Muscle: Difference between revisions

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==In ME and CFS==
==In ME and CFS==


Several of the key symptoms observed by [[Melvin Ramsay]] and a part of his [[diagnostic criteria|Ramsay_definition]] involved '''muscle''' including [[muscle fatigability]] along with muscle [[pain]] and clumsiness ([[ataxia]]). Patients also complain of [[muscle fasciculations]].
Several of the key symptoms observed by [[Melvin Ramsay]] and a part of his [[Ramsay definition]] involved '''muscle''' including [[muscle fatigability]] along with muscle [[pain]] and clumsiness ([[ataxia]]). Patients also complain of [[muscle fasciculations]].


Numerous abnormalities have been found in the skeletal muscle of [[Myalgic Encephalomyelitis]] patients including:
Numerous abnormalities have been found in the [[skeletal muscle]] of [[Myalgic Encephalomyelitis]] patients including:
*[[mitochondria]]l abnormalities found via [[muscle biopsy]] including: mitochondrial degeneration <ref name="Behan1991" />, deletions of mitochondrial DNA <ref name="Vecchiet1996" /><ref name="ZhangC1995" />, the reduction of mitochondrial activity <ref name="Vecchiet1996" />
 
*[[Mitochondrion|mitochondria]]l abnormalities found via [[muscle biopsy]] including: mitochondrial degeneration<ref>{{Cite journal | last = Behan | first = W. M.H. | last2 = More | first2 = I.A.R. | last3 = Behan | first3 = P.O. |  date = Dec 1991 | title = Mitochondrial abnormalities in the postviral fatigue syndrome|url=https://link.springer.com/article/10.1007/BF00294431|journal=Acta Neuropathologica|language=en|volume=83|issue=1 | pages = 61–65|doi=10.1007/bf00294431|issn=0001-6322|via= | authorlink3 = Peter Behan}}</ref>, deletions of mitochondrial DNA <ref name=":0">{{Cite journal | date = 1996-04-19 | title = Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome|url=https://www.sciencedirect.com/science/article/abs/pii/0304394096125593|journal=Neuroscience Letters|language=en|volume=208|issue=2|pages=117–120|doi=10.1016/0304-3940(96)12559-3|issn=0304-3940}}</ref><ref name=":1">{{Cite journal | last = Zhang | first = C. | last2 = Baumer | first2 = A. | last3 = Mackay | first3 = I.R. | last4 = Linnane | first4 = A.W. | last5 = Nagley | first5 = P. | date = Apr 1995 | title = Unusual pattern of mitochondrial DNA deletions in skeletal muscle of an adult human with chronic fatigue syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/7633428|journal=Human Molecular Genetics|volume=4|issue=4 | pages = 751–754|issn=0964-6906|pmid=7633428}}</ref>, the reduction of mitochondrial activity<ref name=":0" />
*Increased urinary [[creatine]] excretion during relapses<ref>{{Cite journal | last = Albrecht | first = Robert | date = March 21, 1964 | title = Epidemic Neuromyasthenia Outbreak in a Convent in New York State|url=https://www.ncbi.nlm.nih.gov/pubmed/14100144|journal=Journal of the American Medical Association|volume=187 | pages = 904-907|via=}}</ref>
*Increased [[creatine kinase]] ([[postviral fatigue syndrome]])
*Increased [[creatine kinase]] ([[postviral fatigue syndrome]])
*Persistence of [[enterovirus]]es in muscle tissue<ref name="Lindh1996"/><ref name="McGarry1994"/><ref name="Cunningham, 1990"/><ref name="Dowsett1990"/><ref name="Archard1988"/>
*Persistence of [[enterovirus]]es in muscle tissue<ref>{{Cite journal | last = Gow | first = J.W. | last2 = Behan | first2 = W. M.H. | last3 = Simpson | first3 = K. | last4 = McGarry | first4 = F. | last5 = Keir | first5 = S. | last6 = Behan | first6 = P.O. |  date = 1994-01-01 | title = Studies on Enterovirus in Patients with Chronic Fatigue Syndrome|url=https://academic.oup.com/cid/article-abstract/18/Supplement_1/S126/316946|journal=Clinical Infectious Diseases|language=en|volume=18|issue=Supplement_1|pages=S126–S129|doi=10.1093/clinids/18.Supplement_1.S126|issn=1537-6591|via= | authorlink6 = Peter Behan}}</ref><ref>{{Cite journal | last = Cunningham | first = Louise | last2 = Bowles | first2 = N.E. | last3 = Lane | first3 = R. J.M. | last4 = Dubowitz | first4 = V. | last5 = Archard | first5 = L.C. | date = 1990 | title = Persistence of enteroviral RNA in chronic fatigue syndrome is associated with the abnormal production of equal amounts of positive and negative strands of enteroviral RNA|url=http://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-71-6-1399|journal=Journal of General Virology|volume=71|issue=6|pages=1399–1402|doi=10.1099/0022-1317-71-6-1399}}</ref><ref>{{Cite journal | last = Archard | first = LC | last2 = Bowles | first2 = N E | last3 = Behan | first3 = P O | last4 = Bell | first4 = EJ | last5 = Doyle | first5 = D | date = 1988-06-01 | title = Postviral Fatigue Syndrome: Persistence of Enterovirus RNA in Muscle and Elevated Creatine Kinase, Postviral Fatigue Syndrome: Persistence of Enterovirus RNA in Muscle and Elevated Creatine Kinase|url=https://doi.org/10.1177/014107688808100608|journal=Journal of the Royal Society of Medicine|language=en|volume=81|issue=6|pages=326–329|doi=10.1177/014107688808100608|issn=0141-0768|pmc=|pmid=3404526|via= | authorlink3 = Peter Behan}}</ref><ref>{{Cite journal | last = Gow | first = J.W. | last2 = Behan | first2 = W.M. | last3 = Clements | first3 = G.B. | last4 = Woodall | first4 = C. | last5 = Riding | first5 = M. | last6 = Behan | first6 = P.O. |  date = 1991-03-23 | title = Enteroviral RNA sequences detected by polymerase chain reaction in muscle of patients with postviral fatigue syndrome.|url=https://www.bmj.com/content/302/6778/692|journal=BMJ|language=en|volume=302|issue=6778 | pages = 692–696|doi=10.1136/bmj.302.6778.692|issn=0959-8138|pmid=1850635|via= | authorlink6 = Peter Behan}}</ref>
 
