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Indoleamine-2,3-dioxygenase
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{{stub}} '''Indoleamine-2,3-dioxygenase''' or '''indolamine-2,3-dioxygenase''' or '''IDO''' is an [[enzyme]] involved in the human body's metabolism of the essential [[amino acid]] [[tryptophan]].<ref name="Bilir2017">{{Cite journal | last = Bilir | first = Cemil | authorlink = | last2 = Sarisozen | first2 = Can | authorlink2 = | date = 2017-07-01 | title = Indoleamine 2,3-dioxygenase (IDO): Only an enzyme or a checkpoint controller? | url = http://www.sciencedirect.com/science/article/pii/S2452336417300201|journal=Journal of Oncological Sciences|language=en|volume=3|issue=2 | pages = 52β56|doi=10.1016/j.jons.2017.04.001|issn=2452-3364|pmc=|pmid=|access-date=|quote=|via=}}</ref><ref name="Phair2019" /> The IDO enzyme degrades (converts) [[tryptophan]] into [[kynurenine]], and this process is strongly linked to the [[Indoleamine-2,3-dioxygenase 1|IDO1]] and [[Indoleamine-2,3-dioxygenase 2|IDO2]] genes.<ref name="Bilir2017" /><ref>{{Cite web | url = https://www.ncbi.nlm.nih.gov/gene/3620 | title = IDO1 indoleamine 2,3-dioxygenase 1 [Homo sapiens (human)] - Gene - NCBI | last = National Center for Biotechnology Information | first = | authorlink = | date = Mar 22, 2020 | website = ncbi.nlm.nih.gov|archive-url=|archive-date=|url-status=|access-date=2020-05-01}}</ref> == Notable studies and publications == * 2019, The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS<ref name="Phair2019">{{Cite journal | last = Phair | first = RobertD. | authorlink = Robert Phair | last2 = Davis | first2 = Ronald W. | authorlink2 = Ron Davis | last3 = Kashi | first3 = Alex A. | authorlink3 = Alex Kashi | authorlink4 = | authorlink5 = | authorlink6 = | date = 2019 | title=The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS | url = https://www.mdpi.com/2075-4418/9/3/82|journal=Diagnostics|language=en|volume=9|issue=3 | pages = 82|doi=10.3390/diagnostics9030082|quote=|via=}}</ref> [https://www.mdpi.com/2075-4418/9/3/82/htm (Full text)] ==Learn more == *2020, IDO and Kynurenine Metabolites in Peripheral and CNS Disorders [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066259/ (Full text)] *2018, Indoleamine 2, 3-dioxygenase regulation of immune response (Review)<ref name="Wu2018">https://doi.org/10.3892/mmr.2018.8537</ref> [https://doi.org/10.3892/mmr.2018.8537 (Full text)] ==See also == *[[Indoleamine-2,3-dioxygenase 1]] (IDO1) *[[Indoleamine-2,3-dioxygenase 2]] (IDO2) * [[Metabolic trap]] hypothesis * [[Tryptophan]] * [[Kynurenine pathway]] * [[ME/CFS Severely Ill, Big Data Study]] * [[Open Medicine Foundation]] ==References == {{Reflist}} [[Category:Enzymes]] [[Category:Genes]] [[Category:Indoles]]
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