Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Ken Lassesen's model
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
'''Ken Lassesen''' is a mathematician and software engineer who first became ill with [[chronic fatigue syndrome]] in 1972, then 2001, 2012. Each recovery was connected to a treatment that would have altered [[gut microbiome]] (although that was not the intended target for the first two recoveries). He believes the symptoms of CFS are caused by gut [[dysbiosis]] because it meets Osler criteria -- the simplest model that is consistent with all of the observations.{{Citation needed}} He outlines his model in a paper.<ref>[https://cfsremission.files.wordpress.com/2016/02/english.pdf Remissions from Chronic Fatigue Syndrome - CFS for NDs, Patients and Evidence based MDs - 2012]</ref> ==Theory== Lasses theorizes that CFS is caused by a shift in gut bacteria. <ref>https://cfsremission.wordpress.com/2015/10/04/latest-model-on-what-cfs-is-and-implication-for-treatment/</ref>. This shift can have many causes including [[stress]], [[virus|viral infection]], [[bacteria|bacterial infection]], and [[vaccine|immunization]]. The shift in gut bacteria also alters host ability to extract and process nutrients, leading to deficiencies in key [[amino acid]]s, [[vitamin]]s, and [[mineral]]s. Variation between patients in the population of gut bacteria explains the heterogeneity of symptoms. ===Gut Bacteria Shifts Seen=== The model is based on the shifts reported in 1998<ref>http://www.ahmf.org/98access/98butt3.html</ref> and 2001<ref>http://www.ahmf.org/01access/01schloeffel.html</ref> at Australian CFS/ME Clinical and Scientific Meeting. He has produced a matrix showing how certain anti-pathogens impacts the 6 key bacteria shifts reported in the literature. {| class="wikitable" |Gut Bacteria |Klebsiella/Enterobacter |Enterococcus |[[Streptococcus]] |[[E. coli|E.Coli]] |[[bifidobacteria|Bifidobacterium]] |[[Lactobacillus]] |Score for CFS |- |Levels in CFS Patients |HIGH |HIGH |HIGH |low |low |low * |- |Tetracyclines |Effective |Resistant |Resistant |Resistant |Resistant |Resistant |1 |- |Macrolides |Effective |Resistant |Resistant |Resistant |Resistant |Resistant |1 |- |Quinolone |Resistant |Effective |Resistant |Resistant |Resistant |Effective |- 1 |- |Metronidazole |Effective |Resistant |Resistant |Effective |Resistant |Resistant |- 1 |- |Amoxycillin |Resistant |Effective |Effective |Resistant |Effective |Effective |- 2 |- |Silver |Resistant |Effective |Effective |Resistant |Effective |Effective |- 2 |- |[[probiotic|Lactobacillus probiotics]] |Resistant |Resistant |Effective |Effective |Effective | n/a |- 3 |} Scoring done by 1 for each EFFECTIVE in high (good) and -2 for each EFFECTIVE in low (the harm is more significant than the good). Postive scores are desired<ref>https://cfsremission.wordpress.com/2013/12/26/why-jadins-antibiotics-protocol-usually-work-pasteur-institute-got-the-solution-right-and-the-explanation-wrong/</ref> ===Hypercoagulation=== Lassesen also emphasizes [[hypercoagulation]] as a major factor in CFS, which in his case is at least in part genetic.<ref>https://cfsremission.wordpress.com/2015/12/08/restore-for-gut-health-danger-will-robinson/</ref> ==Treatment== Lasses theorizes that a variety of [[probiotic]]s may be of benefit in correcting the dysbosis along with herbal and pharmaceutical [[antibiotic]]s. The success of treatment and the specific strains most likely to be effective may depend in part on the specific profile of a patient's gut bacteria, which is impossible to fully characterize under existing measurement techniques. However, Lassesen cites several small studies indicating CFS patients may have low populations of [[bifidobacterium]], [[lactobacillus]] and [[escherichia coli]].{{Citation needed}} He recommends strict avoidance of any [[lactobacillus acidophilus]] containing probiotics or yogurts and other lactic acid producing strains. And he recommends the use of [[bifidobacterium]]-only products as well as [[Align]], [[Mutaflor]], [[Miyarisan]] and [[Prescript Assist]]. ==Evidence== While there has a been no research on the application of Lassesen's theory in CFS patients, there is some research in CFS and more extensive research in [[irritable bowel syndrome]] supporting aspects of his approach. In early 2016 a web-based study will begin through [[Mendus]] wherein ME/CFS patients can participate in a study that will address aspects of Lassesen's (and others) thoughts concerning gut dysbiosis. ===Chronic fatigue syndrome=== One study found increased d-lactic acid intestinal bacteria in CFS patients.<ref>http://www.ncbi.nlm.nih.gov/pubmed/19567398</ref> ==See also== *[[Gut microbiome]] *[[Dysbiosis]] *[[Probiotics]] *[[Dr Markov's chronic bacterial intoxication syndrome (CBIS) theory of ME/CFS]] ==Learn more== *[https://cfsremission.wordpress.com CFS Remission blog] ==References== {{reflist}} [[Category:Medical hypotheses]] [[Category:Protocols]]
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Templates used on this page:
Template:Category handler
(
edit
)
Template:Citation needed
(
edit
)
Template:Colon
(
edit
)
Template:Fix
(
edit
)
Template:Fix/category
(
view source
) (protected)
Template:GetFallback
(
edit
)
Template:LangSwitch
(
edit
)
Template:Main other
(
edit
)
Template:Reflist
(
edit
)
Template:Uselang
(
edit
)
Module:Arguments
(
edit
)
Module:Category handler
(
edit
)
Module:Category handler/blacklist
(
edit
)
Module:Category handler/config
(
edit
)
Module:Category handler/data
(
edit
)
Module:Category handler/shared
(
edit
)
Module:Check for unknown parameters
(
edit
)
Module:Namespace detect/config
(
edit
)
Module:Namespace detect/data
(
edit
)
Module:Unsubst
(
edit
)
Module:Yesno
(
edit
)
This page is a member of 2 hidden categories:
Category:All articles with unsourced statements
Category:Articles with unsourced statements from unknown year
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs