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Metabolic features of chronic fatigue syndrome
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== Thirteen questions answered on ''Metabolic features of chronic fatigue syndrome'' == SUMMARY: Dr. Robert Naviaux answers questions about his findings. Original Q & A: 1-6 <ref>{{Cite web|url=http://naviauxlab.ucsd.edu/wp-content/uploads/2016/08/Metabolomics-QA-for-CFS.pdf?utm_content=buffera881a | title = Metabolic Features of Chronic Fatigue Syndrome | last = | first = | date = Aug 31, 2016 | website = naviauxlab.ucsd.edu|format = PDF | archive-url=|archive-date=|url-status=|access-date=}}</ref> Updated Q & A: 1.1 & 7-12<ref>{{Cite news | url=https://www.omf.ngo/2016/09/09/updated-metabolic-features-of-chronic-fatigue-syndrome-q-a-with-robert-naviaux-md/ | title = UPDATED: Metabolic Features of Chronic Fatigue Syndrome – Q & A with Robert Naviaux, MD {{!}} Open Medicine Foundation | date = 2016-09-09|work=Open Medicine Foundation|access-date=2018-08-19|language=en-US}}</ref> :1. CFS is a real illness with blood chemical signature and is [[Metabolic]], not all in the mind :1.1 Profound personal loss, grief, depression, fear, chronic pain, anxiety, and PTSD all cause chemical changes in the blood that we can measure with metabolomics. The science behind the expanded CFS metabolomics study demands that we ask both CFS subjects and normal controls about psychological trauma to see if this can increase the susceptibility to CFS later in life, and to see how previous trauma might influence current metabolomics. :2. [[Cell danger response hypothesis|Cell danger response]] (CDR) does not switch off and results in a "siege metabolism" :3. People do not hibernate, CFS has a metabolic signature of [[dauer]] :4. Men and women are different in this disease, not related to testosterone or estrogen :5. [[Epigenetics]] and [[DNA Methylation]] pathways relevant to this disease :6. This paper is not related to treatment although Metabolomics will be relevant to any clinical trial of CFS :7. Dr. Naviaux is in agreement with Dr. Davis that chronic use of antibiotics can inhibit mitochondrial function. Therefore long term use of antibiotics with no evidence of an active infection are doing more harm than good. :8. Mitochondria have two main jobs in the cell - energy metabolism and cellular defense and one can be overactive at the expense of the other. Mitochondrial cannot perform both energy and defense (against colds, flu, etc.) at 100% all the time. :9. ''Does the fact that some antibiotics can inhibit mitochondria mean that treatments for [[Lyme disease]] that last too long might actually convert an acute Lyme infection to a chronic post-Lyme syndrome and chronic fatigue syndrome?'' Yes. :10. ''Are there mito-cocktails or supplements that can help until scientists have more definitive treatments?'' There is no simple answer. Flares and jolts to the body systems of CFS patients can occur with mito-cocktails. Start low, and go slow as some doses of B6 and magnesium can cause heart palpitations. :11. By giving antivirals, doctors are not just inhibiting viruses, they are also inhibiting many host cell metabolic functions. Sometimes the inhibition of host cell functions can attenuate ME/CFS symptoms for a time, but in other cases, using potent antiviral drugs inhibits mitochondrial and methylation reactions and can delay a full recovery from ME/CFS. :12. Our studies show that metabolism might be the final common denominator for ME/CFS. It is important to remember that “diet” and “metabolism” are not the same. Diet is what we eat. Metabolism is the performance state of the matrix—the dynamic state of flow in the network that constitutes all the biochemical reactions that our cells use to conduct the business of life.
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