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Macrophagic myofasciitis
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{{stub}} '''Macrophagic myofasciitis''' or '''MMF''' is a rare condition that causes [[chronic fatigue]] and [[muscle pain]], and may result in patients being diagnosed with [[chronic fatigue syndrome]].<ref name="Rigolet2012">{{Cite journal|last = Gherardi|first = RK | last2 = Authier | first2 = FJ | date = 2012-02-01 | title = Macrophagic myofasciitis: characterization and pathophysiology|url=https://doi.org/10.1177/0961203311429557|journal=Lupus|language=en|volume=21|issue=2|pages=184–189|doi=10.1177/0961203311429557|issn=0961-2033|pmc = 3623725|pmid=22235051}}</ref> It is regarded as a form of [[autoimmune syndrome induced by adjuvants]] (ASIA).<ref name="Rigolet2012" /> ==Signs and symptoms== * Widespread [[myalgia|muscle pain]] *[[Chronic fatigue]] *[[Cognitive dysfunction]] (brain fog) *Weakness at the site of a vaccine *Raised level of creatine kinase *Raised level of [[erythrocyte sedimentation rate]]<ref name="Rigolet2012" /><ref name=> https://books.google.com/books/about/Textbook_of_Pediatric_Rheumatology_E_Boo.html?id=oEemcpeEufoC</ref > ==Diagnosis== A muscle biopsy at the site of the vaccine<ref name="Rigolet2012" /> ==Treatment== ==ME/CFS== Many patients with MMF meet the now disused [[Oxford criteria]] for [[chronic fatigue syndrome]], or the more commonly used [[Fukuda criteria]]. ==Notable articles== *2003, Chronic fatigue syndrome in patients with macrophagic myofasciitis<ref>{{Cite journal | last = Authier | first = François-Jérôme | authorlink = François Jérôme Authier | last2 = Sauvat | first2 = Stéphane | authorlink2 = | last3 = Champey | first3 = Julien | authorlink3 = | last4 = Drogou | first4 = Irène | authorlink4 = | last5 = Coquet | first5 = Michèle | authorlink5 = | last6 = Gherardi | first6 = Romain K. | authorlink6 = | date = 2003 | title=Chronic fatigue syndrome in patients with macrophagic myofasciitis|url=https://onlinelibrary.wiley.com/doi/abs/10.1002/art.10740|journal=Arthritis & Rheumatism|language=en|volume=48|issue=2 | pages = 569–570|doi=10.1002/art.10740|issn=1529-0131|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://onlinelibrary.wiley.com/doi/full/10.1002/art.10740 (Full text)] *2006, Atypical presentation of macrophagic myofasciitis 10 years post vaccination<ref name="Atypical">{{Cite journal|last = Ryan | first = Aisling M. | authorlink = | last2 = Bermingham | first2 = Niamh | authorlink2 = | last3 = Harrington | first3 = Hugh J. | authorlink3 = | last4 = Keohane | first4 = Catherine | authorlink4 = | date = Dec 2006 | title = Atypical presentation of macrophagic myofasciitis 10 years post vaccination | url =https://doi.org/10.1016/j.nmd.2006.07.017|journal=Neuromuscular Disorders|volume=16|issue=12 | pages = 867–869|doi=10.1016/j.nmd.2006.07.017|issn=0960-8966|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://doi.org/10.1016/j.nmd.2006.07.017 (Full text)] *2009, A role for the body burden of aluminium in vaccine-associated macrophagic myofasciitis and chronic fatigue syndrome<ref>{{Cite journal|last = Exley|first = Christopher | last2 = Swarbrick | first2 = Louise | last3 = Gherardi | first3 = Rhomain K. | last4 = Authier | first4 = Francois-Jérôme | date = 2009-02-01 | title = A role for the body burden of aluminium in vaccine-associated macrophagic myofasciitis and chronic fatigue syndrome|url=http://www.sciencedirect.com/science/article/pii/S0306987708004933|journal=Medical Hypotheses|language=en|volume=72|issue=2|pages=135–139|doi=10.1016/j.mehy.2008.09.040|issn=0306-9877}}</ref> - [https://www.sciencedirect.com/science/article/pii/S0306987708004933 (Full text)] *2014, Clinical features in patients with long-lasting macrophagic myofasciitis<ref>{{Cite journal|last = Rigolet | first = Muriel | last2 = Aouizerate | first2 = Jessie | last3 = Couette | first3 = Maryline | last4 = Ragunathan-Thangarajah | first4 = Nilusha | last5 = Aoun-Sebaiti | first5 = Mehdi | last6 = Gherardi | first6 = Romain Kroum | last7 = Cadusseau | first7 = Josette | last8 = Authier | first8 = François Jérôme | date = 2014 | title = Clinical Features in Patients with Long-Lasting Macrophagic Myofasciitis|url=https://www.frontiersin.org/articles/10.3389/fneur.2014.00230/full|journal=Frontiers in Neurology|language=English|volume=5|doi=10.3389/fneur.2014.00230|issn=1664-2295}}</ref> [https://www.frontiersin.org/articles/10.3389/fneur.2014.00230/full - (Full text)] ==See also== *Differential diagnosis *[[Autoimmune syndrome induced by adjuvants]] *[[Idiopathic chronic fatigue]] ==Learn more== * ==References== {{reflist}} [[Category:Diagnoses]] [[Category:Potential comorbidities]] [[Category:Autoimmune diseases and disorders]] [[Category:Neurological diseases and disorders]]
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