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Ketogenic diet
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=== Neurodegenerative Disease === There is evidence from uncontrolled clinical trials and animal models that ketogenic diets may be protective in neurodegenerative disorders including [[Alzheimer's|Alzheimer's disease]] and [[Parkinson's disease]].<ref name="Gasior2006" /> Mice fed a ketogenic diet had increased activity of [[dopamine]]rgic neurons.<ref name="ChurchWH2014" /> In a rat model of Parkinson's, a ketogenic diet was protective against neurotoxicity by up-regulating glutathione.<ref name="ChengB2009" /> A clinical trial of Parkinson’s disease compared a ketogenic diet to a low-fat diet with improvement in motor symptoms in both groups after 8 weeks but greater improvement in non-motor symptoms (fatigue, pain, and cognitive impairment) in the ketogenic group. <ref>{{Cite journal | last = Phillips | first = Matthew C.L. | last2 = Murtagh | first2 = Deborah K.J. | last3 = Gilbertson | first3 = Linda J. | last4 = Asztely | first4 = Fredrik J.S. | last5 = Lynch | first5 = Christopher D.P. | date = Aug 2018 | title = Low-fat versus ketogenic diet in Parkinson's disease: A pilot randomized controlled trial | url = https://www.ncbi.nlm.nih.gov/pubmed/30098269/|journal=Movement Disorders: Official Journal of the Movement Disorder Society|volume=33|issue=8|pages=1306–1314|doi=10.1002/mds.27390|issn=1531-8257|pmc=6175383|pmid=30098269}}</ref> Another study found dietary ketosis enhanced memory in patients with mild cognitive impairment.<ref name="Krikorian2012" />
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