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[[File:IanLipkin.jpeg|right]]
[[File:IanLipkin.jpeg|right]]
'''Walter Ian Lipkin''',  or '''W. Ian Lipkin''', MD, is a researcher at Columbia University Mailman School of Public Health in New York City, United States.
'''Walter Ian Lipkin''',  or '''W. Ian Lipkin''', MD, is the John Snow Professor of [[Epidemiology]] at the Mailman School of Public Health at Columbia University and Professor of Neurology and Pathology at the College of Physicians and Surgeons at Columbia University. Lipkin is also Director of the Center for Infection and Immunity, an academic laboratory for microbe hunting in acute and chronic diseases.<ref name="CUProfile" /> Dr. Lipkin traveled to China in 2003 to investigate the SARS outbreak of 2003, and to Saudi Arabia during the MERS outbreak, both coronaviruses.<ref name="CUProfile">{{Cite web | url = https://www.mailman.columbia.edu/people/our-faculty/wil2001 | title = W. Ian Lipkin {{!}} Columbia University Mailman School of Public Health | website = mailman.columbia.edu|access-date=2020-04-22}}</ref>  He traveled again to China in 2020 during the COVID-19 outbreak and contracted the disease himself. <ref>{{Cite web | url = https://www.cnbc.com/2020/03/31/dr-ian-lipkin-coronavirus-shows-need-for-public-health-investment.html | title = Infectious disease expert who has coronavirus says public health can not be overlooked again | last = Stankiewicz | first = Kevin | date = 2020-03-31 | website = CNBC|language=en|access-date=2020-04-22}}</ref>


== Interviews ==
== Talk and interviews ==
*Oct 23, 2021 - [https://youtu.be/DF4mZ9iarxs An Interim Report on Solving the Mysteries of ME/CFS]
*Oct 20, 2017 - [[ME/CFS Alert]] Episode 95 -  [https://www.youtube.com/watch?v=YlS6eZ-Lt2s Interview with Dr. W. Ian Lipkin]
 
*Oct 14, 2017 - [https://www.youtube.com/watch?v=qDOgklnoPvo Solve ME/CFS Initiative Discovery Forum 2017: Presentation of Dr. Ian Lipkin, Columbia University]
 
*Oct 14, 2017 - [https://www.youtube.com/watch?v=Rz9jaz350AI Solve ME/CFS Initiative Discovery Forum 2017: An Interview with Dr. Ian Lipkin by Dr. Zaher Nahle]


*'''Discover Interview: The World's Most Celebrated Virus Hunter, Ian Lipkin'''
*'''Discover Interview: The World's Most Celebrated Virus Hunter, Ian Lipkin'''
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:''Discover - Health & Medicine'' By Grant Delin
:''Discover - Health & Medicine'' By Grant Delin


:"When Ian Lipkin chose a career in infectious diseases, he envisioned hunting for pathogens in daring treks around the world. Though disappointed to learn that modern-day virus hunters work largely from the lab, he still wound up a pioneer."<ref>[http://discovermagazine.com/2012/apr/15-most-celebrated-virus-hunter-ian-lipkin Discover Interview: The World's Most Celebrated Virus Hunter, Ian Lipkin Discover Interview: The World's Most Celebrated Virus Hunter, Ian Lipkin  - Discover - Health & Medicine By Grant Delin]</ref>
:"When Ian Lipkin chose a career in infectious diseases, he envisioned hunting for pathogens in daring treks around the world. Though disappointed to learn that modern-day virus hunters work largely from the lab, he still wound up a pioneer."<ref>{{Cite web | url = http://discovermagazine.com/2012/apr/15-most-celebrated-virus-hunter-ian-lipkin | title = Discover Interview: The World's Most Celebrated Virus Hunter, Ian Lipkin {{!}} DiscoverMagazine.com|website=Discover Magazine|access-date=2019-01-28}}</ref>


*'''[[Forgotten Plague]]''' documentary by [[Ryan Prior]]<ref>http://mecfsdocumentary.com/interviews/</ref>
*'''[[Forgotten Plague]]''' documentary by [[Ryan Prior]]<ref>http://mecfsdocumentary.com/interviews/</ref>


