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National Centre for Neuroimmunology and Emerging Diseases
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The '''National Centre for Neuroimmunology and Emerging Disease''' (NCNED) is an [[Australia|Australian]] research group led by Professors [[Sonya Marshall-Gradisnik]] and [[Donald Staines]].<ref name=":1">{{Cite web|url=https://www.griffith.edu.au/menzies-health-institute-queensland/about-menzieshiq/Infectious-Diseases-and-Immunology/neuroimmunology-and-emerging-diseases | title = National Centre for Neuroimmunology and Emerging Diseases | website = griffith.edu.au|language=en|access-date=2019-10-21}}</ref> The NCNED is a part of [[Menzies Health Institute Queensland]] at [[Griffith University]] in south-east Queensland, [[Australia]].<ref name=":0">{{Cite web|url=https://app.secure.griffith.edu.au/news/2016/12/01/4m-grant-to-aid-chronic-fatigue-syndrome-diagnosis/ | title = $4m grant to aid Chronic Fatigue Syndrome diagnosis | last = Durack | first = Louise | authorlink= | date = December 1, 2016 | website = Griffith News|language=en-EN|archive-url=|archive-date=|url-status=|access-date=2019-04-13}}</ref> ==Members== In addition to co-directors Professors Marshall-Gradisnik and Staines, full members of the NCNED are:<ref name=":1" /> * Dr [[Leighton Barnden]] * Dr [[Hélène Cabanas]] * Dr [[Alfred Lam]] * Dr [[Donald Stewart]] ==Potential biomarker== In February 2016 the research team led by Profs. Staines and Marshall-Gradisnik announced it had created a diagnostic test for the disease using [[CD8]] T cells.<ref name="BioABC">[http://www.abc.net.au/pm/content/2016/s4415928.htm Australian scientists make breakthrough in Chronic Fatigue Syndrome testing], ''ABC News (Australia)'', 29 February 2016</ref><ref>[http://www.meaction.net/2016/02/29/news-report-breakthrough-on-diagnostic-blood-test/ Griffith Uni claims breakthrough on diagnostic test], #MEAction, February 29, 2016</ref><ref name="BioGRI">[https://app.secure.griffith.edu.au/news/2016/03/01/screening-test-for-chronic-fatigue-syndrome-on-its-way/?src=hp Screening test for Chronic Fatigue Syndrome on its way], ''Griffith University'', 1 March 2016</ref><ref name="BioHin">[http://www.hindawi.com/journals/jir/2016/9064529/abs/ A Preliminary Comparative Assessment of the Role of CD8+ T Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis’.], Journal of Immunology Research, Volume 2016 (2016), Article ID 9064529, 8 pages</ref><ref>[http://www.cfstreatmentguide.com/blog/new-screening-test-for-mecfs-announced-by-griffith-university New Screening Test for ME/CFS Announced by Griffith University], ''CFS Treatment Guide'', 5 Mar 2016</ref><ref>[http://www.abc.net.au/news/2016-03-10/chronic-fatigue-syndrome-new-diagnostic-tool/7236182 Chronic fatigue syndrome: new diagnostic tool to speed up treatment and reduce stigma]</ref><ref>[http://www.sciencealert.com/a-screening-test-for-chronic-fatigue-syndrome-is-ready-for-the-public A screening test for chronic fatigue syndrome is ready for the public]</ref> The researchers have submitted patent claims in relation to their discovery.<ref name="BioPa1">[http://pericles.ipaustralia.gov.au/ols/auspat/applicationDetails.do?applicationNo=2015904991 Patent AusPat 2015904991], ''IP Australia'', 2 December 2015</ref><ref name="BioPa2">[http://pericles.ipaustralia.gov.au/ols/auspat/applicationDetails.do?applicationNo=2015901567 Patent AusPat 2015901567], ''IP Australia'', 1 June 2015</ref><ref>[https://www.google.co.uk/patents/WO2016023077A1?cl=en&dq=sonya+marshall-gradisnik Biological markers - WO 2016023077 A1]</ref> Professor Marshall-Gradisnik clarified: "In response to a number of inquiries of this nature we are pleased to advise that we have both published papers, papers in press, and additional data not for publication, which constitutes commercial-in-confidence".