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Leslie Simpson
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=== Ramsay's disease === In 2013 Simpson published a book with ME-patients and psychotherapist [[Nancy Blake]] called [[Ramsay's Disease - Myalgic Encephalomyelitis (ME) and the Unfortunate Creation of 'CFS'|''Ramsay’s disease: Myalgic Encephalomyelitis (ME) and the Unfortunate Creation of 'CFS'''.]] In the book Simpson explains his theory of red blood cell deformability and capillary restriction in ME. He thinks this biological mechanism could account for the characteristic relapsing course Melvin Ramsay noted in patients with ME. According to Simpson “It would be very difficult to imagine a disease process caused by a persistent viral infection or a persisting immunological aberration, which allowed a return to normality for hour, days or weeks.” Although Simpson thinks erythrocyte deformability is a key element of ME he does not see it as something unique to this disease. He wrote that “the changes in red cell shape populations which occur in ME also occur in other chronic disorders so red cell shape analysis alone is not diagnostic for ME. The observed changes are probably of importance in the pathogenesis of tiredness.”<ref name=":0">Simpson LO. Myalgic Encephalomyelitis (ME): [http://orthomolecular.org/library/jom/1997/pdf/1997-v12n02-p069.pdf A Haemorheological Disorder Manifested as Impaired Capillary Blood Flow.] Journal of Orthomolecular Medicine. 1997;12(2):69-76. </ref> Simpson had previously reported about red blood cell changes in multiple sclerosis and other diseases. Simpson does thinks red cell deformity is an important pathological mechanism in ME and he recommended research into treatment, to focus on the issue of blood circulation. Simpson suggested that [[evening primrose oil]] could improve the flow properties of blood.<ref name=":0" />
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