Kelly Ickmans

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Kelly Ickmans is assistant professor and postdoctoral researcher at the Vrije Universiteit Brussel and physiotherapist at the University Hospital Brussels, Belgium.[1][2] She is a member of the Pain in Motion research group.[2]

Notable studies[edit | edit source]

  • 2011, Treatment of central sensitization in patients with 'unexplained' chronic pain: what options do we have?[3] - (Full text)
  • 2011, Serotonergic descending inhibition in chronic pain: design, preliminary results and early cessation of a randomized controlled trial[4] - (Full text)
  • 2012, Pain in patients with chronic fatigue syndrome: time for specific pain treatment?[5] - (Abstract)
  • 2012, How to exercise people with chronic fatigue syndrome: evidence-based practice guidelines[6] - (Full text)
  • 2012, In the mind or in the brain? Scientific evidence for central sensitisation in chronic fatigue syndrome[7] - (Full text)
  • 2012, Ignoring the evidence favouring exercise therapy for chronic fatigue syndrome is unethical and scientifically incorrect[8] - (Full text)
  • 2013, Fear of movement and avoidance behaviour toward physical activity in chronic-fatigue syndrome and fibromyalgia: state of the art and implications for clinical practice[9] - (Abstract)
  • 2013, Association between cognitive performance, physical fitness, and physical activity level in women with chronic fatigue syndrome[10] - (Full text)
  • 2013, Postural orthostatic tachycardia syndrome as a clinically important subgroup of chronic fatigue syndrome: further evidence for central nervous system dysfunctioning[11] - (Abstract)
  • 2013, Does acetaminophen activate endogenous pain inhibition in chronic fatigue syndrome/fibromyalgia and rheumatoid arthritis? A double-blind randomized controlled cross-over trial[12] - (Abstract)
  • 2014, Can recovery of peripheral muscle function predict cognitive task performance in chronic fatigue syndrome with and without fibromyalgia?[13] - (Abstract)
  • 2014, Recovery of upper limb muscle function in chronic fatigue syndrome with and without fibromyalgia[14] - (Abstract)
  • 2014, Treatment of central sensitization in patients with 'unexplained' chronic pain: an update[15] - (Abstract)
  • 2014, Altered immune response to exercise in patients with chronic fatigue syndrome/myalgic encephalomyelitis: a systematic literature review[16] (Full Text)
  • 2016, What is in a name? Comparing diagnostic criteria for chronic fatigue syndrome with or without fibromyalgia[17] - (Abstract)
  • 2017, Endogenous Pain Facilitation Rather Than Inhibition Differs Between People with Chronic Fatigue Syndrome, Multiple Sclerosis, and Controls: An Observational Study[18] - (Full Text)
  • 2018, Cerebral Blood Flow and Heart Rate Variability in Chronic Fatigue Syndrome: A Randomized Cross-Over Study[19] - (Full text)
  • 2018, Exercise-induce hyperalgesia, complement system and elastase activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - a secondary analysis of experimental comparative studies[20] - (Full text)
  • 2019, Relationship Between Exercise-induced Oxidative Stress Changes and Parasympathetic Activity in Chronic Fatigue Syndrome: An Observational Study and in Patients and Healthy Subjects[21] - (Full text)
  • 2019, Treatment of central sensitization in patients with chronic pain: time for change?[22] - (Full text)
  • 2020, DNA Methylation and Brain‐Derived Neurotrophic Factor Expression Account for Symptoms and Widespread Hyperalgesia in Patients With Chronic Fatigue Syndrome and Comorbid Fibromyalgia[23] - (Full text)
  • 2021, Central sensitisation in chronic pain conditions: latest discoveries and their potential for precision medicine[24] - (Full text)
2021, Central sensitisation: causes, therapies, and terminology – Authors' reply[25] - (Letter, Full text)
  • 2019, Relationship Between Exercise-induced Oxidative Stress Changes and Parasympathetic Activity in Chronic Fatigue Syndrome: An Observational Study and in Patients and Healthy Subjects[26]

Online presence[edit | edit source]

References[edit | edit source]