== Studies ==
* 1991, Mitochondrial abnormalities in the postviral fatigue syndrome<ref name=":0" /> - [https://link.springer.com/article/10.1007/BF00294431 (Abstract)]
* 1995, Unusual pattern of mitochondrial DNA deletion in skeletal muscle of an adult human with chronic fatigue syndrome<ref name=":1" /> - [[pubmed:7633428|(Abstract)]]
* 1996, Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome<ref name=":0" /> - [https://www.sciencedirect.com/science/article/abs/pii/0304394096125593 (Abstract)]
* 2020, Altered muscle membrane potential and redox status differentiates two subgroups of patients with chronic fatigue syndrome<ref>{{Cite journal | last= Jammes | first = Yves | authorlink = | last2 = Adjriou | first2 = Nabil | authorlink2 = | last3 = Kipson | first3 = Nathalie | authorlink3 = | last4 = Criado | first4 = Christine | authorlink4 = | last5 = Charpin | first5 = Caroline | authorlink5 = | last6 = Rebaudet | first6 = Stanislas | authorlink6 = | last7 = Stavris | first7 = Chloé | last8 = Guieu | first8 = Régis | last9 = Fenouillet | first9 = Emmanuel | date = Dec 2020 | title = Altered muscle membrane potential and redox status differentiates two subgroups of patients with chronic fatigue syndrome|url=https://link.springer.com/content/pdf/10.1186/s12967-020-02341-9.pdf | journal=Journal of Translational Medicine|language=en|volume=18|issue=1|pages=173|doi=10.1186/s12967-020-02341-9|issn=1479-5876|pmc =  7168976|pmid=32306967|access-date=|quote=|via=}}</ref> - [https://link.springer.com/content/pdf/10.1186/s12967-020-02341-9.pdf (Full text)]
* 2020, Skeletal Muscle Weakness Often Occurs in Patients with Myalgic Encephalomyelitis / Chronic Fatigue Syndrome ME/CFS<ref>{{Cite journal | last= Jammes | first = Y. | authorlink = | last2 = Retornaz | first2 = F. | authorlink2 =  | date = 2020 | title=Skeletal Muscle Weakness Often Occurs in Patients with Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS)|url=https://www.scientificarchives.com/article/skeletal-muscle-weakness-often-occurs-in-patients-with-myalgic-encephalomyelitis--chronic-fatigue-syndrome-mecfs|journal=J Exp Neurol|volume=1|issue=2|pages=35-39|doi=|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.scientificarchives.com/admin/assets/articles/pdf/skeletal-muscle-weakness-often-occurs-in-patients-with-myalgic-encephalomyelitis--chronic-fatigue-syndrome-mecfs-20200529040501.pdf (Full text)]


==See also==
==See also==
*[[Electromyography]]
*[[Muscle biopsy]]
*[[Muscle fasciculations]]
*[[Muscle fatigability]]
*[[Myalgia]]
*[[Paresis]]
*[[Skeletal muscle]]


==Learn more==
==Learn more==


==References==
==References==
{{reflist}}
[[Category:Body systems]]
[[Category:Anatomy]]

Latest revision as of 16:58, April 3, 2023

In ME and CFS[edit | edit source]

Several of the key symptoms observed by Melvin Ramsay and a part of his Ramsay definition involved muscle including muscle fatigability along with muscle pain and clumsiness (ataxia). Patients also complain of muscle fasciculations.

