List of herpesvirus infection studies: Difference between revisions
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
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==Epstein-Barr virus studies== | ==Epstein-Barr virus studies== | ||
Epstein-Barr virus (EBV) is found in 95% of the adult population (usually in a latent state), and is the most common cause of [[mononucleosis]]. | Epstein-Barr virus (EBV) is found in 95% of the adult population (usually in a latent state),<ref>{{Cite web|url=https://www.cdc.gov/epstein-barr/about-ebv.html|title=Epstein-barr {{!}} Mononucleosis {{!}} About Virus {{!}} Mono {{!}} CDC|date=2019-01-28|website=www.cdc.gov|language=en-us|access-date=2020-08-19}}</ref> and is the most common cause of [[mononucleosis]]. | ||
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|'''<big><span style="color:#3c3">+</span></big>''' | |'''<big><span style="color:#3c3">+</span></big>''' | ||
|'''Chronic fatigue syndrome after infectious mononucleosis in adolescents''' | |'''Chronic fatigue syndrome after infectious mononucleosis in adolescents''' | ||
Ben Z Katz, Yukiko Shiraishi, Cynthia J Mears, Helen J Binns, Renee Taylor | Ben Z Katz, Yukiko Shiraishi, Cynthia J Mears, Helen J Binns, Renee Taylor <ref>{{Cite journal|last=Katz|first=Ben Z.|last2=Shiraishi|first2=Yukiko|last3=Mears|first3=Cynthia J.|last4=Binns|first4=Helen J.|last5=Taylor|first5=Renee|date=2009-07|title=Chronic fatigue syndrome after infectious mononucleosis in adolescents|url=https://pubmed.ncbi.nlm.nih.gov/19564299/|journal=Pediatrics|volume=124|issue=1|pages=189–193|doi=10.1542/peds.2008-1879|issn=1098-4275|pmc=2756827|pmid=19564299}}</ref> | ||
| 2009 | | 2009 | ||
| This study of 301 adolescents with infectious mononucleosis found that at 6, 12, and 24 months after mononucleosis, 13%, 7%, and 4% of these adolescents respectively met the criteria for ME/CFS. | | This study of 301 adolescents with infectious mononucleosis found that at 6, 12, and 24 months after mononucleosis, 13%, 7%, and 4% of these adolescents respectively met the criteria for ME/CFS. | ||
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|'''<big><span style="color:#3c3">+</span></big>''' | |'''<big><span style="color:#3c3">+</span></big>''' | ||
|'''Antibody to Epstein-Barr virus deoxyuridine triphosphate nucleotidohydrolase and deoxyribonucleotide polymerase in a chronic fatigue syndrome subset''' | |'''Antibody to Epstein-Barr virus deoxyuridine triphosphate nucleotidohydrolase and deoxyribonucleotide polymerase in a chronic fatigue syndrome subset''' | ||
A Martin Lerner, Maria E Ariza, Marshall Williams, Leonard Jason, Safedin Beqaj, James T Fitzgerald, Stanley Lemeshow, Ronald Glaser | A Martin Lerner, Maria E Ariza, Marshall Williams, Leonard Jason, Safedin Beqaj, James T Fitzgerald, Stanley Lemeshow, Ronald Glaser <ref>{{Cite journal|last=Lerner|first=A. Martin|last2=Ariza|first2=Maria E.|last3=Williams|first3=Marshall|last4=Jason|first4=Leonard|last5=Beqaj|first5=Safedin|last6=Fitzgerald|first6=James T.|last7=Lemeshow|first7=Stanley|last8=Glaser|first8=Ronald|date=2012|title=Antibody to Epstein-Barr virus deoxyuridine triphosphate nucleotidohydrolase and deoxyribonucleotide polymerase in a chronic fatigue syndrome subset|url=https://pubmed.ncbi.nlm.nih.gov/23155374/|journal=PloS One|volume=7|issue=11|pages=e47891|doi=10.1371/journal.pone.0047891|issn=1932-6203|pmc=3498272|pmid=23155374}}</ref> | ||
|2012 | |2012 | ||
|This study of 20 ME/CFS patients and 20 healthy controls found 94% of patients were positive for EBV early antigen diffuse, versus 32% of the healthy controls; 44% of patients were positive for EBV dUTPase, versus 0% of the controls; 79% of patients were positive for EBV DNA polymerase, versus 0% of the controls. | |This study of 20 ME/CFS patients and 20 healthy controls found 94% of patients were positive for EBV early antigen diffuse, versus 32% of the healthy controls; 44% of patients were positive for EBV dUTPase, versus 0% of the controls; 79% of patients were positive for EBV DNA polymerase, versus 0% of the controls. | ||
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==HHV-6 studies== | ==HHV-6 studies== | ||