  1. ↑ "Kelly Ickmans". Researchgate. Retrieved January 9, 2019.
  2. ↑ 2.0 2.1 "Members". Pain in Motion (in Nederlands). Retrieved January 9, 2019.
  3. ↑ Nijs, Jo; Meeus, Mira; Van Oosterwijck, Jessica; Roussel, Nathalie; De Kooning, Margot; Ickmans, Kelly; Matic, Milica (May 2011). "Treatment of central sensitization in patients with 'unexplained' chronic pain: what options do we have?". Expert Opinion on Pharmacotherapy. 12 (7): 1087–1098. doi:10.1517/14656566.2011.547475. ISSN 1744-7666. PMID 21254866.
  4. ↑ Meeus, Mira; Ickmans, Kelly; Clerck, Luc S. De; Moorkens, Greta; Hans, Guy; Grosemans, Sofie; Nijs, Jo (November 1, 2011). "Serotonergic Descending Inhibition in Chronic Pain: Design, Preliminary Results and Early Cessation of a Randomized Controlled Trial". In Vivo. 25 (6): 1019–1025. ISSN 0258-851X. PMID 22021700.
  5. ↑ Pain in patients with chronic fatigue syndrome: time for specific pain treatment? Pain Physician. 2012 Sep-Oct;15(5):E677-86
  6. ↑ Van Cauwenbergh, Deborah; De Kooning, Margot; Ickmans, Kelly; Nijs, Jo (June 23, 2012). "How to exercise people with chronic fatigue syndrome: evidence-based practice guidelines". European Journal of Clinical Investigation. 42 (10): 1136–1144. doi:10.1111/j.1365-2362.2012.02701.x. ISSN 0014-2972.
  7. ↑ Nijs, Jo; Meeus, Mira; Van Oosterwijck, Jessica; Ickmans, Kelly; Moorkens, Greta; Hans, Guy; De Clerck, Luc S. (February 2012). "In the mind or in the brain? Scientific evidence for central sensitisation in chronic fatigue syndrome: CENTRAL SENSITISATION IN CFS". European Journal of Clinical Investigation. 42 (2): 203–212. doi:10.1111/j.1365-2362.2011.02575.x.
  8. ↑ Nijs, Jo; Van Cauwenbergh, Deborah; De Kooning, Margot; Ickmans, Kelly (September 8, 2012). "Ignoring the evidence favouring exercise therapy for chronic fatigue syndrome is unethical and scientifically incorrect". European Journal of Clinical Investigation. 42 (11): 1257–1258. doi:10.1111/j.1365-2362.2012.02716.x. ISSN 0014-2972.
  9. ↑ Nijs, Jo; Roussel, Nathalie; Van Oosterwijck, Jessica; De Kooning, Margot; Ickmans, Kelly; Struyf, Filip; Meeus, Mira; Lundberg, Mari (August 2013). "Fear of movement and avoidance behaviour toward physical activity in chronic-fatigue syndrome and fibromyalgia: state of the art and implications for clinical practice". Clinical Rheumatology. 32 (8): 1121–1129. doi:10.1007/s10067-013-2277-4. ISSN 1434-9949. PMID 23639990.
  10. ↑ Ickmans, Kelly; Clarys, Peter; Nijs, Jo; Meeus, Mira; Aerenhouts, Dirk; Zinzen, Evert; Aelbrecht, Senne; Meersdom, Geert; Lambrecht, Luc; Pattyn, Nathalie (2013). "Association between cognitive performance, physical fitness, and physical activity level in women with chronic fatigue syndrome" (PDF). Journal of Rehabilitation Research and Development. 50 (6): 795–810. doi:10.1682/JRRD.2012.08.0156. ISSN 1938-1352. PMID 24203542.
  11. ↑ Nijs, J.; Ickmans, K. (February 8, 2013). "Postural orthostatic tachycardia syndrome as a clinically important subgroup of chronic fatigue syndrome: further evidence for central nervous system dysfunctioning". Journal of Internal Medicine. 273 (5): 498–500. doi:10.1111/joim.12034. ISSN 0954-6820.
  12. ↑ Meeus, Mira; Ickmans, Kelly; Struyf, Filip; Hermans, Linda; Van Noesel, Kevin; Oderkerk, Jorinde; Declerck, Luc S.; Moorkens, Greta; Hans, Guy; Grosemans, Sofie; Nijs, Jo (March 2013). "Does acetaminophen activate endogenous pain inhibition in chronic fatigue syndrome/fibromyalgia and rheumatoid arthritis? A double-blind randomized controlled cross-over trial". Pain Physician. 16 (2): E61–70. ISSN 2150-1149. PMID 23511692.
  13. ↑ Ickmans, Kelly; Meeus, Mira; De Kooning, Margot; Lambrecht, Luc; Pattyn, Nathalie; Nijs, Jo (April 2014). "Can recovery of peripheral muscle function predict cognitive task performance in chronic fatigue syndrome with and without fibromyalgia?". Physical Therapy. 94 (4): 511–522. doi:10.2522/ptj.20130367. ISSN 1538-6724. PMID 24363336.
  14. ↑ Ickmans, Kelly; Meeus, Mira; De Kooning, Margot; Lambrecht, Luc; Nijs, Jo (December 9, 2013). "Recovery of upper limb muscle function in chronic fatigue syndrome with and without fibromyalgia". European Journal of Clinical Investigation. 44 (2): 153–159. doi:10.1111/eci.12201. ISSN 0014-2972.
