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[[File:Dr. Chia .png|thumb|right|Source: MECFS Alert]] Dr. '''John K. S. Chia''' is an infectious disease doctor with a medical practice in Torrance, California. Dr. Chia became heavily involved in research and clinical care of [[myalgic encephalomyelitis]] (ME) and [[chronic fatigue syndrome]] (CFS) patients after his son, [[Andrew Chia]], became ill with [[chronic fatigue syndrome|CFS]] in 1997. He has published several papers<ref>http://www.ncbi.nlm.nih.gov/pubmed/?term=chia+jk%5Bauthor%5D</ref> on infectious causes of ME and CFS, including evidence of involvement of [[enteroviruses]] such as [[coxsackie B]] and [[echovirus]], other viruses such as [[parvovirus B19]], as well as bacteria such as ''[[Chlamydia pneumoniae]]''. In addition to his clinical work, he runs his own [[enterovirus]] research laboratory<ref>[http://www.evmedresearch.com/ EVMED Research]</ref> and is on the board of directors of the [http://www.enterovirusfoundation.org/ Enterovirus Foundation]. Dr. Chia has performed clinical trials<ref>[http://jrnlappliedresearch.com/articles/Vol4Iss2/Chia2-Jar-spring.pdf Ribavirin and Interferon-a for the Treatment of Patients with Chronic Fatigue Syndrome Associated with Persistent Coxsackievirus B Infection: A Preliminary Observation]</ref> in an attempt to find treatment for patients with [[myalgic encephalomyelitis|ME]] and [[chronic fatigue syndrome|CFS]]. His treatment attempts have focused on the use of antiviral compounds such as [[amantadine]], [[ribavirin]], and [[lamivudine]] in addition to immune modulators such as [[interferon]] and the plant compound [[oxymatrine]]. Towards this end, he and his son, a pharmacist, have developed his own proprietary herbal preparation containing oxymatrine and other plant compounds, called [[Equilibrant]]. ==International Consensus Criteria== Dr. Chia co-authored the 2011 case definition, [[International Consensus Criteria]].<ref>{{Cite journal | last = Carruthers | first = Bruce M. | authorlink = Bruce Carruthers | last2 = van de Sande | first2 = Marjorie I. | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = Kenny L. | authorlink3 = Kenny De Meirleir | last4 = Klimas | first4 = Nancy G. | author-link4 = Nancy Klimas | last5 = Broderick | first5 = Gordon | authorlink5 = Gordon Broderick | last6 = Mitchell | first6 = Terry | authorlink6 = Terry Mitchell | last7 = Staines | first7 = Donald | author-link7 = Donald Staines | last8 = Powles | first8 = A.C. Peter | authorlink8 = A C Peter Powles | last9 = Speight | first9 = Nigel | authorlink9 = Nigel Speight | last10 = Vallings | first10 = Rosamund | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = Lucinda | authorlink11 = Lucinda Bateman | last12 = Baumgarten-Austrheim | first12 = Barbara | authorlink12 = Barbara Baumgarten-Austrheim | last13 = Bell | first13 = David | author-link13 = David Bell | last14 = Carlo-Stella | first14 = Nicoletta | author-link14 = Nicoletta Carlo-Stella | last15 = Chia | first15 = John | author-link15 = John Chia | last16 = Darragh | first16 = Austin | author-link16 = Austin Darragh | last17 = Jo | first17 = Daehyun | author-link17 = Daehyun Jo | last18 = Lewis | first18 = Donald | author-link18 = Donald Lewis | last19 = Light | first19 = Alan | author-link19 = Alan Light | last20 = Marshall-Gradisnik | first20 = Sonya | author-link20 = Sonya Marshall-Gradisnik | last21 = Mena | first21 = Ismael | author-link21 = Ismael Mena | last22 = Mikovits | first22 = Judy | author-link22 = Judy Mikovits | last23 = Miwa | first23 = Kunihisa | author-link23 = Kunihisa Miwa | last24 = Murovska | first24 = Modra | author-link24 = Modra Murovska | last25 = Pall | first25 = Martin | author-link25 = Martin Pall | last26 = Stevens | first26 = Staci | author-link26 = Staci Stevens | date = 2011-08-22 | title=Myalgic encephalomyelitis: International Consensus Criteria | url = https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4 | pages = 327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref> ==Open Letter to ''The Lancet''== Three [[open letter