HHV-6 is found in nearly 100% of adults (usually in a latent state). | HHV-6 is found in nearly 100% of adults (usually in a latent state).<ref>{{Cite journal|last=Ansari|first=Asad|last2=Li|first2=Shaobing|last3=Abzug|first3=Mark J.|last4=Weinberg|first4=Adriana|date=2004-8|title=Human Herpesviruses 6 and 7 and Central Nervous System Infection in Children1|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320425/|journal=Emerging Infectious Diseases|volume=10|issue=8|pages=1450–1454|doi=10.3201/eid1008.030788|issn=1080-6040|pmc=3320425|pmid=15496247}}</ref> | ||
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|'''<big><span style="color:#3c3">+</span></big>''' | |'''<big><span style="color:#3c3">+</span></big>''' | ||
|'''Prevalence of human herpesvirus 6 variants A and B in patients with chronic fatigue syndrome''' | |'''Prevalence of human herpesvirus 6 variants A and B in patients with chronic fatigue syndrome''' | ||
S Yalcin, H Kuratsune, K Yamaguchi, T Kitani, K Yamanishi | S Yalcin, H Kuratsune, K Yamaguchi, T Kitani, K Yamanishi <ref>{{Cite journal|last=Yalcin|first=S.|last2=Kuratsune|first2=H.|last3=Yamaguchi|first3=K.|last4=Kitani|first4=T.|last5=Yamanishi|first5=K.|date=1994|title=Prevalence of human herpesvirus 6 variants A and B in patients with chronic fatigue syndrome|url=https://pubmed.ncbi.nlm.nih.gov/7968694/|journal=Microbiology and Immunology|volume=38|issue=7|pages=587–590|doi=10.1111/j.1348-0421.1994.tb01827.x|issn=0385-5600|pmid=7968694}}</ref> | ||
|2000 | |2000 | ||
|This study examined 13 cases of ME/CFS and 13 healthy controls. In the peripheral blood mononuclear cells, HHV-6 DNA was detected in 53% of the patients, but no HHV-6 DNA was detected in the controls. Higher antibody levels to the HHV-6 late antigen were found in patients, and antibodies to HHV-6 early antigen were more prevalent in patients. | |This study examined 13 cases of ME/CFS and 13 healthy controls. In the peripheral blood mononuclear cells, HHV-6 DNA was detected in 53% of the patients, but no HHV-6 DNA was detected in the controls. Higher antibody levels to the HHV-6 late antigen were found in patients, and antibodies to HHV-6 early antigen were more prevalent in patients. | ||
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==Cytomegalovirus studies== | ==Cytomegalovirus studies== | ||
Cytomegalovirus is found in | Cytomegalovirus is found in 58% of adults (usually in a latent state).<ref>{{Cite journal|last=Dollard|first=Sheila C.|last2=Staras|first2=Stephanie A. S.|last3=Amin|first3=Minal M.|last4=Schmid|first4=D. Scott|last5=Cannon|first5=Michael J.|date=2011-11|title=National prevalence estimates for cytomegalovirus IgM and IgG avidity and association between high IgM antibody titer and low IgG avidity|url=https://pubmed.ncbi.nlm.nih.gov/21918114/|journal=Clinical and vaccine immunology: CVI|volume=18|issue=11|pages=1895–1899|doi=10.1128/CVI.05228-11|issn=1556-679X|pmc=3209034|pmid=21918114}}</ref> Cytomegalovirus is a rarer cause of mononucleosis. | ||
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== Varicella zoster virus studies== | == Varicella zoster virus studies== | ||
Varicella zoster virus (VZV) is found in 88% of the adult population (usually in a latent state). It causes chickenpox and shingles. | Varicella zoster virus (VZV) is found in 88% of the adult population (usually in a latent state).<ref>{{Cite journal|last=Fatha|first=Noorul|last2=Ang|first2=Li Wei|last3=Goh|first3=Kee Tai|date=2014-05|title=Changing seroprevalence of varicella zoster virus infection in a tropical city state, Singapore|url=https://pubmed.ncbi.nlm.nih.gov/24269652/|journal=International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases|volume=22|pages=73–77|doi=10.1016/j.ijid.2013.10.003|issn=1878-3511|pmid=24269652}}</ref> It causes chickenpox and shingles. | ||
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== Herpes simplex virus studies== | == Herpes simplex virus studies== | ||
