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Interferon
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==Types of interferon== ===Interferon type I=== Type I interferons include the [[interferon alpha|interferon alphas]] (IFN-α or INF-α), [[interferon beta]] (IFN-β or INF-β). Interferon delta (IFN-δ or INF-δ or trophoblast) is also a type I interferon but is not found in humans.<ref name="INF1" /> Excessive, prolonged IFN-I signaling in persistent infections leads to multiple immune dysfunctions. <ref>{{Cite journal | last = Ng | first = Cherie T. | last2 = Snell | first2 = Laura M. | last3 = Brooks | first3 = David G. | last4 = Oldstone | first4 = Michael B.A. | date = 2013-06-12 | title = Networking at the level of host immunity: immune cell interactions during persistent viral infections | url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713852/|journal=Cell host & microbe|volume=13|issue=6 | pages = 652–664|doi=10.1016/j.chom.2013.05.014|issn=1931-3128|pmc=3713852|pmid=23768490}}</ref> ===Interferon type II=== [[Interferon gamma]] (IFN-γ or INF-γ) is the only member of the type II interferon group found in humans, and is produced by [[Lymphocyte|lymphocytes]], a type of white blood cell. Interferon gamma shows antiviral activity, and helps regulate the immune system.<ref name="INF2">{{Cite web | url = http://www.ebi.ac.uk/interpro/entry/IPR002069?q=interferon | title = Interferon gamma (IPR002069) {{!}} InterPro | last = European Bioinformatics Institute | first = | authorlink = European Bioinformatics Institute | date = | website = ebi.ac.uk|archive-url=|archive-date=|access-date=2019-01-24}}</ref> ===Interferon type III=== [[Interferon lambda]] (IFN-λ or INF-λ) is the only member of the recently discovered type III interferon group. In humans the interferon lambda superfamily includes the proteins IFN-lambda1 ([[interleukin 29|IL-29]], interleukin-29), IFN lambda2 ([[interleukin 28A|IL-28A]]), IFN lambda3 ([[interleukin 28B|IL-28B]]) and [[IFNL4]].<ref name="INF3">{{Cite web | url = http://www.ebi.ac.uk/interpro/entry/IPR038326?q=interferon%20type:homologous_superfamily | title = Interferon lambda superfamily (IPR038326) {{!}} InterPro | last = European Bioinformatics Institute | first = | authorlink = | date = | website = European Bioinformatics Institute|language=en|archive-url=|archive-date=|access-date=2019-01-24}}</ref>
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