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Myasthenia gravis
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==Acetylcholine== Autoantibodies to [[acetylcholine]] receptors, alpha subunit have been found in patients with myasthenia gravis. These cross react with [[herpesvirus]] glycoprotein D. <ref>{{Cite book |url=https://books.google.com/books?id=5trQOK8hcZUC&pg=PA7&lpg=PA7&dq=coxsackie+b+acetylcholine&source=bl&ots=zhup8ZXq68&sig=CxDwQCHO8-OMBYkcp4EayjnDKnw&hl=en&sa=X&ved=0ahUKEwjflpmqg9fOAhWBeSYKHSR4Dh0Q6AEIMTAD#v=onepage&q=coxsackie%20b%20acetylcholine&f=false | title = Immune-mediated Disorders of the Central Nervous System in Children | last = Angelini | first = Lucia | last2 = Bardare | first2 = Maria | last3 = Martini | first3 = Alberto | last4 = Mariani | first4 = Fondazione Pierfranco e Luisa | date = 2002|publisher=John Libbey Eurotext|isbn=9780861966318|editor-link=|location= | page = 7|language=en|chapter=|quote=|editor-last2 = |editor-link2 = }}</ref> Antibodies to acetylcholine receptor and [[Herpes simplex virus#HSV-1|HSV-1]] antigens crossreact.<ref>{{Cite journal | last = Gebhardt | first = B.M. | date = 2000-06-26 | title = Evidence for antigenic cross-reactivity between herpesvirus and the acetylcholine receptor |url =https://www.ncbi.nlm.nih.gov/pubmed/10742556|journal=Journal of Neuroimmunology|volume=105|issue=2|pages=145β153|issn=0165-5728|pmid=10742556}}</ref> [[B cell]]s from myasthenia gravis patient stimulated ''in vitro'' by [[Epstein-Barr virus]] produced acetylcholine autoantibodies.<ref>{{Cite journal | last = Brenner | first = T. | authorlink = | last2 = Timore | first2 = Y. | authorlink2 = | last3 = Wirguin | first3 = I. | authorlink3 = | last4 = Abramsky | first4 = O. | authorlink4 = | last5 = Steinitz | first5 = M. | authorlink5 = | date = Oct 1989 | title = In vitro synthesis of antibodies to acetylcholine receptor by Epstein-Barr virus-stimulated B-lymphocytes derived from patients with myasthenia gravis|url=https://www.ncbi.nlm.nih.gov/pubmed/2553772|journal=Journal of Neuroimmunology|volume=24|issue=3|pages=217β222|issn=0165-5728|pmid=2553772|quote=|via=}}</ref> Ongoing EBV infection of the [[thymus]] has been posited as a causative agent for the production of aceytlcholine receptor autoantibodies in myasthenia gravis.<ref>{{Cite journal | last = Minarovits | first = Janos | last2 = Kaminski | first2 = Henry J. | title=Epstein-barr virus: Trigger for autoimmunity?|url=https://www.academia.edu/20258853/Epstein-barr_virus_Trigger_for_autoimmunity|journal=Annals of Neurology|language=en|pages=NAβNA|issn=0364-5134}}</ref><ref>http://journals.lww.com/neurologynow/_layouts/15/oaks.journals.mobile/post.aspx?blogId=2&postId=10</ref>
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