== ME/CFS Research ==
== Notable studies ==
*2017, Fecal metagenomic profiles in subgroups of patients with [[myalgic encephalomyelitis]]/[[chronic fatigue syndrome]] [https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-017-0261-y (FULL TEXT)]<blockquote> Abstract - Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by unexplained persistent [[fatigue]], commonly accompanied by [[cognitive dysfunction]], [[sleep disturbance]], [[orthostatic intolerance]], fever, lymphadenopathy, and [[irritable bowel syndrome]] (IBS). The extent to which the [[gastrointestinal]] [[microbiome]] and peripheral inflammation are associated with [[ME/CFS]] remains unclear. We pursued rigorous clinical characterization, fecal bacterial metagenomics, and plasma immune molecule analyses in 50 ME/CFS patients and 50 healthy controls frequency-matched for age, sex, race/ethnicity, geographic site, and season of sampling. Results: Topological analysis revealed associations between IBS co-morbidity, body mass index, fecal bacterial composition, and bacterial metabolic pathways but not plasma immune molecules. IBS co-morbidity was the strongest driving factor in the separation of topological networks based on bacterial profiles and metabolic pathways. Predictive selection models based on bacterial profiles supported findings from topological analyses indicating that ME/CFS subgroups, defined by IBS status, could be distinguished from control subjects with high predictive accuracy. Bacterial taxa predictive of ME/CFS patients with IBS were distinct from taxa associated with ME/CFS patients without IBS. Increased abundance of unclassified Alistipes and decreased Faecalibacterium emerged as the top [[biomarker]]s of ME/CFS with IBS; while increased unclassified Bacteroides abundance and decreased Bacteroides vulgatus were the top biomarkers of ME/CFS without IBS. Despite findings of differences in bacterial taxa and [[metabolic]] pathways defining ME/CFS subgroups, decreased metabolic pathways associated with unsaturated fatty acid biosynthesis and increased atrazine degradation pathways were independent of IBS co-morbidity. Increased vitamin B6 biosynthesis/salvage and pyrimidine ribonucleoside degradation were the top metabolic pathways in ME/CFS without IBS as well as in the total ME/CFS cohort. In ME/CFS subgroups, symptom severity measures including pain, fatigue, and reduced motivation were correlated with the abundance of distinct bacterial taxa and metabolic pathways. Conclusions: Independent of IBS, ME/CFS is associated with [[dysbiosis]] and distinct bacterial metabolic disturbances that may influence disease severity. However, our findings indicate that dysbiotic features that are uniquely ME/CFS-associated may be masked by disturbances arising from the high prevalence of IBS co-morbidity in ME/CFS. These insights may enable more accurate diagnosis and lead to insights that inform the development of specific therapeutic strategies in ME/CFS subgroups.<ref name="Nagy-Szakal, 2017"/></blockquote>
*2012, A Multicenter Blinded Analysis Indicates No Association between [[ME/CFS|Chronic Fatigue Syndrome/Myalgic Encephalomyelitis]] and either [[Xenotropic murine leukemia virus-related virus|Xenotropic Murine Leukemia Virus-Related Virus]] or Polytropic Murine Leukemia Virus<ref name="Alter, et al, 2012" /> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448165/ (Full Text)]
*2016, [[Cytokine]] network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome.<blockquote> Abstract: "Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 cases, 40 subjects with [[multiple sclerosis]] and 19 normal subjects frequency-matched for age and sex using a 51-plex cytokine assay. Group-specific differences were found for the majority of analytes with an increase in cases of CCL11 (eotaxin), a chemokine involved in eosinophil recruitment. Network analysis revealed an inverse relationship between [[interleukin 1]] receptor antagonist and colony-stimulating factor 1, colony-stimulating factor 2 and [[interleukin]] 17F, without effects on interleukin 1α or interleukin 1β, suggesting a disturbance in interleukin 1 signaling. Our results indicate a markedly disturbed immune signature in the cerebrospinal fluid of cases that is consistent with immune activation in the [[central nervous system]], and a shift toward an allergic or [[T-helper]] type-2 pattern associated with autoimmunity."<ref name="Hornig, 2016"/></blockquote>
*2015, [[ME/CFS|Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)]] is associated with pandemic influenza infection, but not with an adjuvanted pandemic influenza vaccine<ref name="Magnus, 2015" /> - [https://www.ncbi.nlm.nih.gov/pubmed/26475444 (Abstract)]
 
* 2015, Distinct plasma immune signatures in ME/CFS are present early in the course of illness<ref>{{Cite journal | last1 = Hornig | first1 = M | authorlink = Mady Hornig | last2 = Montoya | first2 = JG | authorlink2 = Jose Montoya | last3 = Klimas | first3 = NG | authorlink3 = Nancy Klimas | last4 = Levine | first4 = SM | authorlink4 = Susan Levine | last5 = Felsenstein | first5 = D | authorlink5 = Donna Felsenstein | last6 = Bateman | first6 = L | authorlink6=Lucinda Bateman | last7 = Peterson | first7 = DL | authorlink7 = Daniel Peterson | last8 = Gottschalk | first8 = CG | authorlink8 = Gunnar Gottschalk | last9 = Schultz|first9 = AF | author-link9 = Andrew Schultz | last10 = Che | first10 = X | authorlink10=Xiaoyu Che | last11 = Eddy | first11 = ML | authorlink11=Meredith Eddy | last12 = Komaroff | first12 = AL | authorlink12=Anthony Komaroff | last13 = Lipkin | first13 = WI | authorlink13 = Ian Lipkin | title = Distinct plasma immune signatures in ME/CFS are present early in the course of illness|journal=Science Advances|volume=1|issue=1|page = | date = 2015 | pmid = |doi =10.1126/sciadv.1400121 | url = http://advances.sciencemag.org/content/1/1/e1400121.full}}</ref> - [https://advances.sciencemag.org/content/1/1/e1400121 (Full text)]
*2015, Distinct plasma immune signatures in ME/CFS are present early in the course of illness  [http://advances.sciencemag.org/content/1/1/e1400121.full  FULL TEXT]<blockquote>"Abstract: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an unexplained incapacitating illness that may affect up to 4 million people in the United States alone. There are no validated laboratory tests for diagnosis or management despite global efforts to find biomarkers of disease. We considered the possibility that inability to identify such biomarkers reflected variations in diagnostic criteria and laboratory methods as well as the timing of sample collection during the course of the illness. Accordingly, we leveraged two large, multicenter cohort studies of ME/CFS to assess the relationship of immune signatures with diagnosis, illness duration, and other clinical variables. Controls were frequency-matched on key variables known to affect immune status, including season of sampling and geographic site, in addition to age and sex. We report here distinct alterations in plasma immune signatures early in the course of ME/CFS (n = 52) relative to healthy controls (n = 348) that are not present in subjects with longer duration of illness (n = 246). Analyses based on disease duration revealed that early ME/CFS cases had a prominent activation of both pro- and anti-inflammatory cytokines as well as dissociation of intercytokine regulatory networks. We found a stronger correlation of cytokine alterations with illness duration than with measures of illness severity, suggesting that the immunopathology of ME/CFS is not static. These findings have critical implications for discovery of interventional strategies and early diagnosis of ME/CFS."<ref name="Hornig, 2015"/></blockquote>
*2016, [[Cytokine]] network analysis of cerebrospinal fluid in [[ME/CFS|myalgic encephalomyelitis/chronic fatigue syndrome]]<ref name="Hornig, 2016" /> - [https://www.ncbi.nlm.nih.gov/pubmed/25824300 (Abstract)] 
*2017, Fecal metagenomic profiles in subgroups of patients with [[ME/CFS|myalgic encephalomyelitis/chronic fatigue syndrome]]<ref name="Nagy-Szakal, 2017" /> - [https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-017-0261-y (Full Text)]
*2017, Immune network analysis of cerebrospinal fluid in [[ME/CFS|myalgic encephalomyelitis/chronic fatigue syndrome]] with atypical and classical presentations<ref name="Hornig, 2017" /> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416687/ (Full Text)]
*2018, Insights into [[ME/CFS|myalgic encephalomyelitis/chronic fatigue syndrome]] phenotypes through comprehensive [[metabolomics]]<ref name="Nagy-Szakal, 2018" /> - [https://www.nature.com/articles/s41598-018-28477-9.pdf (Full Text)]


