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Hydrocortisone
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==Clinical trials in ME/CFS== A 1998 double-blind, randomized, placebo-controlled trial found that low dose hydrocortisone led to significant improvement in subjective scores but concluded that the resulting degree of adrenal suppression precludes its practical use.<ref>{{Cite journal | last = McKenzie | first = R | date = Sep 1998 | title = Low-dose hydrocortisone for treatment of chronic fatigue syndrome: a randomized controlled trial | url = https://www.ncbi.nlm.nih.gov/pubmed/9757853|journal=JAMA|volume=280|issue=12|pages=1061-6|via=}}</ref> In 1999, the Institute of Psychiatry, London, did a randomized crossover trial, in which [[Simon Wessely]] was an author, where low dose hydrocortisone treatments given to patients with [[chronic fatigue syndrome]] were found to reduce [[fatigue scores]] and that 28% of patients in the treatment group had reductions in scores that brought them to or close to normal in the short term.<ref>{{Cite journal | last = Cleare | first = AJ | date = February 1999 | title = Low-dose hydrocortisone in chronic fatigue syndrome: a randomised crossover trial | url = https://www.ncbi.nlm.nih.gov/pubmed/9989716|journal=Lancet|volume=353 | pages = 455-8|via=}}</ref> A 2003 double-blind, randomized, placebo-controlled trial in combination with [[fludrocortisone]], a [[mineralocorticoid]], found no difference in self-reported outcomes.<ref>{{Cite journal | last = Blockmans | first = D | date = Jun 2003 | title = Combination therapy with hydrocortisone and fludrocortisone does not improve symptoms in chronic fatigue syndrome: a randomized, placebo-controlled, double-blind, crossover study | url = https://www.ncbi.nlm.nih.gov/pubmed/12829200|journal=Am J Med|volume=114|issue=9 | pages = 736-41|via=}}</ref>
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