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Human leukocyte antigen complex
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{{stub}} The '''Human Leukocyte Antigen complex''' or '''HLA complex''' is a group of proteins that "helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria".<ref name="ghr-primer">{{Cite web | url=https://medlineplus.gov/genetics/ | title = Genetics|website=MedlinePlus|language=en|access-date=2021-11-08}}</ref><ref name="mwdict">{{Cite web | url=https://www.merriam-webster.com/dictionary/human+leukocyte+antigen | title = Definition of HUMAN LEUKOCYTE ANTIGEN|website=Merriam-Webster Dictionary|language=en|access-date=2021-11-08}}</ref> It is the human version of the [[major histocompatibility complex|Major Histocompatibility Complex]] (MHC), which is also found in certain non-human species.<ref name="ghr-primer" /> ==Autoimmune disease== HLA associations in the genes of patients are considered to be a classic indicator that is a disease is autoimmune disease in nature.<ref name="Hajdarevic2021"/> ==ME/CFS== A number of different studies by Mella et al. in [[Norway]] have found associations between HLA genes and ME/CFS patients meeting the [[Canadian Consensus Criteria]], suggesting ME/CFS may be an autoimmune illness.<ref name="Hajdarevic2021">{{Cite journal | last = Hajdarevic | first = Riad | authorlink = Riad Hajdarevic | last2 = Lande | first2 = Asgeir | authorlink2 = Asgeir Lande | last3 = Rekeland | first3 = Ingrid | authorlink3 = Ingrid Rekeland | last4 = Rydland | first4 = Anne | authorlink4 = Anne Rydland | last5 = Strand | first5 = Elin B. | authorlink5 = | last6 = Sosa | first6 = DaisyD. | authorlink6 = | last7 = Creary | first7 = Lisa E | last8 = Mella | first8 = Olav | authorlink8 = Olav Mella | last9 = Egeland | first9 = Torstein | author-link9 = Egeland Torstein | date = 2021-11-01 | title = Fine mapping of the major histocompatibility complex (MHC) in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suggests involvement of both HLA class I and class II loci | url = https://www.sciencedirect.com/science/article/pii/S0889159121005092|journal=Brain, Behavior, and Immunity|language=en|volume=98|issue=|pages=101β109|doi=10.1016/j.bbi.2021.08.219|issn=0889-1591|pmc=|pmid=|access-date=|quote=|via=}}</ref> ==See also== *[[Histamine]] *[[Innate immune system]] *[[Human leukocyte antigen genes]] (HLA genes) ==Learn more== *[https://ghr.nlm.nih.gov/primer/genefamily/hla Histocompatibility complex] - Genetics home reference - US Library of Medicine ==References == {{Reflist}} [[Category:Immunology]]
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