== XMRV ==
== XMRV ==
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''Nature'' By Ewen Callaway
''Nature'' By Ewen Callaway


"A study published today has found no evidence to support research linking the retroviruses XMRV2 and pMLV3 to chronic fatigue syndrome (CFS). The US$2.3-million study, funded by the US [[National Institutes of Health]] (NIH), comes three years after a link between [[XMRV]] and CFS was first reported in Science."<ref>[http://www.nature.com/news/the-scientist-who-put-the-nail-in-xmrv-s-coffin-1.11444 The scientist who put the nail in XMRV's coffin - Nature By Ewen Callaway]</ref>
"A study published today has found no evidence to support research linking the retroviruses XMRV2 and pMLV3 to chronic fatigue syndrome (CFS). The US$2.3-million study, funded by the US [[National Institutes of Health]] (NIH), comes three years after a link between [[XMRV]] and CFS was first reported in Science."<ref name="Alter, et al, 2012" /><ref>[http://www.nature.com/news/the-scientist-who-put-the-nail-in-xmrv-s-coffin-1.11444 The scientist who put the nail in XMRV's coffin - Nature By Ewen Callaway]</ref>


== Lawsuit ==
== Open letters and advocacy ==
On May 18th, 2017, [[Mady Hornig]] brought a lawsuit against the Trustees of Columbia University and Walter Ian Lipkin in NY city court. A jury trial was demanded under Complaint 17 CV 3602. Discriminatory and retaliatory acts (Item 22), blocking of [[ME/CFS]] research (Item 157), misappropriation of funds (Item 225), and many other complaints impacting ME/CFS research.<ref>[https://drive.google.com/drive/folders/0Bzfy9HH9xdjDVVNoWEFxdHNVLUE Case 17 CV 3602 - Mady Hornig, MD vs Trustees of Columbia University and Walter Ian Lipkin, MD - Google PDF]</ref>
=== [[Chilli ME Challenge]] ===
* Jul 1, 2015, [https://www.youtube.com/watch?v=uSNE6JN0SxQ&index=2&list=PLSx6yaUzRhPxb5vqnJaZEpPjj9fKpnVGa Ian Lipkin and Mady Hornig accept] [[Chilli ME Challenge|Chilli ME]] Challenge


=== Media & Science journal coverage ===
=== Open letters ===
*May 23, 2017: [http://www.sciencemag.org/news/2017/05/lawsuit-columbia-university-roils-prominent-chronic-fatigue-syndrome-research-lab Lawsuit at Columbia University roils prominent chronic fatigue syndrome research lab] ''Science Magazine''
* Oct 18, 2018, In response to the Fourth Annual Conference on [[Psychosomatic illness|Psychosomatics]] at Columbia University - ME/CFS is not a psychosomatic [https://www.mailman.columbia.edu/sites/default/files/pdf/mecfs_statement_10-18.pdf illness]<ref>{{Cite web | url = https://www.mailman.columbia.edu/sites/default/files/pdf/mecfs_statement_10-18.pdf | title=Statement to the ME/CFS community | last = Lipkin | first = W. Ian | authorlink=Ian Lipkin | date = Oct 18, 2018 | website = columbia.edu|archive-url=|archive-date=|access-date=Jan 28, 2019|quote=Our studies of blood, cerebrospinal fluid, saliva and feces, using state-of-the-art methods that include microbial gene sequencing, metabolomics, proteomics, and immunological profiling, confirm that patients with ME/CFS have biological abnormalities that cannot be characterized as psychosomatic.<br><br >Committees convened by the National Academies of Sciences, the National Institutes of Health, and the Centers for Disease Control and Prevention have also concluded that ME/CFS is not a psychosomatic disorder.}}</ref>
 
*May 20, 2017: [http://nypost.com/2017/05/20/professor-sues-after-boss-made-her-inspect-his-butt/ Columbia professor says boss made her inspect his butt] ''New York Post''


== Online presence ==
== Online presence ==
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:[[Simmaron Research]] By [[Cort Johnson]]
:[[Simmaron Research]] By [[Cort Johnson]]