Herpes simplex virus I is found in 54% of adults, and herpes simplex virus II in 16% of adults (usually in a latent state). HSV causes oral mouth sores. | Herpes simplex virus I is found in 54% of adults, and herpes simplex virus II in 16% of adults (usually in a latent state).<ref>{{Cite journal|last=Bradley|first=Heather|last2=Markowitz|first2=Lauri E.|last3=Gibson|first3=Theda|last4=McQuillan|first4=Geraldine M.|date=2014-02-01|title=Seroprevalence of herpes simplex virus types 1 and 2--United States, 1999-2010|url=https://pubmed.ncbi.nlm.nih.gov/24136792/|journal=The Journal of Infectious Diseases|volume=209|issue=3|pages=325–333|doi=10.1093/infdis/jit458|issn=1537-6613|pmid=24136792}}</ref> HSV causes oral mouth sores. | ||
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== HHV-7 studies== | == HHV-7 studies== | ||
HHV-7 is found in more than | HHV-7 is found in more than 95% of the adult population (usually in a latent state).<ref>{{Cite journal|last=Clark|first=D. A.|last2=Freeland|first2=M. L.|last3=Mackie|first3=L. K.|last4=Jarrett|first4=R. F.|last5=Onions|first5=D. E.|date=1993-07|title=Prevalence of antibody to human herpesvirus 7 by age|url=https://pubmed.ncbi.nlm.nih.gov/8390545/|journal=The Journal of Infectious Diseases|volume=168|issue=1|pages=251–252|doi=10.1093/infdis/168.1.251|issn=0022-1899|pmid=8390545}}</ref> | ||
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Revision as of 21:38, August 19, 2020
Herpesvirus family viruses including Epstein-Barr virus, human herpesvirus 6 (HHV-6) and cytomegalovirus are associated with myalgic encephalomyelitis. This article lists herpesvirus studies examining the role and prevalence of herpesviruses in ME/CFS patients. Positive studies (finding herpesvirus more prevalent in ME/CFS patients than healthy controls) are indicated by a + symbol, whereas negative studies (finding no significant difference in prevalence between patients and healthy) are indicated by the − symbol.
Epstein-Barr virus studies[edit | edit source]
Epstein-Barr virus (EBV) is found in 95% of the adult population (usually in a latent state),[1] and is the most common cause of mononucleosis.
| Study Title | Date | Details | |
|---|---|---|---|
| + | Chronic fatigue syndrome after infectious mononucleosis in adolescents
Ben Z Katz, Yukiko Shiraishi, Cynthia J Mears, Helen J Binns, Renee Taylor [2] |
2009 | This study of 301 adolescents with infectious mononucleosis found that at 6, 12, and 24 months after mononucleosis, 13%, 7%, and 4% of these adolescents respectively met the criteria for ME/CFS. |
| + | Antibody to Epstein-Barr virus deoxyuridine triphosphate nucleotidohydrolase and deoxyribonucleotide polymerase in a chronic fatigue syndrome subset
A Martin Lerner, Maria E Ariza, Marshall Williams, Leonard Jason, Safedin Beqaj, James T Fitzgerald, Stanley Lemeshow, Ronald Glaser [3] |
2012 | This study of 20 ME/CFS patients and 20 healthy controls found 94% of patients were positive for EBV early antigen diffuse, versus 32% of the healthy controls; 44% of patients were positive for EBV dUTPase, versus 0% of the controls; 79% of patients were positive for EBV DNA polymerase, versus 0% of the controls. |
| + | XXXX
XXXX |
XXXX | XXXX. |
HHV-6 studies[edit | edit source]
HHV-6 is found in nearly 100% of adults (usually in a latent state).[4]
| Study Title | Date | Details | |
|---|---|---|---|
| + | Prevalence of human herpesvirus 6 variants A and B in patients with chronic fatigue syndrome
S Yalcin, H Kuratsune, K Yamaguchi, T Kitani, K Yamanishi [5] |
2000 | This study examined 13 cases of ME/CFS and 13 healthy controls. In the peripheral blood mononuclear cells, HHV-6 DNA was detected in 53% of the patients, but no HHV-6 DNA was detected in the controls. Higher antibody levels to the HHV-6 late antigen were found in patients, and antibodies to HHV-6 early antigen were more prevalent in patients. |
| + | XXXX
XXXX |
XXXX | XXXX. |
Cytomegalovirus studies[edit | edit source]
Cytomegalovirus is found in 58% of adults (usually in a latent state).[6] Cytomegalovirus is a rarer cause of mononucleosis.
| Study Title | Date | Details | |
|---|---|---|---|
| + | XXXX
XXXX |
XXXX | XXXX. |
Varicella zoster virus studies[edit | edit source]
Varicella zoster virus (VZV) is found in 88% of the adult population (usually in a latent state).[7] It causes chickenpox and shingles.
