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Martin Pall
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==NO/ONOO-cycle== Dr. Pall developed the [[Nitric oxide hypothesis | Nitric Oxide Cycle Theory]], also, called the NO/ONOO-cycle (pronounced "no-oh-no" cycle) which states that this biochemical cycle causes the inflammation present in [[chronic fatigue syndrome]]/[[myalgic encephalomyelitis]] (CFS/ME), [[multiple chemical sensitivity|Multiple Chemical Sensitivity]] (MCS), [[fibromyalgia]] (FM) and possibly a large number of other chronic inflammatory diseases such as heart disease. "Nitric oxide, acting via its product peroxynitrite, a potent oxidant, acts to initiate a biochemical vicious cycle which is the cause of illness," explains Dr. Pall.<ref>{{Cite web|url=https://www.prohealth.com/library/nitric-oxide-cycle-theory-will-it-explain-cfs-fm-and-other-unexplained-illnesses-qa-with-martin-l-pall-phd-24338 | title = Nitric Oxide Cycle Theory: Will It Explain CFS, FM, and Other ‘Unexplained’ Illnesses? - Q&A with Martin L. Pall, PhD | date = 2007-06-22 | website = Prohealth|language=en-US|access-date=2020-03-02}}</ref> He believes that certain over-the-counter supplements, such as [[fish oil]], [[CoQ10]], [[vitamin E]], NAC ([[N-acetylcysteine]]), [[magnesium]], and other [[antioxidants]], can help downregulate the oxidation caused by the nitric oxide cycle.<ref>{{Cite web|url=https://www.prohealth.com/library/antioxidant-suggestions-for-down-regulation-of-the-no-onoo-cycle-from-dr-martin-pall-phd-28465 | title = Antioxidant Suggestions For Down-regulation of the NO/ONOO- Cycle from Dr. Martin Pall, PhD | last = Pall|first = Martin L. | date = 2007-06-12 | website = Prohealth|language=en-US|access-date=2020-03-02}}</ref> He believes [[Vitamin B12]] injections can also be a potent nitric oxide scavenger.<ref name=":0">{{Cite web|url=http://www.investinme.org/IIMEC2.shtml | title = Invest in ME Research - IIMEC2 | website = [[Invest in ME Research]]|access-date=2020-03-02}}</ref>
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