:"Ian Lipkin flew to Lake Tahoe this December to fundraise for work he’s doing with the Simmaron Research Foundation. In a talk covering his virus hunting career, the threat of pathogens to humanity, and his work with [[chronic fatigue syndrome]] ([[ME/CFS]]), he dropped a bombshell: he stated that he believes it’s possible to solve ME/CFS in three to five years."<ref>[http://simmaronresearch.com/2015/12/ian-lipkin-three-to-five-years-to-solve-chronic-fatigue-syndrome-mecfs/#sthash.MnUedapw.dpuf Ian Lipkin: Three to Five Years* to Solve Chronic Fatigue Syndrome (ME/CFS) Simmaron Research By: Cort Johnson]</ref>
:"Ian Lipkin flew to Lake Tahoe this December to fund raise for work he’s doing with the Simmaron Research Foundation. In a talk covering his virus hunting career, the threat of pathogens to humanity, and his work with [[chronic fatigue syndrome]] ([[ME/CFS]]), he dropped a bombshell: he stated that he believes it’s possible to solve ME/CFS in three to five years."<ref>{{Cite web | url = http://simmaronresearch.com/2015/12/ian-lipkin-three-to-five-years-to-solve-chronic-fatigue-syndrome-mecfs/ | title = Ian Lipkin: Three to Five Years* to Solve Chronic Fatigue Syndrome (ME/CFS) | last = Johnson | first =Cort | authorlink=Cort Johnson | date = 2015-12-26 | website = Simmaron Research|language=en-US|archive-url=|archive-date=|access-date=2020-05-10}}</ref>


*'''Ian Lipkin Gets ME/CFS Grant – and So Do Others: the [[NIH]] Grants of 2015'''
*'''Ian Lipkin Gets ME/CFS Grant – and So Do Others: the [[NIH]] Grants of 2015'''
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:''Pro-Health'' By [[Cort Johnson]]
:''Pro-Health'' By [[Cort Johnson]]


:"Ian Lipkin gets a big grant and so did some others. (Could the [[IOM]] and [[P2P]] reports have prompted this little flurry of interest?)"<ref>[http://www.prohealth.com/library/showarticle.cfm?libid=21162 Ian Lipkin Gets ME/CFS Grant – and So Do Others: the NIH Grants of 2015 - Pro-Health By: Cort Johnson]</ref>
:"Ian Lipkin gets a big grant and so did some others. (Could the [[IOM]] and [[P2P]] reports have prompted this little flurry of interest?)"<ref>{{Cite web | url = https://www.prohealth.com/library/ian-lipkin-gets-me-cfs-grant-and-so-do-others-the-nih-grants-of-2015-36932 | title = Ian Lipkin Gets ME/CFS Grant – and So Do Others: the NIH Grants of 2015 | last = Johnson | first =Cort | authorlink=Cort Johnson | date = 2015-09-01 | website = Prohealth|language=en-US|archive-url=|archive-date=|access-date=2020-05-10}}</ref>


*'''Drs Lipkin, [[Mady Hornig]] and colleagues discover robust evidence that chronic fatigue syndrome is a biological illness'''
*'''Drs Lipkin, [[Mady Hornig]] and colleagues discover robust evidence that chronic fatigue syndrome is a biological illness'''
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:The [[Microbe Discovery Project]]  
:The [[Microbe Discovery Project]]  


:"Researchers at the Center for Infection and Immunity at Columbia University’s Mailman School of Public Health identified distinct immune changes in patients diagnosed with chronic fatigue syndrome, known medically as myalgic encephalomyelitis (ME/CFS) or [[Systemic Exertion Intolerance Disease]]."<ref>[http://www.microbediscovery.org/blog/archives/1287.html Drs Lipkin, Hornig and colleagues discover robust evidence that chronic fatigue syndrome is a biological illness - The Microbe Discovery Project]</ref>
:"Researchers at the Center for Infection and Immunity at Columbia University’s Mailman School of Public Health identified distinct immune changes in patients diagnosed with chronic fatigue syndrome, known medically as myalgic encephalomyelitis (ME/CFS) or [[Systemic Exertion Intolerance Disease]]."<ref>{{Cite web | url = http://www.microbediscovery.org/blog/archives/1287.html | title = Drs Lipkin, Hornig and colleagues discover robust evidence that chronic fatigue syndrome is a biological illness - The Microbe Discovery Project | last = The Microbe Discovery Project | first = | authorlink = | date = 2015-04-25 | website = web.archive.org|archive-url=https://web.archive.org/web/20160301044855/http://www.microbediscovery.org/blog/archives/1287.html|archive-date=2016-03-01|url-status=dead|access-date=2020-05-10}}</ref>


*2015, [https://www.youtube.com/watch?v=jxwGSgXlJnE Ian Lipkin, Mady Hornig - Chilli M.E. Challenge - YouTube]
*2015, [https://www.youtube.com/watch?v=jxwGSgXlJnE Ian Lipkin, Mady Hornig - Chilli M.E. Challenge - YouTube]
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*[[Mady Hornig]]
*[[Mady Hornig]]
*[[Microbe Discovery Project]]
*[[Microbe Discovery Project]]
 
