Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
List of symptoms in ME CFS/ICC/PENE
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
<noinclude> {{mbox|text=This page is used as a transclusion for other pages only.}} <dd><dt class="mw-body-text" style="margin:0">Post-exertional Neuroimmune Exhaustion</dt> (PENE) is a '''compulsory''' [[neuroimmune disease|neuroimmune]] symptom in the [[International Consensus Criteria]] diagnostic criteria for [[Myalgic Encephalomyelitis]]. <dl class="mw-body-text">PENE is also known as [[Post-exertional malaise|Post-exertional Malaise]] (PEM).</dl><dd> </noinclude>This cardinal feature is a [[pathological inability to produce sufficient energy on demand with prominent symptoms primarily in the neuroimmune regions|'''pathological inability to produce sufficient energy on demand''' with '''prominent symptoms primarily in the neuroimmune regions]]'''. Characteristics are: * '''[[Marked, rapid physical and/or cognitive fatigability in response to exertion]]''', which may be minimal such as activities of daily living or simple mental tasks, can be debilitating and cause a [[relapse]]. *'''[[Post-exertional symptom exacerbation]]: ''e.g.'' '''acute [[flu-like symptoms]], [[pain]] and worsening of other symptoms. * '''[[Post-exertional exhaustion: immediate or delayed|Post-exertional exhaustion may occur immediately after activity or be delayed by hours or days]].''' *'''[[Recovery period is prolonged, usually taking 24 hours or longer]].''' A [[relapse]] can last days, weeks or longer. * '''[[lack of stamina|Low threshold of physical and mental fatigability]]''' (lack of stamina) results in a [[Substantial reduction or impairment in the ability to engage in pre-illness levels of occupational, educational, social, or personal activities|substantial reduction in pre-illness activity level]]. <noinclude><ref name="ICP2011primer" /> == Learn more == * [[List of symptoms in ME_CFS|List of symptoms in ME/CFS]] * [[International Consensus Criteria]] ==References == <references> <ref name="ICP2011primer">{{citation | last = Carruthers | first1 = BM | authorlink1 = Bruce Carruthers | last2 = van de Sande | first2 = MI | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = KL | authorlink3 = Kenny de Meirleir | last4 = Klimas | first4 = NG | authorlink4 = Nancy Klimas | last5 = Broderick | first5 = G | authorlink5 = Gordon Broderick | last6 = Mitchell | first6 = T | authorlink6 = Terry Mitchell | last7 = Staines | first7 = D | authorlink7 = Donald Staines | last8 = Powles | first8 = ACP | authorlink8 = A C Peter Powles | last9 = Speight | first9 = N | authorlink9 = Nigel Speight | last10 = Vallings | first10 = R | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = L | authorlink11 = Lucinda Bateman | last12 = Bell | first12 = DS | authorlink12 = David Bell | last13 = Carlo-Stella | first13 = N | authorlink13= Nicoletta Carlo-Stella | last14 = Chia | first14 = J | authorlink14 = John Chia | last15 = Darragh | first15 = A | authorlink15 = Austin Darragh | last16 = Gerken | first16 = A | authorlink16 = Anne Gerken | last17 = Jo | first17 = D | authorlink17 = Daehyun Jo | last18 = Lewis | first18 = DP | authorlink18 = Donald Lewis | last19 = Light | first19 = AR | authorlink19 = Alan Light | last20 = Light | first20 = KC | authorlink20 = Kathleen Light | last21 = Marshall-Gradisnik | first21 = S | authorlink21 = Sonya Marshall-Gradisnik | last22 = McLaren-Howard | first22 = J | authorlink22 = John McLaren-Howard | last23 = Mena | first23 = I | authorlink23 = Ismael Mena | last24 = Miwa | first24 = K | authorlink24 = Kunihisa Miwa | last25 = Murovska | first25 = M | authorlink25= Modra Murovska | last26 = Stevens | first26 = SR | authorlink26 = Staci Stevens | title = Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners | date = 2012 | isbn = 978-0-9739335-3-6 | url = http://www.investinme.org/Documents/Guidelines/Myalgic%20Encephalomyelitis%20International%20Consensus%20Primer%20-2012-11-26.pdf }}</ref> </references> </noinclude> [[Category:Neurological signs and symptoms]]
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Templates used on this page:
Template:Citation
(
edit
)
Template:Mbox
(
edit
)
Module:Arguments
(
edit
)
Module:Citation/CS1
(
edit
)
Module:Citation/CS1/COinS
(
edit
)
Module:Citation/CS1/Configuration
(
edit
)
Module:Citation/CS1/Date validation
(
edit
)
Module:Citation/CS1/Identifiers
(
edit
)
Module:Citation/CS1/Utilities
(
edit
)
Module:Citation/CS1/Whitelist
(
edit
)
Module:Message box
(
edit
)
Module:Message box/configuration
(
edit
)
Module:No globals
(
edit
)
Module:Yesno
(
edit
)
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs