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Interferon
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===Other studies on interferon therapy for ME/CFS === In a 1993 study, 18 ME/CFS patients were given interferon alpha therapy for 12 weeks, after which patients were observed for a further 3 months. Patients were divided into two groups of 9, one group were treated immediately, and the second group had their treatment delayed for 3 months; none of the second group recovered significantly while waiting for treatment. At the end of the study, 3 out of 18 patients recovered completely, and 2 of these 3 remained well 12 months later. A further 2 patients were improved at the end of the 3 month follow-up period and remained so up to 8 months later. Out of the 5 patients who recovered or improved, 4 had coxsackievirus B IgM antibodies in their serum; but only 1 of the patients who did not improve had coxsackievirus B antibodies, which suggests that interferon therapy works only for enterovirus-associated ME/CFS.<ref name="Brook1993">{{Cite journal | last = Brook | first = M.G. | last2 = Bannister | first2 = B.A. | last3 = Weir | first3 = W.R.C. | date = 1993-09-01 | title = Interferon- Therapy for Patients with Chronic Fatigue Syndrome | url = https://academic.oup.com/jid/article-abstract/168/3/791/870716?redirectedFrom=fulltext|journal=Journal of Infectious Diseases|language=en|volume=168|issue=3 | pages = 791–792|doi=10.1093/infdis/168.3.791|issn=0022-1899}}</ref> In a 1996 study, 30 ME/CFS patients were treated with interferon alpha or placebo in a double-blind crossover trial. The study found that alpha inteferon therapy was particularly effective in the subset of ME/CFS patients who had diminished NK function and normal lymphocyte proliferation.<ref name="See1996">{{Cite journal | last = See | first =D.M. | last2 = Tilles | first2 = J.G. | date = Jan 1996 | title = alpha-Interferon treatment of patients with chronic fatigue syndrome | url = https://www.ncbi.nlm.nih.gov/pubmed/8675231|journal=Immunological Investigations|volume=25|issue=1-2|pages=153–164|issn=0882-0139|pmid=8675231}}</ref>
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