===== Reports that may have led to grants =====
=== Reports that may have led to grants ===
*[[Institute of Medicine report]] - [[IOM]]
*[[Institute of Medicine report]] - [[IOM]]
*[[Pathways to prevention report]] (P2P) - [[NIH]]
*[[Pathways to prevention report]] (P2P) - [[NIH]]
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== References ==
== References ==
<references>
<references>
<ref name="Hornig, 2015">
<ref name="Alter, et al, 2012">{{Citation | last1 = Alter | first1 = Harvey J. | authorlink1 = | last2 = Mikovits | first2 = Judy A. | authorlink2 = Judy Mikovits | last3 = Switzer | first3 = William M. | authorlink3 = | last4 =Ruscetti | first4 = Francis W. | authorlink4 = | last5 =Lo | first5 = Shyh-Ching | author-link5 = | last6 = Klimas | first6 = Nancy | authorlink6 = Nancy Klimas | last7 = Komaroff | first7 = Anthony L. | authorlink7 = Anthony Komaroff | last8 =Montoya | first8 = Jose G. | authorlink8 = Jose Montoya | last9 =Bateman | first9 = Lucinda| author-link9 = Lucinda Bateman | last10 =Levine | first10 = Susan | authorlink10 = Susan Levine | last11 = Peterson | first11 = Daniel | authorlink11 = Daniel Peterson | last12 = Levin | first12 = Bruce | authorlink12 = Bruce Levin | last13 = Hanson | first13 = Maureen R. | authorlink13 = Maureen Hanson | last14 =  Genfi | first14 = Afia | authorlink14 = | last15 = Bhat | first15 = Meera | authorlink15 = | last16 =  Zheng | first16 = HaoQiang | authorlink16 = | last17 = Wang | first17 = Richard | authorlink17 = | last18 =  Li | first18 = Bingjie | authorlink18 = | last19 = Hung | first19 = Guo-Chiuan | authorlink19 = | last20 =  Lee | first20 = Li Ling | authorlink20 = | last21 = Sameroff | first21 = Stephen | authorlink21 = | last22 = Heneine | first22 = Walid | authorlink22 = | last23 = Coffin | first23 = John | authorlink23 = | last24 = Hornig | first24 = Mady | authorlink24 = Mady Hornig | last25 = Lipkin | first25 = W. Ian | authorlink25 = Ian Lipkin | title = A Multicenter Blinded Analysis Indicates No Association between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus | journal = mBio | volume = 3 | issue = 5 | page = e00266–12 | date = 2012 | pmid = | doi = 10.1128/mBio.00266-12 }}</ref>
{{Citation
<ref name="Hornig, 2016">{{Citation | last1 = Hornig | first1 = M | authorlink1 = | last2 = Gottschalk | first2 = G | authorlink2 = Gunnar Gottschalk | last3 =Peterson | first3 = D | authorlink3 = Daniel Peterson | last4 = Knox | first4 = KK | authorlink4 = | last5 =Schultz | first5 = AF | authorlink5 = | last6 =Eddy | first6 = ML | authorlink6 = | last7 = Che | first7 = X | authorlink7 = | last8 =Lipkin | first8 = WI | authorlink8 = Ian Lipkin | title = Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome. | journal = Molecular Psychiatry | volume = 21 | issue = 2 | page = 261-9 | date = 2016 | doi = 10.1038/mp.2015.29 }}</ref>
| last1   = Hornig                | first1 = M                  | authorlink1 = Mady Hornig
<ref name="Hornig, 2017">{{Citation | last1 = Hornig | first1 = M | authorlink1 = Mady Hornig | last2 = Gottschalk | first2 = G | authorlink2 = Gunnar Gottschalk | last3 =Eddy | first3 = ML | authorlink3 = | last4 =Che | first4 = X | authorlink4 = | last5 =Ukaigwe | first5 = JE | authorlink5 = | last6 = Peterson | first6 = DL | authorlink6 = Daniel Peterson | last7 =Lipkin | first7 = WI | authorlink7 = Ian Lipkin | title =  Immune network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome with atypical and classical presentations | journal = Translational Psychiatry | volume = 7 | issue = 4 | page = | date = 2017 | doi = 10.1038/tp.2017.44 }}</ref>
| last2   = Montoya                  | first2 = JG                    | authorlink2 = Jose Montoya
<ref name="Magnus, 2015">{{Cite journal | last1 = Magnus | first1 = P | authorlink1 = | last2 = Gunnes | first2 = N | authorlink2 = | last3 =Tveito | first3 = K | authorlink3 = | last4 =Bakken | first4 = IJ | authorlink4 = Inger Johanne Bakken | last5 = Ghaderi | first5 = S | authorlink5 = | last6 = Stoltenberg | first6 = C | authorlink6 = | last7 =Hornig | first7 = M | authorlink7 = Mady Hornig | last8 =Lipkin | first8 = WI | authorlink8 = Ian Lipkin | last9 =Trogstad | first9 = L | author-link9 = | last10 = Håberg | first10 = SE | authorlink10 = | title = Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is associated with pandemic influenza infection, but not with an adjuvanted pandemic influenza vaccine | journal = Vaccine | volume = 33 | issue = 46 | date = 2015 | pmid = 26475444 | doi = 10.1016/j.vaccine.2015.10.018 | url= https://www.sciencedirect.com/science/article/pii/S0264410X15014334 | pages = 6173-7}}</ref>
| last3   = Klimas                  | first3 = NG                  | authorlink3 = Nancy Klimas
<ref name="Nagy-Szakal, 2017">{{Citation | last1 = Nagy-Szakal | first1 = Dorottya | authorlink1 = Dorottya Nagy-Szakal | last2 = Williams | first2 = Brent L. | authorlink2 = | last3 =Mishra | first3 = Nischay | authorlink3 = | last4 =Che | first4 = Xiaoyu| authorlink4 = | last5 =Lee | first5 = Bohyun | authorlink5 = | last6 = Bateman | first6 = Lucinda | authorlink6 = Lucinda Bateman | last7 = Klimas | first7 = Nancy G. | authorlink7 = Nancy Klimas | last8 =Komaroff | first8 = Anthony L. | authorlink8 = Anthony Komaroff | last9 = Levine | first9 = Susan | author-link9 = Susan Levine | last10 =Montoya | first10 = Jose G. | authorlink10 = Jose Montoya | last11 = Peterson | first11 = Daniel L. | authorlink11 = Daniel Peterson | last12 = Ramanan | first12 = Devi | authorlink12 = | last13 = Jain | first13 = Komal | authorlink13 = | last14 = Eddy | first14 = Meredith L. | authorlink14 = | last15 = Hornig | first15 = Mady | authorlink15 = Mady Hornig | last16 = Lipkin | first16 = W. Ian | authorlink16 = Ian Lipkin | title = Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome | journal = Microbiome | volume = 5 | issue = 44 | page = | date = 2017 | pmid = | doi = 10.1186/s40168-017-0261-y }}</ref>
| last4   = Levine              | first4 = SM                | authorlink4 = Susan Levine
<ref name="Nagy-Szakal, 2018">{{Citation | last1 = Nagy-Szakal | first1 = Dorottya | authorlink1 = Dorottya Nagy-Szakal | last2 = Barupal | first2 = Dinesh K. | authorlink2 = | last3 =Lee | first3 = Bohyun | authorlink3 = | last4 =Che | first4 = Xiaoyu| authorlink4 = | last5 = Williams | first5 = Brent L. | authorlink5 = | last6 = Kahn | first6 = Ellie J. R. | authorlink6 = | last7 =Ukaigwe | first7 = Joy E. | authorlink7 = | last8 =Bateman | first8 = Lucinda | authorlink8 = Lucinda Bateman | last9 = Klimas | first9 = Nancy G. | author-link9 = Nancy Klimas | last10 = Komaroff | first10 = Anthony L. | authorlink10 = Anthony Komaroff | last11 = Levine | first11 = Susan | authorlink11 = Susan Levine | last12 = Montoya | first12 = Jose G. | authorlink12 = Jose Montoya | last13 = Peterson | first13 = Daniel L. | authorlink13 = Daniel Peterson | last14 = Levin | first14 = Bruce| authorlink14 = Bruce Levin | last15 = Hornig | first15 = Mady | authorlink15 = Mady Hornig | last16 = Fiehn | first16 = Oliver | authorlink16 = | last17 = Lipkin | first17 = W. Ian | authorlink17 = Ian Lipkin | title =  Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics | journal = Scientific Reports | volume = 8 | issue = 1  | page = 10056 | date = 2018 | pmid = | doi = 10.1038/s41598-018-28477-9 }}</ref>
| last5   = Felsenstein                  | first5 = D                | authorlink5 =  
| last6   = Bateman                  | first6 = L                  | authorlink6 = Lucinda Bateman
| last7   = Peterson                | first7 = DL                  | authorlink7 = Daniel Peterson
| last8   = Gottschalk                | first8 = CG      | authorlink8 = Gunnar Gottschalk
| last9   = Schultz                | first9 = AF                  | authorlink9 =
| last10   = Che                | first10 = X      | authorlink10 =  
| last11   = Eddy                | first11 = ML                  | authorlink11 =
| last12   = Komaroff                | first12 = AL          | authorlink12 = Anthony Komaroff
| last13   = Lipkin                | first13 = WI      | authorlink13 = Ian Lipkin  
| title   = Distinct plasma immune signatures in ME/CFS are present early in the course of illness
| journal = Science Advances    | volume = 1  | issue = 1  | page =  
| date   = 2015
| pmid   =  
| doi     = 10.1126/sciadv.1400121
}}
</ref>
<ref name="Hornig, 2016">
{{Citation
| last1   = Hornig                 | first1 = M                   | authorlink1 =  
| last2   = Gottschalk                 | first2 = G                   | authorlink2 = Gunnar Gottschalk  
| last3   = Peterson                 | first3 = D                 | authorlink3 = Daniel Peterson
| last4   = Knox                 | first4 = KK                   | authorlink4 =  
| last5   = Schultz                 | first5 = AF                   | authorlink5 =  
| last6   = Eddy                 | first6 = ML                   | authorlink6 =  
| last7   = Che                 | first7 = X                   | authorlink7 =  
| last8   = Lipkin                 | first8 = WI                   | authorlink8 = Ian Lipkin
| title   = Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome.
| journal = Molecular Psychiatry   | volume = 21 | issue = 2   | page = 261-9
| date   = 2016  
| doi     = 10.1038/mp.2015.29
}}
</ref>
<ref name="Nagy-Szakal, 2017">
{{Citation
| last1   = Nagy-Szakal         | first1 = Dorottya                 | authorlink1 =  
| last2   = Williams             | first2 = Brent L.                 | authorlink2 =  
| last3   = Mishra               | first3 = Nischay                 | authorlink3 =  
| last4   = Che                 | first4 = Xiaoyu                   | authorlink4 =  
| last5   = Lee                 | first5 = Bohyun                   | authorlink5 =  
| last6   = Bateman             | first6 = Lucinda                 | authorlink6 = Lucinda Bateman
| last7   = Klimas               | first7 = Nancy G.                 | authorlink7 = Nancy Klimas  
| last8   = Komaroff             | first8 = Anthony L.               | authorlink8 = Anthony Komaroff
| last9   = Levine               | first9 = Susan                   | authorlink9 = Susan Levine
| last10   = Montoya             | first10 = Jose G.                 | authorlink10 = Jose Montoya
| last11   = Peterson           | first11 = Daniel L.               | authorlink11 = Daniel Peterson
| last12   = Ramanan             | first12 = Devi                   | authorlink12 =  
| last13   = Jain               | first13 = Komal                   | authorlink13 =  
| last14   = Eddy               | first14 = Meredith L.             | authorlink14 =  
| last15   = Hornig             | first15 = Mady                   | authorlink15 = Mady Hornig
| last16   = Lipkin             | first16 = W. Ian                 | authorlink16 = Ian Lipkin
| title   = Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome
| journal = Microbiome   | volume = 5   | issue = 44   | page =  
| date   = 2017
| pmid   =  
| doi     = 10.1186/s40168-017-0261-y
}}
</ref>
</references>
</references>


[[Category:Researchers]]
[[Category:Researchers]]
[[Category:USA researchers]]
[[Category:US researchers]]
[[Category:NIH post-infectious ME/CFS study investigator]]
[[Category:NIH post-infectious ME/CFS study investigator]]

Latest revision as of 13:20, April 2, 2023

IanLipkin.jpeg

Walter Ian Lipkin, or W. Ian Lipkin, MD, is the John Snow Professor of Epidemiology at the Mailman School of Public Health at Columbia University and Professor of Neurology and Pathology at the College of Physicians and Surgeons at Columbia University. Lipkin is also Director of the Center for Infection and Immunity, an academic laboratory for microbe hunting in acute and chronic diseases.[1] Dr. Lipkin traveled to China in 2003 to investigate the SARS outbreak of 2003, and to Saudi Arabia during the MERS outbreak, both coronaviruses.[1] He traveled again to China in 2020 during the COVID-19 outbreak and contracted the disease himself. [2]

Talk and interviews[edit | edit source]

  • Discover Interview: The World's Most Celebrated Virus Hunter, Ian Lipkin
Discover - Health & Medicine By Grant Delin
"When Ian Lipkin chose a career in infectious diseases, he envisioned hunting for pathogens in daring treks around the world. Though disappointed to learn that modern-day virus hunters work largely from the lab, he still wound up a pioneer."[3]

Notable studies[edit | edit source]

XMRV[edit | edit source]

The scientist who put the nail in XMRV's coffin

Nature By Ewen Callaway

"A study published today has found no evidence to support research linking the retroviruses XMRV2 and pMLV3 to chronic fatigue syndrome (CFS). The US$2.3-million study, funded by the US National Institutes of Health (NIH), comes three years after a link between XMRV and CFS was first reported in Science."[5][12]

Open letters and advocacy[edit | edit source]

Chilli ME Challenge[edit | edit source]

Open letters[edit | edit source]

  • Oct 18, 2018, In response to the Fourth Annual Conference on Psychosomatics at Columbia University - ME/CFS is not a psychosomatic illness[13]

Online presence[edit | edit source]

Learn more[edit | edit source]

  • Ian Lipkin: Three to Five Years* to Solve Chronic Fatigue Syndrome (ME/CFS)
Simmaron Research By Cort Johnson
"Ian Lipkin flew to Lake Tahoe this December to fund raise for work he’s doing with the Simmaron Research Foundation. In a talk covering his virus hunting career, the threat of pathogens to humanity, and his work with chronic fatigue syndrome (ME/CFS), he dropped a bombshell: he stated that he believes it’s possible to solve ME/CFS in three to five years."[14]
  • Ian Lipkin Gets ME/CFS Grant – and So Do Others: the NIH Grants of 2015
Pro-Health By Cort Johnson
"Ian Lipkin gets a big grant and so did some others. (Could the IOM and P2P reports have prompted this little flurry of interest?)"[15]
  • Drs Lipkin, Mady Hornig and colleagues discover robust evidence that chronic fatigue syndrome is a biological illness
The Microbe Discovery Project
"Researchers at the Center for Infection and Immunity at Columbia University’s Mailman School of Public Health identified distinct immune changes in patients diagnosed with chronic fatigue syndrome, known medically as myalgic encephalomyelitis (ME/CFS) or Systemic Exertion Intolerance Disease."[16]

See also[edit | edit source]

Reports that may have led to grants[edit | edit source]

References[edit | edit source]