| Study Title | Date | Details | |
|---|---|---|---|
| + | XXXX
XXXX |
XXXX | XXXX. |
Herpes simplex virus studies[edit | edit source]
Herpes simplex virus I is found in 54% of adults, and herpes simplex virus II in 16% of adults (usually in a latent state).[8] HSV causes oral mouth sores.
| Study Title | Date | Details | |
|---|---|---|---|
| + | XXXX
XXXX |
XXXX | XXXX. |
HHV-7 studies[edit | edit source]
HHV-7 is found in more than 95% of the adult population (usually in a latent state).[9]
| Study Title | Date | Details | |
|---|---|---|---|
| + | XXXX
XXXX |
XXXX | XXXX. |
See also[edit | edit source]
- Epstein-Barr virus
- Human herpesvirus 6
- Cytomegalovirus
- Varicella zoster virus
- Herpes simplex virus
- Human herpesvirus 7
- List of enterovirus infection studies
Learn more[edit | edit source]
References[edit | edit source]
- ↑ "Epstein-barr | Mononucleosis | About Virus | Mono | CDC". www.cdc.gov. January 28, 2019. Retrieved August 19, 2020.
- ↑ Katz, Ben Z.; Shiraishi, Yukiko; Mears, Cynthia J.; Binns, Helen J.; Taylor, Renee (2009-07). "Chronic fatigue syndrome after infectious mononucleosis in adolescents". Pediatrics. 124 (1): 189–193. doi:10.1542/peds.2008-1879. ISSN 1098-4275. PMC 2756827. PMID 19564299. Check date values in:
|date=(help) - ↑ Lerner, A. Martin; Ariza, Maria E.; Williams, Marshall; Jason, Leonard; Beqaj, Safedin; Fitzgerald, James T.; Lemeshow, Stanley; Glaser, Ronald (2012). "Antibody to Epstein-Barr virus deoxyuridine triphosphate nucleotidohydrolase and deoxyribonucleotide polymerase in a chronic fatigue syndrome subset". PloS One. 7 (11): e47891. doi:10.1371/journal.pone.0047891. ISSN 1932-6203. PMC 3498272. PMID 23155374.
- ↑ Ansari, Asad; Li, Shaobing; Abzug, Mark J.; Weinberg, Adriana (2004-8). "Human Herpesviruses 6 and 7 and Central Nervous System Infection in Children1". Emerging Infectious Diseases. 10 (8): 1450–1454. doi:10.3201/eid1008.030788. ISSN 1080-6040. PMC 3320425. PMID 15496247. Check date values in:
|date=(help) - ↑ Yalcin, S.; Kuratsune, H.; Yamaguchi, K.; Kitani, T.; Yamanishi, K. (1994). "Prevalence of human herpesvirus 6 variants A and B in patients with chronic fatigue syndrome". Microbiology and Immunology. 38 (7): 587–590. doi:10.1111/j.1348-0421.1994.tb01827.x. ISSN 0385-5600. PMID 7968694.
- ↑ Dollard, Sheila C.; Staras, Stephanie A. S.; Amin, Minal M.; Schmid, D. Scott; Cannon, Michael J. (2011-11). "National prevalence estimates for cytomegalovirus IgM and IgG avidity and association between high IgM antibody titer and low IgG avidity". Clinical and vaccine immunology: CVI. 18 (11): 1895–1899. doi:10.1128/CVI.05228-11. ISSN 1556-679X. PMC 3209034. PMID 21918114. Check date values in:
|date=(help) - ↑ Fatha, Noorul; Ang, Li Wei; Goh, Kee Tai (2014-05). "Changing seroprevalence of varicella zoster virus infection in a tropical city state, Singapore". International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases. 22: 73–77. doi:10.1016/j.ijid.2013.10.003. ISSN 1878-3511. PMID 24269652. Check date values in:
|date=(help) - ↑ Bradley, Heather; Markowitz, Lauri E.; Gibson, Theda; McQuillan, Geraldine M. (February 1, 2014). "Seroprevalence of herpes simplex virus types 1 and 2--United States, 1999-2010". The Journal of Infectious Diseases. 209 (3): 325–333. doi:10.1093/infdis/jit458. ISSN 1537-6613. PMID 24136792.
- ↑ Clark, D. A.; Freeland, M. L.; Mackie, L. K.; Jarrett, R. F.; Onions, D. E. (1993-07). "Prevalence of antibody to human herpesvirus 7 by age". The Journal of Infectious Diseases. 168 (1): 251–252. doi:10.1093/infdis/168.1.251. ISSN 0022-1899. PMID 8390545. Check date values in:
|date=(help)
