List of abnormal findings in chronic fatigue syndrome and myalgic encephalomyelitis

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Myalgic encephalomyelitis/chronic fatigue syndrome is a complex multi-system disease and biological abnormalities in patients have been found affecting multiple bodily systems. No single biomarker-based diagnostic test has been validated but patients have a range abnormal physical findings affecting multiple bodily systems.[1] The CDC states that diagnosing ME/CFS relies on a physical and psychiatric assessment, observations, medical history, clinical interview, and results from a mix of blood and urine tests.[2]

Nervous system[edit | edit source]

Brain[edit | edit source]

  • Progressive brain changes[3]

Central nervous system[edit | edit source]

Autonomic nervous system[edit | edit source]

Peripheral nervous system[edit | edit source]

Muscular system[edit | edit source]

Immune system[edit | edit source]

Immune dysregulation[edit | edit source]

Chronic infection[edit | edit source]

Lymphatic system[edit | edit source]

Cardiovascular system[edit | edit source]

Heart[edit | edit source]

Circulation[edit | edit source]

Blood vessels[edit | edit source]

Blood[edit | edit source]

Digestive system[edit | edit source]

Gastrointestinal tract[edit | edit source]


Liver[edit | edit source]

Nutrition[edit | edit source]

Metabolism[edit | edit source]

  • Metabolic abnormalities in chronic fatigue syndrome/myalgic encephalomyelitis: a mini-review[72]

Cellular respiration[edit | edit source]

Exercise[edit | edit source]

  • reduced pain threshold[80]
  • translocation of bacteria[81]
  • loss of capacity to recover from acidosis on repeat exercise[82]
  • increased expression of sensory, adrenergic and immune genes following muscle exertion[83][84][85]
  • decreased oxygen utilization[86]
Abnormal findings in Chronic fatigue syndrome and myalgic encephalomyelitis. There is no single biomarker, but tests have found differences in blood flow to the brain, hand grip strength, metabolite and mitochondria abnormalities, reduced heart output, white and red blood cell differences, reduced blood volume, differences in gut bacteria, neuroinflammation, abnormal responses to exercise, and other abnormalities.

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, ACP; Speight, N; Vallings, R; Bateman, L; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Gerken, A; Jo, D; Lewis, DP; Light, AR; Light, KC; Marshall-Gradisnik, S; McLaren-Howard, J; Mena, I; Miwa, K; Murovska, M; Stevens, SR (2012), Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners (PDF), ISBN 978-0-9739335-3-6
  2. https://www.cdc.gov/me-cfs/symptoms-diagnosis/diagnosis.html
  3. Shan, Zack Y.; Kwiatek, Richard; Burnet, Richard; Fante, Peter Del; Staines, Donald R.; Marshall‐Gradisnik, Sonya M.; Barnden, Leighton R. (2016). "Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study". Journal of Magnetic Resonance Imaging. 44 (5): 1301–1311. doi:10.1002/jmri.25283. ISSN 1522-2586. PMC 5111735. PMID 27123773.
  4. 4.0 4.1 Mathew, Sanjay J.; Mao, Xiangling; Keegan, Kathryn A.; Levine, Susan M.; Smith, Eric L. P.; Heier, Linda A.; Otcheretko, Viktor; Coplan, Jeremy D.; Shungu, Dikoma C. (April 2009). "Ventricular cerebrospinal fluid lactate is increased in chronic fatigue syndrome compared with generalized anxiety disorder: anin vivo3.0 T1H MRS imaging study". NMR in Biomedicine. 22 (3): 251–258. doi:10.1002/nbm.1315. ISSN 0952-3480.
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