  1. ↑ 1.0 1.1 "W. Ian Lipkin | Columbia University Mailman School of Public Health". mailman.columbia.edu. Retrieved April 22, 2020.
  2. ↑ Stankiewicz, Kevin (March 31, 2020). "Infectious disease expert who has coronavirus says public health can not be overlooked again". CNBC. Retrieved April 22, 2020.
  3. ↑ "Discover Interview: The World's Most Celebrated Virus Hunter, Ian Lipkin | DiscoverMagazine.com". Discover Magazine. Retrieved January 28, 2019.
  4. ↑ http://mecfsdocumentary.com/interviews/
  5. ↑ 5.0 5.1 Alter, Harvey J.; Mikovits, Judy A.; Switzer, William M.; Ruscetti, Francis W.; Lo, Shyh-Ching; Klimas, Nancy; Komaroff, Anthony L.; Montoya, Jose G.; Bateman, Lucinda; Levine, Susan; Peterson, Daniel; Levin, Bruce; Hanson, Maureen R.; Genfi, Afia; Bhat, Meera; Zheng, HaoQiang; Wang, Richard; Li, Bingjie; Hung, Guo-Chiuan; Lee, Li Ling; Sameroff, Stephen; Heneine, Walid; Coffin, John; Hornig, Mady; Lipkin, W. Ian (2012), "A Multicenter Blinded Analysis Indicates No Association between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus", mBio, 3 (5): e00266–12, doi:10.1128/mBio.00266-12
  6. ↑ Magnus, P; Gunnes, N; Tveito, K; Bakken, IJ; Ghaderi, S; Stoltenberg, C; Hornig, M; Lipkin, WI; Trogstad, L; Håberg, SE (2015). "Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is associated with pandemic influenza infection, but not with an adjuvanted pandemic influenza vaccine". Vaccine. 33 (46): 6173–7. doi:10.1016/j.vaccine.2015.10.018. PMID 26475444.
  7. ↑ Hornig, M; Montoya, JG; Klimas, NG; Levine, SM; Felsenstein, D; Bateman, L; Peterson, DL; Gottschalk, CG; Schultz, AF; Che, X; Eddy, ML; Komaroff, AL; Lipkin, WI (2015). "Distinct plasma immune signatures in ME/CFS are present early in the course of illness". Science Advances. 1 (1). doi:10.1126/sciadv.1400121.
  8. ↑ Hornig, M; Gottschalk, G; Peterson, D; Knox, KK; Schultz, AF; Eddy, ML; Che, X; Lipkin, WI (2016), "Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome.", Molecular Psychiatry, 21 (2): 261-9, doi:10.1038/mp.2015.29
  9. ↑ Nagy-Szakal, Dorottya; Williams, Brent L.; Mishra, Nischay; Che, Xiaoyu; Lee, Bohyun; Bateman, Lucinda; Klimas, Nancy G.; Komaroff, Anthony L.; Levine, Susan; Montoya, Jose G.; Peterson, Daniel L.; Ramanan, Devi; Jain, Komal; Eddy, Meredith L.; Hornig, Mady; Lipkin, W. Ian (2017), "Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome", Microbiome, 5 (44), doi:10.1186/s40168-017-0261-y
  10. ↑ Hornig, M; Gottschalk, G; Eddy, ML; Che, X; Ukaigwe, JE; Peterson, DL; Lipkin, WI (2017), "Immune network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome with atypical and classical presentations", Translational Psychiatry, 7 (4), doi:10.1038/tp.2017.44
  11. ↑ Nagy-Szakal, Dorottya; Barupal, Dinesh K.; Lee, Bohyun; Che, Xiaoyu; Williams, Brent L.; Kahn, Ellie J. R.; Ukaigwe, Joy E.; Bateman, Lucinda; Klimas, Nancy G.; Komaroff, Anthony L.; Levine, Susan; Montoya, Jose G.; Peterson, Daniel L.; Levin, Bruce; Hornig, Mady; Fiehn, Oliver; Lipkin, W. Ian (2018), "Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics", Scientific Reports, 8 (1): 10056, doi:10.1038/s41598-018-28477-9
  12. ↑ The scientist who put the nail in XMRV's coffin - Nature By Ewen Callaway
  13. ↑ Lipkin, W. Ian (October 18, 2018). "Statement to the ME/CFS community" (PDF). columbia.edu. Retrieved January 28, 2019. Our studies of blood, cerebrospinal fluid, saliva and feces, using state-of-the-art methods that include microbial gene sequencing, metabolomics, proteomics, and immunological profiling, confirm that patients with ME/CFS have biological abnormalities that cannot be characterized as psychosomatic.

    Committees convened by the National Academies of Sciences, the National Institutes of Health, and the Centers for Disease Control and Prevention have also concluded that ME/CFS is not a psychosomatic disorder.
  14. ↑ Johnson, Cort (December 26, 2015). "Ian Lipkin: Three to Five Years* to Solve Chronic Fatigue Syndrome (ME/CFS)". Simmaron Research. Retrieved May 10, 2020.
  15. ↑ Johnson, Cort (September 1, 2015). "Ian Lipkin Gets ME/CFS Grant – and So Do Others: the NIH Grants of 2015". Prohealth. Retrieved May 10, 2020.
  16. ↑ The Microbe Discovery Project (April 25, 2015). "Drs Lipkin, Hornig and colleagues discover robust evidence that chronic fatigue syndrome is a biological illness - The Microbe Discovery Project". web.archive.org. Archived from the original on March 1, 2016. Retrieved May 10, 2020.

chronic disease a disease or condition that usually lasts for 3 months or longer and may get worse over time. Chronic diseases are long-term (typically incurable and requiring long-term management) but are not necessarily severe.

National Institutes of Health (NIH) - A set of biomedical research institutes operated by the U.S. government, under the auspices of the Department of Health and Human Services.

somatic symptom disorder A psychiatric term to describe an alleged condition whereby a person's thoughts somehow cause physical symptoms. The actual existence of such a condition is highly controversial, due to a lack of scientific evidence. It is related to other psychiatric terms, such as "psychosomatic", "neurasthenia", and "hysteria". Older terms include "somatization", "somatoform disorder", and "conversion disorder". Such terms refer to a scientifically-unsupported theory that claims that a wide range of physical symptoms can be created by the human mind, a theory which has been criticized as "mind over matter" parapsychology, a pseudoscience.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

cytokine any class of immunoregulatory proteins secreted by cells, especially immune cells. Cytokines are small proteins important in cell signaling that modulate the immune system. (Learn more: me-pedia.org)

microbiome The full collection of microscopic organisms (especially bacteria and fungi) which are present in a particular environment, particularly inside the human body.

Centers for Disease Control and Prevention (CDC) - The Centers for Disease Control and Prevention is a U.S. government agency dedicated to epidemiology and public health. It operates under the auspices of the Department of Health and Human Services.

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