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Inspiritol
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{{stub}} {{NeedsImage}} '''Inspiritol''' is an experimental drug that aims to treat post-viral illness and respiratory distress.<ref name="inspiritol">{{Cite web | url = https://inspiritol.com/inspiritol | title = New inhaled drug created to treat Respiratory distress & post viral illness | last = | first = | authorlink = | date = | website = Inspiritol®|language=en-US|archive-url=|archive-date=|url-status=|access-date=2021-10-30}}</ref><ref name="wtvy2021">{{Cite web | url = https://www.wtvy.com/prnewswire/2021/10/25/inspiritol-effective-covid-19-long-covid-mecfs-patients/ | title = Inspiritol Effective In COVID-19, Long-COVID And ME/CFS Patients | last = | first = | authorlink = | date = | website = News4|language=en|archive-url=|archive-date=|url-status=|access-date=2021-10-30}}</ref> Inspiritol is both the name of the company company the drug and the name of the drug. Inspiritol has been reported to have been used experimentally on a small number of [[ME/CFS]] patients, long COVID patients, and people with [[influenza|flu]], COPD or asthma.<ref name="inspiritol" /> ==Theory== Inspiritol aims to alter the oral microbiome to reduce levels of bacteria that have previously been linked to inflammation. In a recent small study [[whole genome sequencing]] was used to sample the oral microbiome of patients who tested positive for COVID-19 at an emergency room, fourteen of the patients later developed [[long COVID]]. The study's long COVID patients were found to have changes 19 species of [[bacteria]] in their oral microbiome that were not found in patients without long COVID.<ref name="Hagan2021">{{Cite journal | last = Haran | first = John P. | authorlink = John Haran | last2 = Bradley | first2 = Evan | authorlink2 = Evan Bradley | last3 = Zeamer | first3 = Abigail L. | authorlink3 = | last4 = Cincotta | first4 = Lindsey | authorlink4 = | last5 = Salive | first5 = Marie-Claire | authorlink5 = | last6 = Dutta | first6 = Protiva | authorlink6 = | last7 = Mutaawe | first7 = Shafik | last8 = Anya | first8 = Otuwe | last9 = Meza-Segura | first9 = Mario | date = 2021-10-22 | title = Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID | url = https://insight.jci.org/articles/view/152346|journal=JCI Insight|language=en|volume=6|issue=20|pages=|doi=10.1172/jci.insight.152346|issn=0021-9738|pmc=|pmid=|access-date=|quote=|via=}}</ref><ref name="umassOct2021">{{Cite web | url = https://umassmed.edu/news/news-archives/2021/10/umass-chan-study-finds-association-between-long-covid-symptoms-and-altered-oral-microbiome/ | title = UMass Chan study finds association between long-COVID symptoms and altered oral microbiome | last = Fessendener | first = Jim | authorlink= | date = 2021-10-22 | website = UMass Chan Medical School|language=en|archive-url=|archive-date=|url-status=|access-date=2021-10-30}}</ref> Inspiritol consists of a number of different substances, some of which are believed to have anti-inflammatory, antiviral, or antibacterial effects.<ref name="inspiritol" /> ==Evidence== No clinical trials or case studies of Inspiritol have been published yet. ==Clinicians== Inspiritol has been used in clinical trials by the following ME/CFS researchers: *[[John Salerno]], who helped develop Inspiritol *[[Anna Gill]], University of Massachusetts Chan Medical School *[[Liis Selin|Liisa Selin]], University of Massachusetts Chan Medical School<ref name="inspiritol" /><ref name="wtvy2021" /> ==Risks and safety== Inspiritol remains in clinical trials so the side effects and risks are largely unknown, and it has not yet been given FDA approval. ==Costs and availability== Inspiritol is an inhaled drug which is highly restricted due to not yet being FDA-approved.<ref name="wtvy2021" /> ==See also== *[[Myalgic encephalomyelitis]] *[[Long COVID]] *[[John Salerno]] ==Learn more== *[https://inspiritol.com/# Inspiritol website] ==References == {{Reflist}} [[Category:Potential treatments]] [[Category:Anti-inflammatories]] [[Category:Antivirals]] [[Category:Antibacterials]]
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