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Mast cell activation syndrome
(section)
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=== Vitamin C === Numerous studies have found [[Vitamin C]] to be inversely correlated with histamine and that the administration of Vitamin C reduces blood [[histamine]] levels.<ref name="clemetson19802">{{Cite journal| issn = 0022-3166| volume = 110 | issue = 4| pages = 662–668| last = Clemetson | first = C.A. | title = Histamine and ascorbic acid in human blood| journal = The Journal of Nutrition | date = April 1980 | pmid = 7365537}}</ref><ref name="johnston1992">{{Cite journal| issn = 0731-5724| volume = 11 | issue = 2| pages = 172–176| last1 = Johnston | first1 = C.S. | last2 = Martin | first2 = L.J. | last3 = Cai | first3 = X.| title = Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis| journal = Journal of the American College of Nutrition | date = April 1992 | pmid = 1578094}}</ref><ref>{{Cite journal | last= Johnston | first = CS | date = December 1996 | title = Vitamin C depletion is associated with alterations in blood histamine and plasma free carnitine in adults|url=https://www.ncbi.nlm.nih.gov/pubmed/8951736|journal=J Am Coll Nutr.|volume=|pages=|via=}}</ref><ref name="Yazdani">{{Cite journal | last = Yazdani|first = Shaik | date = 2016 | title=Relationship Between Vitamin C, Mast Cells, and Inflammation | url =https://www.omicsonline.org/open-access/relationship-between-vitamin-c-mast-cells-and-inflammation-2155-9600-1000456.php?aid=66895|journal=J Nutr Food Sci.|volume=|pages=|via=}}</ref> It does this potentially through several mechanisms: by inhibiting mast cell production; by increasing [[diamine oxidase]] (an [[enzyme]] that breaks down histamine and is chiefly found in the gut); by inhibiting mast cell degranulation (and the release of histamine in the first place),<ref name="Mio1999">{{Cite journal | last = Mio|first = M | date = 1999 | title = Ultraviolet B (UVB) light-induced histamine release from rat peritoneal mast cells and its augmentation by certain phenothiazine compounds|url=https://www.sciencedirect.com/science/article/pii/S0162310998000538|journal=Immunopharmacology|volume=|pages=|via=}}</ref> and by inhibiting [[histidine decarboxylase]] (the enzyme that forms histamine).<ref name="Molderings2016" />
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