Numerous abnormalities have been found in the skeletal muscle of Myalgic Encephalomyelitis patients including:

Studies[edit | edit source]

  • 1991, Mitochondrial abnormalities in the postviral fatigue syndrome[2] - (Abstract)
  • 1995, Unusual pattern of mitochondrial DNA deletion in skeletal muscle of an adult human with chronic fatigue syndrome[3] - (Abstract)
  • 1996, Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome[2] - (Abstract)
  • 2020, Altered muscle membrane potential and redox status differentiates two subgroups of patients with chronic fatigue syndrome[9] - (Full text)
  • 2020, Skeletal Muscle Weakness Often Occurs in Patients with Myalgic Encephalomyelitis / Chronic Fatigue Syndrome ME/CFS[10] - (Full text)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. Behan, W. M.H.; More, I.A.R.; Behan, P.O. (December 1991). "Mitochondrial abnormalities in the postviral fatigue syndrome". Acta Neuropathologica. 83 (1): 61–65. doi:10.1007/bf00294431. ISSN 0001-6322.
  2. 2.0 2.1 2.2 2.3 "Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome". Neuroscience Letters. 208 (2): 117–120. April 19, 1996. doi:10.1016/0304-3940(96)12559-3. ISSN 0304-3940.
  3. 3.0 3.1 Zhang, C.; Baumer, A.; Mackay, I.R.; Linnane, A.W.; Nagley, P. (April 1995). "Unusual pattern of mitochondrial DNA deletions in skeletal muscle of an adult human with chronic fatigue syndrome". Human Molecular Genetics. 4 (4): 751–754. ISSN 0964-6906. PMID 7633428.
  4. Albrecht, Robert (March 21, 1964). "Epidemic Neuromyasthenia Outbreak in a Convent in New York State". Journal of the American Medical Association. 187: 904–907.
  5. Gow, J.W.; Behan, W. M.H.; Simpson, K.; McGarry, F.; Keir, S.; Behan, P.O. (January 1, 1994). "Studies on Enterovirus in Patients with Chronic Fatigue Syndrome". Clinical Infectious Diseases. 18 (Supplement_1): S126–S129. doi:10.1093/clinids/18.Supplement_1.S126. ISSN 1537-6591.
  6. Cunningham, Louise; Bowles, N.E.; Lane, R. J.M.; Dubowitz, V.; Archard, L.C. (1990). "Persistence of enteroviral RNA in chronic fatigue syndrome is associated with the abnormal production of equal amounts of positive and negative strands of enteroviral RNA". Journal of General Virology. 71 (6): 1399–1402. doi:10.1099/0022-1317-71-6-1399.
  7. Archard, LC; Bowles, N E; Behan, P O; Bell, EJ; Doyle, D (June 1, 1988). "Postviral Fatigue Syndrome: Persistence of Enterovirus RNA in Muscle and Elevated Creatine Kinase, Postviral Fatigue Syndrome: Persistence of Enterovirus RNA in Muscle and Elevated Creatine Kinase". Journal of the Royal Society of Medicine. 81 (6): 326–329. doi:10.1177/014107688808100608. ISSN 0141-0768. PMID 3404526.
  8. Gow, J.W.; Behan, W.M.; Clements, G.B.; Woodall, C.; Riding, M.; Behan, P.O. (March 23, 1991). "Enteroviral RNA sequences detected by polymerase chain reaction in muscle of patients with postviral fatigue syndrome". BMJ. 302 (6778): 692–696. doi:10.1136/bmj.302.6778.692. ISSN 0959-8138. PMID 1850635.
  9. Jammes, Yves; Adjriou, Nabil; Kipson, Nathalie; Criado, Christine; Charpin, Caroline; Rebaudet, Stanislas; Stavris, Chloé; Guieu, Régis; Fenouillet, Emmanuel (December 2020). "Altered muscle membrane potential and redox status differentiates two subgroups of patients with chronic fatigue syndrome" (PDF). Journal of Translational Medicine. 18 (1): 173. doi:10.1186/s12967-020-02341-9. ISSN 1479-5876. PMC 7168976. PMID 32306967.
  10. Jammes, Y.; Retornaz, F. (2020). "Skeletal Muscle Weakness Often Occurs in Patients with Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS)". J Exp Neurol. 1 (2): 35–39.