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Marked, rapid physical and/or cognitive fatigability in response to exertion
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{{stub}} '''Marked, rapid physical and/or cognitive fatigability in response to exertion,''' or '''rapid fatigability''' in response to exertion (which may be minimal such as activities of daily living or simple mental tasks) is a compulsory symptom of the [[International Consensus Criteria]] for [[myalgic encephalomyelitis]].<ref name="ICC2011primer"/>. The fatigability is not simply sudden but is frequently debilitating, and cause a [[relapse]].<ref name="ICC2011primer">{{citation | last1 = Carruthers | first1 = BM | authorlink1 = Bruce Carruthers | last2 = van de Sande | first2 = MI | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = KL | authorlink3 = Kenny de Meirleir | last4 = Klimas | first4 = NG | authorlink4 = Nancy Klimas | last5 = Broderick | first5 = G | authorlink5 = Gordon Broderick | last6 = Mitchell | first6 = T | authorlink6 = Terry Mitchell | last7 = Staines | first7 = D | authorlink7 = Donald Staines | last8 = Powles | first8 = ACP | authorlink8 = A C Peter Powles | last9 = Speight | first9 = N | authorlink9 = Nigel Speight | last10 = Vallings | first10 = R | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = L | authorlink11 = Lucinda Bateman | last12 = Bell | first12 = DS | authorlink12 = David Bell | last13 = Carlo-Stella | first13 = N | authorlink13 = Nicoletta Carlo-Stella | last14 = Chia | first14 = J | authorlink14 = John Chia | last15 = Darragh | first15 = A | authorlink15 = Austin Darragh | last16 = Gerken | first16 = A | authorlink16 = Anne Gerken | last17 = Jo | first17 = D | authorlink17 = Daehyun Jo | last18 = Lewis | first18 = DP | authorlink18 = Donald Lewis | last19 = Light | first19 = AR | authorlink19 = Alan Light | last20 = Light | first20 = KC | authorlink20 = Kathleen Light | last21 = Marshall-Gradisnik | first21 = S | authorlink21 = Sonya Marshall-Gradisnik | last22 = McLaren-Howard | first22 = J | authorlink22 = John McLaren-Howard | last23 = Mena | first23 = I | authorlink23 = Ismael Mena | last24 = Miwa | first24 = K | authorlink24 = Kunihisa Miwa | last25 = Murovska | first25 = M | authorlink25= Modra Murovska | last26 = Stevens | first26 = SR | authorlink26 = Staci Stevens | title = Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners | date = 2012| isbn = 978-0-9739335-3-6 | url = http://www.investinme.org/Documents/Guidelines/Myalgic%20Encephalomyelitis%20International%20Consensus%20Primer%20-2012-11-26.pdf}}</ref> ==Prevalence== The marked, rapid and usually highly debilitating fatigability is one of the compulsory criteria of [[post-exertional neuroimmune exhaustion]] (PENE), the hallmark symptom of ME in the [[International Consensus Criteria]]. It is also mentioned in many other diagnostic criteria definitions of [[ME/CFS]] including the current [[Systemic Exertion Intolerance Disease#CDC|CDC ME/CFS criteria]].<ref name="CDC-symptoms">{{Cite web|url = https://www.cdc.gov/me-cfs/symptoms-diagnosis/symptoms.html | title = Symptoms {{!}} Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|website=[[Centers for Disease Control and Prevention]] | date = Jan 27, 2021|access-date = 2021-02-25}}</ref><ref name="ICC2011primer"/> ==Symptom recognition== ==Notable studies== ==Possible causes== ==See also == *[[Post-exertional neuroimmune exhaustion]] *[[Post-exertional malaise]] ==Learn more == ==References == {{Reflist}} [[Category:Signs and symptoms]] [[Category:Neurological signs and symptoms]] [[Category:Post-exertional neuroimmune signs and symptoms]]
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