865-015-0101-4 Characterisation of cell functions and receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)], ''BMC Immunology'', 2015 16:35 *May 2015 - [http://www.la-press.com/examination-of-single-nucleotide-polymorphisms-in-acetylcholine-recept-article-a4862 Examination of Single Nucleotide Polymorphisms in Acetylcholine Receptors in Chronic Fatigue Syndrome Patients], ''Immunology and Immunogenetics Insights'', 2015:7 7-20. (small study - 115 people with ME/CFS) *May 2015 - [https://journals.sagepub.com/doi/full/10.4137/III.S25147 Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients]<ref>{{Cite journal | last = Marshall-Gradisnik | first = Sonya M. | authorlink = Sonya Marshall-Gradisnik | last2 = Smith | first2 = Peter | authorlink2 = Peter Smith | last3 = Brenu | first3 = Ekua W. | authorlink3 = Ekua Brenu | last4 = Nilius | first4 = Bernd | authorlink4 = Bernd Nilius | last5 = Ramos | first5 = Sandra B. | authorlink5 = Sandra Ramos | last6 = Staines | first6 = Donald R. | date = 2015-01-01 | title = Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients|url=https://doi.org/10.4137/III.S25147|journal=[[Immunology and Immunogenetics Insights]]|language=en|volume=7|issue=|pages=III.S25147|doi=10.4137/III.S25147|issn=1178-6345|quote=|via=}}</ref> (small study - 115 people with ME/CFS) *Apr 2014 - [http://www98.griffith.edu.au/dspace/bitstream/handle/10072/61961/94447_1.pdf?sequence=1 A comparison of health status in patients meeting alternative definitions for chronic fatigue syndrome/myalgic encephalomyelitis], ''Health and Quality of Life Outcomes'', 2014 12:64 **Results: Patients fulfilling the ICC definition reported significantly lower scores (p < 0.05) for physical functioning, physical role, bodily pain, and social functioning than those that only fulfilled the 1994 CDC definition. ICC patients reported significantly greater (p < 0.05) disability across all domains of the WHO DAS 2.0.
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