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Indoleamine-2,3-dioxygenase 1
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{{stub}} '''Indoleamine-2,3-dioxygenase 1''' or '''IDO''' or '''IDO-1''' is more commonly known as '''IDO1''' is an [[enzyme]] in the [[kynurenine pathway]] involved in the metabolism of the essential amino acid [[tryptophan]] to N-formyl kynurenine.<ref name="gene">{{Cite web | url = https://www.ncbi.nlm.nih.gov/gene/3620 | title = IDO1 indoleamine 2,3-dioxygenase 1 [Homo sapiens (human)] - Gene - NCBI | last = National Center for Biotechnology Information | first = | authorlink = | date = Mar 22, 2020 | website = ncbi.nlm.nih.gov|archive-url=|archive-date=|url-status=|access-date=2020-05-01}}</ref><ref name="Ball2009">{{Cite journal | last = Ball | first = Helen J. | last2 = Yuasa | first2 = Hajime J. | last3 = Austin | first3 = Christopher J.D. | last4 = Weiser | first4 = Silvia | last5 = Hunt | first5 = Nicholas H. | date = 2009-03-01 | title = Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway | url = http://www.sciencedirect.com/science/article/pii/S1357272508000095|journal=The International Journal of Biochemistry & Cell Biology|volume=41|issue=3 | pages = 467β471|doi=10.1016/j.biocel.2008.01.005|issn=1357-2725}}</ref> The gene encoding IDO1 is also sometimes referred to as IDO1.<ref name="gene" /> ==Function== ==ME/CFS== == Notable studies and publications == * 2019, The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS<ref name="Phair2019">{{Cite journal | last = Phair | first = RobertD. | authorlink = Robert Phair | last2 = Davis | first2 = Ronald W. | authorlink2 = Ron Davis | last3 = Kashi | first3 = Alex A. | authorlink3 = Alex Kashi | authorlink4 = | authorlink5 = | authorlink6 = | date = 2019 | title=The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS | url = https://www.mdpi.com/2075-4418/9/3/82|journal=Diagnostics|language=en|volume=9|issue=3 | pages = 82|doi=10.3390/diagnostics9030082|quote=|via=}}</ref> [https://www.mdpi.com/2075-4418/9/3/82/htm (Full text)] ==See also== *[[Indoleamine-2,3-dioxygenase 2]] (IDO2) * [[Metabolic trap]] * [[Kynurenine pathway]] * [[Tryptophan]] * [[Kynurenine]] ==Learn more== *[https://www.ncbi.nlm.nih.gov/gene/3620 IDO1] - National Center for Biotechnology Information ==References== {{reflist}} [[Category:Enzymes]] [[Category:Genes]]
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