Hashimoto's thyroiditis (hypothyroidism)

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Hashimoto's thyroiditis, also known as Hashimoto's disease, is an autoimmune disease affecting thyroid function.

Signs and symptoms[edit | edit source]

Treatments[edit | edit source]

HLA risk alleles link ME/CFS and Hashimoto's[edit | edit source]

In a large 2020 study, CFS patients with Human Leukocyte Antigen (HLA) risk alleles were found to share the following autoimmune diseases, ordered by frequency:[citation needed]

  1. Hashimoto's thyroiditis/hypothyreosis,
  2. Psoriasis
  3. Rheumatoid arthritis
  4. Alopecia areata
  5. Crohn’s disease or ulcerative colitis

Hashimoto's thyroiditis viral infections commonly associated with ME/CFS[edit | edit source]

Studies suggesting a viral trigger for Hashimoto's thyroiditis and autoimmune thyroiditis (AIT) that are also viruses commonly associated with ME/CFS.

Virologic and Immunologic Evidence Supporting an Association between HHV-6 and Hashimoto's Thyroiditis

Elisabetta Caselli, Maria Chiara Zatelli, Roberta Rizzo, Sabrina Benedetti, Debora Martorelli, Giorgio Trasforini, Enzo Cassai, Ettore C. degli Uberti, Dario Di Luca, Riccardo Dolcetti[1]

2012 Study using fine needle aspirates (FNA) thyroid biopsies found HHV-6 DNA in 28 of 34 (82%) Hashimoto's thyroiditis patients and 3 of 28 (10%) controls.
Association of active human herpesvirus-6 (HHV-6) infection with autoimmune thyroid gland diseases

A Sultanova, M Cistjakovs, S Gravelsina, S Chapenko, S Roga, E Cunskis, Z Nora-Krukle, V Groma, I Ventina, M Murovska[2]

2017 A study comparing the involvement of HHV-6 infection between autoimmune thyroiditis (AIT) patients and healthy controls. Thyroid gland biopsies confirmed active persistent HHV-6 infection in 18 of 44 (41%) AIT patients and 1 of 17 (6%) healthy controls.
Study of Epstein–Barr virus serological profile in Egyptian patients with Hashimoto’s thyroiditis: A case-control study

Samir Naeim Assaad, Marwa Ahmed Meheissen, Eman Tayae Elsayed, Saher N. Alnakhal, Tarek M. Salema[3]

2020 This study included 60 Hashimoto's thyroiditis patients and 60 healthy controls. Epstein-Barr virus (EBV) Early Antigen (EA) was positive in 20 of 60 (33%) HT patients and 4 of 60 (7%) healthy controls, indicating a higher prevalence of active EBV in Hashimoto patients.

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. Caselli, Elisabetta; Zatelli, Maria Chiara; Rizzo, Roberta; Benedetti, Sabrina; Martorelli, Debora; Trasforini, Giorgio; Cassai, Enzo; degli Uberti, Ettore C.; Di Luca, Dario (October 4, 2012). "Virologic and Immunologic Evidence Supporting an Association between HHV-6 and Hashimoto's Thyroiditis". PLoS Pathogens. 8 (10). doi:10.1371/journal.ppat.1002951. ISSN 1553-7366. PMC 3464215. PMID 23055929.
  2. Sultanova, A.; Cistjakovs, M.; Gravelsina, S.; Chapenko, S.; Roga, S.; Cunskis, E.; Nora-Krukle, Z.; Groma, V.; Ventina, I.; Murovska, M. (January 2017). "Association of active human herpesvirus-6 (HHV-6) infection with autoimmune thyroid gland diseases". Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases. 23 (1): 50.e1–50.e5. doi:10.1016/j.cmi.2016.09.023. ISSN 1469-0691. PMID 27693656.
  3. Assaad, Samir Naeim; Meheissen, Marwa Ahmed; Elsayed, Eman Tayae; Alnakhal, Saher N.; Salem, Tarek M. (March 12, 2020). "Study of Epstein–Barr virus serological profile in Egyptian patients with Hashimoto's thyroiditis: A case-control study". Journal of Clinical & Translational Endocrinology. 20. doi:10.1016/j.jcte.2020.100222. ISSN 2214-6237. PMC 7090364. PMID 32215255.