to the Lancet | open letters to the editor of ''The Lancet'']] urged the editor to commission a fully independent review of the [[PACE trial]], which the journal had published in 2011. In 2016, Dr. Chia, along with 41 colleagues in the [[ME/CFS]] field, signed the second letter. In 2018, Dr. Chia was joined with over 100 signatories. *February 10, 2016, [http://www.virology.ws/2016/02/10/open-letter-lancet-again/ An open letter to The Lancet, again - Virology blog]<ref>{{Cite web | url = http://www.virology.ws/2016/02/10/open-letter-lancet-again | title = An open letter to The Lancet, again | last = Tuller | first = David | date = February 10, 2016 | website = [[Virology blog]]|archive-url=|archive-date=|url-status=|access-date=}}</ref> *June 19, 2018, [http://www.virology.ws/2018/06/19/trial-by-error-an-open-letter-to-the-lancet-two-years-on/ An Open Letter to The Lancet, Two Years On]<ref>{{Cite web | url = http://www.virology.ws/2018/06/19/trial-by-error-an-open-letter-to-the-lancet-two-years-on/ | title = Trial By Error: An Open Letter to The Lancet, Two Years On | last = Tuller | first = David | date = Jun 19, 2018 | website = [[Virology blog]]|archive-url=|archive-date=|url-status=|access-date=}}</ref> ==Notable studies== *2004, Ribavirin and [[Interferon]]-α for the Treatment of Patients with [[Chronic Fatigue Syndrome]] Associated with Persistent [[Coxsackie B virus|Coxsackievirus B]] Infection: A Preliminary Observation<ref>{{Cite journal | last = Chia | first = John K | last2 = Chia | first2 = Andrew | authorlink2 = Andrew Chia | date = 2004 | title = Ribavirin and Interferon-α for the Treatment of Patients with Chronic Fatigue Syndrome Associated with Persistent Coxsackievirus B Infection: A Preliminary Observation | url =http://www.jarcet.com/articles/Vol4Iss2/Chia2-Jar-spring.pdf | journal=The Journal of Applied Research|volume=4|issue=2 | pages = 286-292|via=}}</ref> [http://www.jrnlappliedresearch.com/articles/Vol4Iss2/Chia2-Jar-spring.pdf (Full Text)] *2005, The role of [[enterovirus]] in [[chronic fatigue syndrome]]<ref name="pmid16254097">{{cite journal | last = Chia | first = JKS | authorlink = John Chia | title = The role of enterovirus in chronic fatigue syndrome. | journal=J Clin Pathol | year= 2005 | volume= 58 | issue= 11 | pages = 1126-32 | pmid=16254097 | doi=10.1136/jcp.2004.020255 | url=https://jcp.bmj.com/content/58/11/1126}}</ref> [https://jcp.bmj.com/content/58/11/1126 (Full Text)] *2008, [[Chronic fatigue syndrome]] is associated with chronic [[enterovirus]] infection of the stomach<ref>{{Cite journal | last = Chia | first = John | authorlink = John Chia | last2 = Chia | first2 = Andrew | authorlink2 = Andrew Chia | date = 2008 | title = Chronic fatigue syndrome is associated with chronic enterovirus infection of the stomach | url = https://jcp.bmj.com/content/61/1/43|journal=Journal of Clinical Pathology|volume=61|issue=1 | pages = 43-48|quote=|via=}}</ref> [http://jcp.bmj.com/content/61/1/43 (Abstract)] *2010, Antibody to [[parvovirus B19]] nonstructural protein is associated with chronic arthralgia in patients with chronic fatigue syndrome/myalgic encephalomyelitis<ref>{{Cite journal | last = Kerr | first = J.R. | authorlink = Jonathan Kerr | last2 = Gough | first2 = J. | authorlink2 = | last3 = Richards | first3= S.C.M. | authorlink3 = | last4 = Main | first4 = J. | authorlink4 = | last5 = Enlander | first5 =D. | authorlink5 = Derek Enlander | last6 = McCreary | first6 = M. | authorlink6 = | last7 = Komaroff | first7 = A.L. | author-link7 = Anthony Komaroff | last8 = Chia | first8 = J.K. | authorlink8 = John Chia | date = 2010-04-01 | title = Antibody to parvovirus B19 nonstructural protein is associated with chronic arthralgia in patients with chronic fatigue syndrome/myalgic encephalomyelitis | url = http://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.017590-0|journal=Journal of General Virology|language=en|volume=91|issue=4 | pages = 893–897|doi=10.1099/vir.0.017590-0|issn=0022-1317|quote=|via=}}</ref> - [http://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.017590-0#tab2 (Full