Muscle

In ME and CFS

Several of the key symptoms observed by Melvin Ramsay and a part of his Ramsay_definition involved muscle including muscle fatigability along with muscle pain and clumsiness (ataxia). Patients also complain of muscle fasciculations.

Numerous abnormalities have been found in the skeletal muscle of Myalgic Encephalomyelitis patients including:

• mitochondrial abnormalities found via muscle biopsy including: mitochondrial degeneration , deletions of mitochondrial DNA , the reduction of mitochondrial activity
• Increased urinary creatine excretion during relapses
• Increased creatine kinase (postviral fatigue syndrome)
• Persistence of enteroviruses in muscle tissue

See also

• Muscle biopsy

mitochondria Important parts of the biological cell, with each mitochondrion encased within a mitochondrial membrane. Mitochondria are best known for their role in energy production, earning them the nickname "the powerhouse of the cell". Mitochondria also participate in the detection of threats and the response to these threats. One of the responses to threats orchestrated by mitochondria is apoptosis, a cell suicide program used by cells when the threat can not be eliminated.