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Metabolic features of chronic fatigue syndrome
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== Analysis of ''Metabolic features of chronic fatigue syndrome'' == *[[MEAction]] - [http://www.meaction.net/2016/08/30/naviauxs-metabolism-paper-is-about-as-big-as-you-think/ Naviaux’s metabolism paper is about as big as you think]<ref name=":0" /> :<blockquote>For those who are wondering at the results and their implications, Naviaux’s study in a nutshell states that the cells of [[myalgic encephalomyelitis|ME]] patients are in a sort of protective hibernation, limiting their consumption of resources and engaging in a hypometabolic state as a response to infection or other stressors. By examining patients’ metabolites in detail, it was found that this degree of protective hibernation correlates directly to clinical severity.</blockquote> :<blockquote>Naviaux also posits that cells in [[ME/CFS]] are cells under enormous stress, for which they create a series of defenses, metaphorically installing a superior lock and alarm system and hiding all the valuables. However, some pathogens know the code to get in, and when the resources are hidden, the host can’t use them, either. Both of these aspects of this mode of cellular defense have profound implications for symptomology.<ref name=":0">{{Cite news | url=http://www.meaction.net/2016/08/30/naviauxs-metabolism-paper-is-about-as-big-as-you-think/ | title = Naviaux's metabolism paper is about as big as you think - #MEAction | last = Seltzer | first = Jaime | date = 2016-08-30|work=#MEAction|access-date=2018-08-19|archive-url=|archive-date=|url-status=|language=en-US}}</ref></blockquote> *[[Health Rising]] - [http://www.healthrising.org/blog/2016/09/01/metabolomics-naviaux-chronic-fatigue-syndrome-core-problem/ The Core Problem in Chronic Fatigue Syndrome Identified? Naviaux’s Metabolomics Study Breaks Fresh Ground]<ref name=":1" /> :<blockquote>Naviaux believes the mitochondria are able to sense every kind of danger – from pathogens to pH changes to toxic elements from pesticides, heavy metals, etc. to inflammation. They sense trouble in the form of an infection when they detect a drop in voltage caused by the diversion of electrons (NADH / NADPH) to make viral components or respond to a broad variety of toxins.</blockquote> :<blockquote>In the cell danger response (CDR) the mitochondria respond instantaneously to that loss by decreasing their oxygen consumption – thus thwarting pathogens from using the building blocks of the cell to replicate. Because the oxygen is no longer being used, it builds up in the cells causing a oxidatively charged environment which interrupts viral synthesis. The CDR also stiffens the membrane of the cell to stop pathogens from exiting it and warns other cells of the danger and emits ATP in order to warn other cells to get their defenses up.<ref name=":1">{{Cite news | url=http://www.healthrising.org/blog/2016/09/01/metabolomics-naviaux-chronic-fatigue-syndrome-core-problem/ | title = The Core Problem in Chronic Fatigue Syndrome Identified? Naviaux's Metabolomics Study Breaks Fresh Ground - Health Rising | last = Johnson | first =Cort | date = 2016-09-01|work=Health Rising|access-date=2018-08-19|archive-url=|archive-date=|url-status=|language=en-US}}</ref></blockquote>
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