Text)] *2015, Poster - Dr Chia's ME/CFS post-mortem brain study: Chronic Enterovirus Infection in a Patient With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) – Clinical, Virologic and Pathological Analysis<ref>{{Cite web | url = https://forums.phoenixrising.me/index.php?threads/are-infections-just-a-trigger-of-me-cfs-or-an-ongoing-cause-of-me-cfs.37549/page-25#post-632251 | title = Dr Chia's ME/CFS post-mortem brain study: Chronic Enterovirus Infection in a Patient With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) – Clinical, Virologic and Pathological Analysis. John Chia, David Wang, Andrew Chia, Rabiha El-Habbal, 2015. Presented at the 19th International Picornavirus Meeting, 2016 | last = | first = | date = |website=|archive-url=|archive-date=|url-status=|access-date=}}</ref> *2015, Functional Dyspepsia and Chronic Gastritis Associated with Enteroviruses<ref name="Chia, 2015" /> [http://file.scirp.org/Html/2-1900264_55465.htm (Full Text)] *2022, Plasma metabolomics reveals disrupted response and recovery following maximal exercise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome<ref name="ArnaudPlasma2022">{{Cite journal | title = Plasma metabolomics reveals disrupted response and recovery following maximal exercise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | date = 2022-03-31 | url = https://insight.jci.org/articles/view/157621|journal=JCI Insight|volume=|issue=|pages = | last = Germain | first = Arnaud | authorlink = Arnaud Germain | last2 = Giloteaux | first2 = Ludovic | authorlink2 = Ludovic Giloteaux | last3 = Moore | first3 = Geoffrey E. | authorlink3 = | last4 = Levine | first4 = Susan M. | authorlink4 = Susan Levine | last5 = Chia | first5 = John K. | authorlink5 = John Chia | last6 = Keller | first6 = Betsy A. | authorlink6 = Betsy Keller | last7 = Stevens | first7 = Jared | last8 = Franconi | first8 = Carl J. | last9 = Mao | first9 = Xiangling | last10 = Shungu | first10 = Dikoma C. | authorlink10 = Dikoma Shungu | last11 = Grimson | first11 = Andrew|language=en|doi=10.1172/jci.insight.157621|pmc=|pmid=|access-date=|issn=0021-9738|quote=|via=}}</ref> - [https://insight.jci.org/articles/view/157621/pdf (Full text)] ==Talks and interviews== *2008: [https://www.youtube.com/watch?v=Xz7CaxWtCUU International Symposium on Viruses In CFS, Baltimore 2008:] ''The Role of Enterovirus in ME/CFS'' *2008: [https://www.youtube.com/watch?v=XwuaiO1YFJc Dr John Chia, Invest in ME International ME Conference, London 2008]: ''The Role of Enterovirus in Chronic Fatigue Syndrome / Myalgic Encephalomyelitis '' *2008, [https://www.youtube.com/watch?v=heIqPKCShsY Dr John Chia, Invest in ME International ME Conference, London 2008] Dr John Chia Interview with Professor [[Malcolm Hooper]] *2009: [https://www.youtube.com/watch?v=YSgcNSqssTI Dr John Chia, Invest in ME International ME Conference, London 2009]: ''Diagnosis and Treatment of ME/CFS Associated With Chronic Enterovirus Infection'' *2010: [https://www.youtube.com/watch?v=WAZ4HiSC_sM Dr John Chia, Invest in ME International ME Conference, London 2010:] ''Enterovirus Infection in ME/CFS'' *2011: [https://www.youtube.com/watch?v=XBUfUEwyEIA Dr John Chia, Invest in ME International ME Conference, London 2011:] ''Clinical and Research Experience of Enteroviral Involvement in ME/CFS'' *2011: [https://www.youtube.com/watch?v=obHtCwhg3-0 Dr John Chia State of Knowledge Workshop on ME/CFS Research (Day 1) Part 1] *2011: [https://www.youtube.com/watch?v=BO-yxqZuXTY Dr John Chia State of Knowledge Workshop on ME/CFS Research (Day 1) Part 2] *2011: [https://www.youtube.com/watch?v=Hl69xOZnDJI Dr John Chia State of Knowledge Workshop on ME/CFS Research (Day 2) Review] *2011: [http://phoenixrising.me/interviews-3/the-dr-john-chia-interview-with-cort-johnson-808-introduction The Dr John Chia Interview – Phoenix Rising: Introduction] *2012: [https://www.youtube.com/watch?v=NhU-G0loqtY MECFS Alert Episode 38, part 1 - Interview with Dr. John Chia, Part 1] *2013: [https://www.youtube.com/watch?v=I44G-tGgLNE MECFS Alert Episode 39, part 2 - Interview with Dr. John