<ref name="BioLt1">[https://www.griffith.edu.au/health/national-centre-neuroimmunology-emerging-diseases Statement from NCNED], ''Griffith University'', 1 March 2016</ref><ref name="BioLt2">[https://twitter.com/firestormmer/status/704506838985916417 Letter from Sonya Marshall-Gradisnik], ''Twitter'', 1 March 2016</ref> ==Notable studies== *May 2019, Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients<ref>{{Cite journal | last = Cabanas | first = H. | authorlink = Hélène Cabanas | last2 = Muraki | first2 = K. | authorlink2 = Katsuhiko Muraki | last3 = Balinas | first3 = C. | authorlink3 = Cassandra Balinas | last4 = Eaton-Fitch | first4 = N. | authorlink4 = Natalie Eaton-Fitch | last5 = Staines | first5 = D. | authorlink5 = Donald Staines | last6 = Marshall-Gradisnik | first6 = S. | authorlink6 = Sonya Marshall-Gradisnik | date = 2019-04-23 | title = Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480905/|journal=[[Molecular Medicine]]|volume=25|issue=|pages=|doi=10.1186/s10020-019-0083-4|issn=1076-1551|pmc=6480905|pmid=31014226|quote=|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480905/ (Full text)] *Aug 2018, Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients<ref name="Cabanas2018">{{Cite journal | last = Cabanas | first = Hélène | authorlink = Hélène Cabanas | last2 = Muraki | first2 = Katsuhiko | authorlink2 = Katsuhiko Muraki | last3 = Eaton | first3 = Natalie | author-link3 = Natalie Eaton-Fitch | last4 = Balinas | first4 = Cassandra | authorlink4 = Cassandra Balinas | last5 = Staines | first5 = Donald | authorlink5 = Donald Staines | last6 = Marshall-Gradisnik | first6 = Sonya | authorlink6 = Sonya Marshall-Gradisnik | date = 2018-08-14 | title = Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092868/|journal=[[Molecular Medicine]]|volume=24|issue=|pages=|doi=10.1186/s10020-018-0046-1|issn=1076-1551|pmc=6092868|pmid=30134818|quote=|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092868/#__ffn_sectitle (Full text)] *May 2016, [https://biolres.biomedcentral.com/articles/10.1186/s40659-016-0087-2 Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients]<ref name="TRPM3-2016">{{Cite journal | last = Nguyen | first = T. | authorlink = Thao Nguyen | last2 = Staines | first2 = D. | authorlink2 = Donald Staines | last3 = Nilius | first3 = B. | authorlink3 = B Nilius | last4 = Smith | first4 = P. | authorlink4 = Peter Smith | last5 = Marshall-Gradisnik | first5 = S. | authorlink5 = Sonya Marshall-Gradisnik | date = 2016-05-31 | title = Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients|url=https://doi.org/10.1186/s40659-016-0087-2|journal=[[Biological Research (journal)|Biological Research]]|volume=49|issue=1|pages=27|doi=10.1186/s40659-016-0087-2|issn=0717-6287|pmc=4888729|pmid=27245705|quote=|via=}}</ref> (Full text) *Apr 2016, [http://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0859-z ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56dimCD16+ and CD56brightCD16dim/− natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients]<ref name="Huth2016">{{Cite journal | last = Huth | first = Teilah Kathryn | authorlink = Teilah Huth | last2 = Staines | first2 = Donald | authorlink2 = Donald Staines | last3 = Marshall-Gradisnik | first3 = Sonya | authorlink3 = Sonya Marshall-Gradisnik | authorlink4 = | authorlink5 = | date = 2016-04-21 | title = ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56dimCD16+ and CD56brightCD16dim/− natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients|url=https://doi.org/10.1186/s12967-016-0859-z|journal=[[Journal of Translational Medicine]]|volume=14|issue=1 | pages = 97|doi=10.1186/s12967-016-0859-z|issn=1479-5876|pmc=4839077|pmid=27098723|quote=|via=}}</ref> (Full text) *Jan 2016, [https://journals.sagepub.com/doi/full/10.4137/III.S37042 Genotype Frequencies of Transient Receptor Potential Melastatin M3 Ion Channels and Acetylcholine