  15. ↑ Nijs, Jo; Malfliet, Anneleen; Ickmans, Kelly; Baert, Isabel; Meeus, Mira (August 1, 2014). "Treatment of central sensitization in patients with 'unexplained' chronic pain: an update". Expert Opinion on Pharmacotherapy. 15 (12): 1671–1683. doi:10.1517/14656566.2014.925446. ISSN 1465-6566. PMID 24930805.
  16. ↑ Nijs, J; Nees, A; Paul, L; De Kooning, M; Ickmans, K; Meeus, M; Van Oosterwijck, J (2014). "Altered immune response to exercise in patients with chronic fatigue syndrome/myalgic encephalomyelitis: a systematic literature review". Exercise Immunology Review (20): 94-116. PMID 24974723.
  17. ↑ Meeus, Mira; Ickmans, Kelly; Struyf, Filip; Kos, Daphne; Lambrecht, Luc; Willekens, Barbara; Cras, Patrick; Nijs, Jo (January 2016). "What is in a name? Comparing diagnostic criteria for chronic fatigue syndrome with or without fibromyalgia". Clinical Rheumatology. 35 (1): 191–203. doi:10.1007/s10067-014-2793-x. ISSN 1434-9949. PMID 25308475.
  18. ↑ Polli, Andrea; Willekens, Barbara; Meeus, Mira; Nijs, Jo; Collin, Simon M.; Ickmans, Kelly (2017). "Endogenous Pain Facilitation Rather Than Inhibition Differs Between People with Chronic Fatigue Syndrome, Multiple Sclerosis, and Controls: An Observational Study Observational Study". Pain Physician. 20 (4): E489-E497. PMID 28535557.
  19. ↑ Malfliet, A; Pas, R; Brouns, R; De Win, J; Hatem, SM; Meeus, M; Ickmans, K; van Hooff, RJ; Nijs, J (2018). "Cerebral Blood Flow and Heart Rate Variability in Chronic Fatigue Syndrome: A Randomized Cross-Over Study". Pain Physician. 21 (1): E13-E24.
  20. ↑ Polli, Andrea; Van Oosterwijck, Jessica; Meeus, Mira; Lambrecht, Luc; Nijs, Jo; Ickmans, Kelly (October 16, 2018). "Exercise-induce hyperalgesia, complement system and elastase activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome – a secondary analysis of experimental comparative studies". Scandinavian Journal of Pain. 19 (1): 183–192. doi:10.1515/sjpain-2018-0075. ISSN 1877-8879.
  21. ↑ Ickmans, Kelly; Lambrecht, Luc; Moorkens, Greta; Meeus, Mira; Paul, Lorna; Wandele, Inge De; Marusic, Uros; Nijs, Jo; Oosterwijck, Jessica Van (January 18, 2019). "Relationship Between Exercise-induced Oxidative Stress Changes and Parasympathetic Activity in Chronic Fatigue Syndrome: An Observational Study and in Patients and Healthy Subjects". Clinical Therapeutics. doi:10.1016/j.clinthera.2018.12.012. ISSN 0149-2918. PMID 30665828.
  22. ↑ Nijs, Jo; Leysen, Laurence; Vanlauwe, Johan; Logghe, Tine; Ickmans, Kelly; Polli, Andrea; Malfliet, Anneleen; Coppieters, Iris; Huysmans, Eva (November 2, 2019). "Treatment of central sensitization in patients with chronic pain: time for change?". Expert Opinion on Pharmacotherapy. 20 (16): 1961–1970. doi:10.1080/14656566.2019.1647166. ISSN 1465-6566. PMID 31355689.
  23. ↑ Polli, Andrea; Ghosh, Manosij; Bakusic, Jelena; Ickmans, Kelly; Monteyne, Dora; Velkeniers, Brigitte; Bekaert, Bram; Godderis, Lode; Nijs, Jo (October 7, 2020). "DNA Methylation and Brain‐Derived Neurotrophic Factor Expression Account for Symptoms and Widespread Hyperalgesia in Patients With Chronic Fatigue Syndrome and Comorbid Fibromyalgia". Arthritis & Rheumatology. 72 (11): 1936–1944. doi:10.1002/art.41405. ISSN 2326-5191.
  24. ↑ Nijs, Jo; George, Steven Z.; Clauw, Daniel J.; Fernández-de-las-Peñas, César; Kosek, Eva; Ickmans, Kelly; Fernández-Carnero, Josué; Polli, Andrea; Kapreli, Eleni; Huysmans, Eva; Cuesta-Vargas, Antonio I. (May 1, 2021). "Central sensitisation in chronic pain conditions: latest discoveries and their potential for precision medicine". The Lancet Rheumatology. 3 (5): e383–e392. doi:10.1016/S2665-9913(21)00032-1. ISSN 2665-9913.
  25. ↑ Nijs, Jo; George, Steven Z.; Clauw, Daniel J.; Fernández-de-las-Peñas, César; Kosek, Eva; Ickmans, Kelly; Carnero, Josué Fernández; Polli, Andrea; Kapreli, Eleni; Huysmans, Eva; Cuesta-Vargas, Antonio I. (August 1, 2021). "Central sensitisation: causes, therapies, and terminology – Authors' reply". The Lancet Rheumatology. 3 (8): e548–e549. doi:10.1016/S2665-9913(21)00182-X. ISSN 2665-9913. PMID 28339438.
  26. ↑ Ickmans, Kelly; Lambrecht, Luc; Moorkens, Greta; Meeus, Mira; Paul, Lorna; Wandele, Inge De; Marusic, Uros; Nijs, Jo; Oosterwijck, Jessica Van (January 18, 2019). "Relationship Between Exercise-induced Oxidative Stress Changes and Parasympathetic Activity in Chronic Fatigue Syndrome: An Observational Study and in Patients and Healthy Subjects". Clinical Therapeutics. doi:10.1016/j.clinthera.2018.12.012. ISSN 0149-2918. PMID 30665828.