Chia, Part 2] *2013: [https://www.youtube.com/watch?v=A1h0elEhSO0 MECFS Alert Episode 40, part 3 - Interview with Dr. John Chia, Part 3] *2013: [https://www.youtube.com/watch?v=QGRwyrnuDLs MECFS Alert Episode 41, part 4 - Interview with Dr. John Chia, Part 4] *2015: [https://www.youtube.com/watch?v=IWxqftHYvqU Dr John Chia, Invest in ME International ME Conference, London 2015:] ''Enteroviruses and ME/CFS: An Update on Pathogenesis'' *2016: [https://www.iacfsme.org/assets/docs/IACFSME-2016-Program.pdf 12th International IACFS/ME Biennial Clinical and Research Conference:] ''Acute and Chronic Enteroviral Infection'' *2021: [https://www.youtube.com/watch?v=LSucgoEvoUQ Interview with Amy Proal of the PolyBio Research Foundation: Chronic Enterovirus Infections] ==Media coverage== *2007, [http://www.webmd.com/chronic-fatigue-syndrome/news/20070913/stomach-virus-could-trigger-cfs Stomach Virus Could Trigger CFS. Enterovirus Found in Many Chronic Fatigue Syndrome Sufferers] *2007, [http://www.foxnews.com/story/2007/09/14/study-common-stomach-virus-tied-to-chronic-fatigue.html Study: Common Stomach Virus Tied to Chronic Fatigue] *2009, [https://phoenixrising.me/archives/865 Dr. Chia On Oxymatrine, Autoimmunity, ME/CFS and Fibromyalgia] *2011, [https://phoenixrising.me/interviews-3/an-interview-with-dr-john-chia-m-d-enteroviruses-and-chronic-fatigue-syndrome-part-ii-persistence-treatment-and-the-future-by-cort-johnson An Interview With Dr. John Chia M.D. Enteroviruses and Chronic Fatigue Syndrome Part II: Persistence, Treatment and the Future] *2011, [https://phoenixrising.me/interviews-3/an-interview-with-dr-john-chia-m-d-part-i-by-cort-johnson-808 An Interview With Dr. John Chia, M.D. Part I] *2011, [https://phoenixrising.me/treating-cfs-chronic-fatigue-syndrome-me/immune/antivirals-and-immunemodulators/treating-chronic-fatigue-syndrome-mecfs-interferon Dr Chia's report on the use of interferon to treat ME/CFS] *2011, [https://phoenixrising.me/treating-cfs-chronic-fatigue-syndrome-me/immune/antivirals-and-immunemodulators/oxymatrine Oxymatrine] *February 2013, [http://cfspatientadvocate.blogspot.com/2013/02/hanging-fire-dr-john-chia.html Hanging Fire – Dr. John Chia] ==Publications== *2003, Correspondence in ''Clinical Infectious Diseases'' - "Diverse Etiologies for Chronic Fatigue Syndrome"<ref name="Chia, 2003" /> ==Online presence== *[http://www.cortjohnson.org/chronic-fatigue-syndrome-mecfs-doctor-resource-center/dr-john-chia/ Health Rising profile] *[http://www.ncbi.nlm.nih.gov/pubmed/?term=Chia%20J%5BAuthor%5D&cauthor=true&cauthor_uid=21278394 PubMed] *[http://www.evmedresearch.com/ Website] == See also == * [[Andrew Chia]] * [[Enterovirus]] * [[Equilibrant]] * [[List of enterovirus infection studies]] * [[Non-cytolytic enterovirus]] ==Learn more== *[http://web.archive.org/web/20170227194602/https://med.stanford.edu/chronicfatiguesyndrome/infections/entero/entero-treatment.html Stanford Medicine page on Dr. John Chia] ==References== <references> <ref name="Chia, 2003">{{Citation | last1 = Chia | first1 = John K.S. | authorlink1 = John Chia | last2 =Chia | first2 = Andrew | authorlink2 = | title = Diverse Etiologies for Chronic Fatigue Syndrome | journal = Clinical Infectious Diseases | volume = 36 | issue = 5 | page = 671-672 | date = 2003 | pmid = | doi = 10.1086/367666 }}</ref> <ref name="Chia, 2015">{{Citation | last1 = Chia | first1 = John K. | authorlink1 = John Chia | last2 =Chia | first2 = Andrew Y. | authorlink2 = | last3 =Wang | first3 = David | authorlink3 = | last4 = El-Habbal | first4 = Rabiha | authorlink4 = | title = Functional Dyspepsia and Chronic Gastritis Associated with Enteroviruses | journal = Open Journal of Gastroenterology | volume = 5 | issue = 4 | page = 21-27. | date = 2015 | pmid = | doi = 10.4236/ojgas.2015.54005 }}</ref> </references> [[Category:Researchers]] [[Category:US researchers]] [[Category:Clinicians]] [[Category:American clinicians]] [[Category:California clinicians]] [[Category:Psychological paradigm critics]] [[Category:PACE trial critics]]
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