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Intranasal mechanical stimulation
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{{stub}} '''Intranasal mechanical stimulation''' or '''INMEST''' is a method of stimulating the [[vagus nerve]] from inside the nose.<ref name="Rodriguez2020" /> ==Theory== ==Evidence in ME/CFS== A small placebo-controlled randomized clinical trial by Rodriguez et al. (2020) of moderate and severe patients with [[ME/CFS]] found that a 30% reduction in symptoms was achieved after 8 weeks of INMEST treatment; however the fatigue level of patients did not change.<ref name="Rodriguez2020">{{Cite journal | last = Rodriguez | first = Lucie ST | author-link = Lucie Rodriguez | last2 = Pou | first2 = Christian | authorlink2 = Christian Pou | last3 = Tadepally | first3 = Lakshmikanth | authorlink3 = Lakshmikanth | last4 = Zhang | first4 = Jingdian | authorlink4 = Jingdian Zhang | last5 = Mugabo | first5 = Constantin Habimana | authorlink5 = Constantin Mugabo | last6 = Wang | first6 = Jun | authorlink6 = Jun Wang | last7 = Mikes | first7 = Jaromir | last8 = Olin | first8 = Axel | last9 = Chen | first9 = Yang | date = 2020-02-21 | last10 = Mikes | first10 = Jaromir | first11 = Axel | last11 = Olin | first12 = Yang | last12 = Chen | first13 = Joanna | last13 = Rorbach | first14 = Jan-Erik | last14 = Juto | title = Achieving symptom relief in patients with Myalgic encephalomyelitis by targeting the neuro-immune interface and inducing disease tolerance | url = https://www.biorxiv.org/content/10.1101/2020.02.20.958249v1.full.pdf | journal=bioRxiv|language=en|volume=|issue= | pages = 2020.02.20.958249|doi=10.1101/2020.02.20.958249|pmc=|pmid=|access-date=2020-02-25|quote=|via= | authorlink9 = }}</ref> The trial used patients who fulfilled the [[Canadian Consensus Criteria]].<ref name="Rodriguez2020" /> Dr [[Jan-Erik Juto]], one of the authors of Rodriguez et al. (2020), is a co-founder and stakeholder of Albilion Medical Systems AB, who developed INMEST. ==Clinicians== ==Risks and safety== ==Costs and availability== ==See also== * [[Vagus nerve stimulation]] * [[Vagus nerve]] * [[Autonomic nervous system]] ==Learn more== *[https://www.abilion.com/inmest-intranasal-mechanical-stimulation/ Intranasal Mechanical Stimulation] - Albilion Medical Systems AB ==References== {{reflist}} [[Category:Potential treatments]] [[Category:Electrical and nerve stimulation]]
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