Marked, rapid physical and/or cognitive fatigability in response to exertion

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Marked, rapid physical and/or cognitive fatigability in response to exertion, or rapid fatigability in response to exertion (which may be minimal such as activities of daily living or simple mental tasks) is a compulsory symptom of the International Consensus Criteria for myalgic encephalomyelitis.[1]. The fatigability is not simply sudden but is frequently debilitating, and cause a relapse.[1]

Prevalence[edit | edit source]

The marked, rapid and usually highly debilitating fatigability is one of the compulsory criteria of post-exertional neuroimmune exhaustion (PENE), the hallmark symptom of ME in the International Consensus Criteria. It is also mentioned in many other diagnostic criteria definitions of ME/CFS including the current CDC ME/CFS criteria.[2][1]

Symptom recognition[edit | edit source]

Notable studies[edit | edit source]

Possible causes[edit | edit source]

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