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Human leukocyte antigen genes
(section)
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==ME/CFS== Lande et al. (2020) found two HLA associations that were more common in people with ME/CFS, with 19.2% of ME/CFS patients carrying one of the two HLA associations identified, compared to 12.2% of the control group.<ref name="Lande2020" /> The HLA associations more common in ME/CFS patients were HLA-C*07:04 and HLA-DQB1*03:03.<ref name="Lande2020" /> The 426 ME/CFS patients in the study met the Canadian Consensus Criteria for ME/CFS, except for four who met the International Consensus Criteria for ME.<ref name="Lande2020" /> A small Norwegian trial found patients positive for '''HLA-DQB1*03:03''' and/or '''HLA-C*07:04''' were more likely to respond to [[cyclophosphamide]] than patients without those alleles, 83 vs. 43%.<ref name="Rekeland2020" /> A much larger Norway study the following year by Hajdarevic found further HLA associations in over 400 patients meeting the [[Canadian Consensus Criteria]] for [[ME/CFS]].<ref name="Hajdarevic2021" />
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