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Levothyroxine
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{{stub}} Levothyroxine is a thyroid medicine used as hormone replacement therapy for those diagnosed with [[Hashimoto's thyroiditis (hypothyroidism)|hypothyroidism]] (underactive thyroid gland). The most common cause of hypothyroidism is [[Hashimoto's thyroiditis (hypothyroidism)|Hashimoto's thyroiditis]].<ref name=":0">{{Cite web|url=https://www.thyroid.org/hashimotos-thyroiditis/ | title = Hashimoto’s Thyroiditis|website=American Thyroid Association|language=en-US|access-date=2020-10-18}}</ref> The thyroid gland is responsible for producing thyroxine (T4). If the thyroid is not producing enough T4, then the synthetic hormone Levothyroxine is taken to replace the missing hormone.<ref name=":0" /> == Theory == The addition of synthetic thyroid hormone compensates for an underactive thyroid gland. This can control hypothyroid symptoms like low energy, but is not a cure.<ref>{{Cite web|url=https://medlineplus.gov/druginfo/meds/a682461.html | title = Levothyroxine: MedlinePlus Drug Information|website=medlineplus.gov|language=en|access-date=2020-10-31}}</ref> == Evidence == Levothyroxine has been around for many years treating patients with an underactive thyroid. It has substantially improved the lives of millions of hypothyroid patients since its introduction in 1949.<ref>{{Cite journal | last = Duntas | first = Leonidas H. | last2 = Jonklaas | first2 = Jacqueline | date = 2019-09-01 | title = Levothyroxine Dose Adjustment to Optimise Therapy Throughout a Patient’s Lifetime|url=https://doi.org/10.1007/s12325-019-01078-2|journal=Advances in Therapy|language=en|volume=36|issue=2 | pages = 30–46|doi=10.1007/s12325-019-01078-2|issn=1865-8652|pmc = 6822824|pmid=31485977}}</ref> == Clinicians == == Risks and safety == == Costs and availability == == Lingering symptoms == Levothyroxine is prescribed to treat hypothyroidism (low thyroid hormone). Physicians often adjust dosage in an effort to normalize thyroid-stimulating hormone (TSH) levels. However, many patients report no change in symptoms, even after thyroid medication has lowered their TSH to normal levels.<ref>{{Cite web|url=https://www.sciencedaily.com/releases/2016/10/161012132038.htm | title = Hypothyroidism symptoms linger despite medication use, normal blood tests | last = | first = | authorlink = | date = October 12, 2016 | website = |archive-url=|archive-date=|url-status=|access-date=}}</ref> == See also == * [[Hashimoto's thyroiditis (hypothyroidism)]] * [[Thyroid hormone]] == References == {{Reflist}} [[Category:Potential treatments]]
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