Muscarinic M3 Receptor Gene Polymorphisms in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients Genotype Frequencies of Transient Receptor Potential Melastatin M3 Ion Channels and Acetylcholine Muscarinic M3 Receptor Gene Polymorphisms in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients]<ref name="Genotype-2016">{{Cite journal | last = Marshall-Gradisnik | first = S.M. | authorlink = Sonya Marshall-Gradisnik | last2 = Chacko | first2 = A. | authorlink2 = A Chacko | last3 = Johnston | first3 = S. | authorlink3 = Samantha Johnston | last4 = Smith | first4 = P. | authorlink4 = Peter Smith | last5 = Nilius | first5 = B. | authorlink5 = B Nilius | last6 = Staines | first6 = D.R. | authorlink6 = Donald Staines | date = 2016-01-01 | title = Genotype Frequencies of Transient Receptor Potential Melastatin M3 Ion Channels and Acetylcholine Muscarinic M3 Receptor Gene Polymorphisms in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients|url=https://doi.org/10.4137/III.S37042|journal=Immunology and Immunogenetics Insights|language=en|volume=8|issue=|pages=III.S37042|doi=10.4137/III.S37042|issn=1178-6345|quote=|via=}}</ref> [https://journals.sagepub.com/doi/full/10.4137/III.S37042 (Full text)] *Dec 2015, [http://www.hindawi.com/journals/jir/2016/9064529/abs/ A Preliminary Comparative Assessment of the Role of CD8+ T Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis]<ref name="CD8+2015">{{Cite web|url=https://www.hindawi.com/journals/jir/2016/9064529/abs/ | title = A Preliminary Comparative Assessment of the Role of CD8 | last = Marshall-Gradisnik | first = Sonya | authorlink=Sonya Marshall-Gradisnik | last2 = Staines | first2 = Don | authorlink2 = Donald Staines | date = 2016 | website = [[Journal of Immunology Research]]|language=en|archive-url=|archive-date=|url-status=|access-date=2019-05-10 | last3 = Ramos | first3 = Sandra | authorlink3 = Sandra Ramos | last4 = Johnston | first4 = Samantha | authorlink4 = Samantha Johnston | last5 = Nguyen | first5 = Thao | authorlink5 = Thao Nguyen | last6 = Broadley | first6 = Simon | authorlink6 = Simon Broadley | last7 = Brenu | first7 = Ekua W. | authorlink7 = Ekua Brenu}}</ref> (Full text) *Dec 2015, [http://onlinelibrary.wiley.com/doi/10.1111/sji.12388/abstract Pilot Study of Natural Killer Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis]<ref name="NKcells-2015">{{Cite journal | last = Huth | first = T.K. | authorlink = Teilah Huth | last2 = Brenu | first2 = E.W. | authorlink2 = Ekua Brenu | last3 = Ramos | first3 = S. | authorlink3 = Sandra Ramos | last4 = Nguyen | first4 = T. | authorlink4 = Thao Nguyen | last5 = Broadley | first5 = S. | authorlink5 = Simon Broadley | last6 = Staines | first6 = D. | authorlink6 = Donald Staines | last7 = Marshall‐Gradisnik | first7 = S. | authorlink7 = Sonya Marshall-Gradisnik | date = 2016 | title=Pilot Study of Natural Killer Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/sji.12388|journal=[[Scandinavian Journal of Immunology]]|language=en|volume=83|issue=1 | pages = 44–51|doi=10.1111/sji.12388|issn=1365-3083|quote=|via=}}</ref> (Abstract) *Sep 2015, [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615236/ Serum Immune Proteins in Moderate and Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients], ''Int J Med Sci'', 2015; 12(10): 764–772. *Aug 2015, [http://translational-medicine.biomedcentral.com/articles/10.1186/s12967-015-0653-3 Longitudinal analysis of immune abnormalities in varying severities of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients], ''Journal of Translatqional Medicine'', 201513:299 **Conclusions: [[Severe and very severe ME|Severe CFS/ME patients]] differed from controls and moderate CFS/ME patients over time and expressed significant alterations in iNKT cell phenotypes, CD8+T cell markers, NK cell receptors and γδT cells at 6 months. *May 2015 - [http://bmcimmunol.biomedcentral.com/articles/10.1186/s12865-015-0101-4 Characterisation of cell functions and receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)], ''BMC Immunology'', 2015 16:35 *May 2015 - [http://www.la-press.com/examination-of-single-nucleotide-polymorphisms-in-acetylcholine-recept-article-a4862 Examination of Single Nucleotide Polymorphisms in Acetylcholine Receptors in Chronic Fatigue Syndrome Patients], ''Immunology and Immunogenetics Insights'', 2015:7 7-20. (small study - 115 people with ME/CFS) *May 2015 - [https://journals.sagepub.com/doi/full/10.4137/III.S25147 Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients]<ref>{{Cite journal | last = Marshall-Gradisnik | first = Sonya M. | authorlink = Sonya Marshall-Gradisnik | last2 = Smith | first2 = Peter | authorlink2 = Peter Smith | last3 = Brenu | first3 = Ekua W. | authorlink3 = Ekua Brenu | last4 = Nilius | first4 = Bernd | authorlink4 = Bernd Nilius | last5 = Ramos | first5 = Sandra B. | authorlink5 = Sandra Ramos | last6 = Staines | first6 = Donald R. | date = 2015-01-01 | title = Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients|url=https://doi.org/10.4137/III.S25147|journal=[[Immunology and Immunogenetics Insights]]|language=en|volume=7|issue=|pages=III.S25147|doi=10.4137/III.S25147|issn=1178-6345|quote=|via=}}</ref> (small study - 115 people with ME/CFS) *Apr 2014 - [http://www98.griffith.edu.au/dspace/bitstream/handle/10072/61961/94447_1.pdf?sequence=1 A comparison of health status in patients meeting alternative definitions for chronic fatigue syndrome/myalgic encephalomyelitis], ''Health and Quality of Life Outcomes'', 2014 12:64 **Results: Patients fulfilling the ICC definition reported significantly lower scores (p < 0.05) for physical functioning, physical role, bodily pain, and social functioning than those that only fulfilled the 1994 CDC definition. ICC patients reported significantly greater (p < 0.05) disability across all domains of the WHO DAS 2.0. ==Funding== The NCNED is supported by the Queensland Government and philanthropic donors.<ref>[https://www.griffith.edu.au/health/national-centre-neuroimmunology-emerging-diseases/partnerships NCNED Partnerships]</ref> In 2016, Professors Marshall-Gradisnik and Staines and Dr [[Samantha Johnston]] were awarded $4 million (AUS) from the [[Stafford Fox Medical Research Foundation]] to accelerate the diagnosis of CFS and the discovery of appropriate treatments.<ref name=":0" /> The grant follows on a previous round of funding ($2.5 million) from the same foundation.<ref name=":0" /> ==Online presence== *[https://www.facebook.com/National-Centre-for-Neuroimmunology-and-Emerging-Diseases-NCNED-301252900007181/ Facebook] *[https://twitter.com/Griffith_Health?s=09 Twitter - Griffith Health] *[https://www.griffith.edu.au/health Website - Griffith Health] *[https://www.griffith.edu.au/health/national-centre-neuroimmunology-emerging-diseases Website - NCNED] *[https://www.youtube.com/watch?v=6v-dpeskfp0&list=PL_DDZIYT9YzKnb2pdscfeIx_MmCYpsAmq YouTube - CFS Myths 1, 2, and 3] via Stuart North's playlist of Griffith University's videos. *Institution *Twitter ==Learn more== *Feb 29, 2016, [http://www.abc.net.au/pm/content/2016/s4415928.htm Australian scientists make breakthrough in Chronic Fatigue Syndrome testing], ''ABC News (Australia)'' *Mar 1, 2016, [https://app.secure.griffith.edu.au/news/2016/03/01/screening-test-for-chronic-fatigue-syndrome-on-its-way/?src=hp Screening test for Chronic Fatigue Syndrome on its way], ''Griffith University'' ==See also== *Professor [[Sonya Marshall-Gradisnik]] *Professor [[Donald Staines]] *Dr. [[Peter Smith]] *Dr. [[Richard Kwiatek]] *Dr. [[Hélène Cabanas]] *[[TRPM3]] *[[Diagnostic biomarker]] ==References== {{reflist}} [[Category:Research initiatives]] [[Category:Australian research initiatives]] [[Category:Tests]]
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