cognition Thought processes, including attention, reasoning, and memory.

postural orthostatic tachycardia syndrome (POTS) - A form of orthostatic intolerance where the cardinal symptom is excessive tachycardia due to changing position (e.g. from lying down to sitting up).

central nervous system (CNS) - One of the two parts of the human nervous system, the other part being the peripheral nervous system. The central nervous system consists of the brain and spinal cord, while the peripheral nervous system consists of nerves that travel from the central nervous system into the various organs and tissues of the body.

endogenous Growing or originating from within an organism.

double blinded trial A clinical trial is double blinded if neither the participants nor the researchers know which treatment group they are allocated to until after the results are interpreted. This reduces bias. (Learn more: www.nottingham.ac.uk)

endogenous Growing or originating from within an organism.

cerebral 1. of or relating to the brain or the intellect 2. of, relating to, affecting, or being the cerebrum.

heart rate variability (HRV) - A measurement of the variability of the heart rate over time. When the heart rate is consistent, there will be a low heart rate variability. When the heart rate is constantly changing, there will be a high heart rate variability. Heart rate variability is often used by ME/CFS patients to monitor their autonomic nervous system, as high heart rate variability is associated with the sympathetic nervous system and low heart rate variability is associated with the parasympathetic nervous system.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

stress Stress can by either physical or psychological, or both. Stress is either 1) a state of emotional or psychological strain or 2) the physical stress (pressure or tension) that a physical object such the human body is placed under, e.g., a stress test is a medical test that monitors the cardiovascular system during strenuous exercise.

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