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Harvard ME/CFS Collaborative Research Center
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==Research project== The research focii for this new center are: *'''to collect molecular data on muscle and other tissues affected by [[ME/CFS]]''' :This will include comparing patient muscle biopsies to controls, "examining genomics, proteomics, and ultrastructural analysis". This aims to help uncover the etiology of [[post-exertional malaise]]. This aims to test the hypothesis that "the inflammation-related recovery mechanisms in ME/CFS patients are dysfunctional, and that this delays recovery from post-stress". *'''investigating neurological symptoms of [[brain fog]] and [[circadian rhythm]]s''' :This will involve the testing of hypotheses related to [[microglia|microglial cell]] activation, [[vagus nerve]] signaling, and disrupted [[autonomic]] and [[metabolic]] functioning in the [[central nervous system]]. The very advanced MGH/HMS [[Neutology_of_ME/CFS#Brainimaging|brain imaging]] at the [[Martinos Center for Biomedical Imaging]] will be used. *'''to research the cardiopulmonary problems contributing to [[fatigue]] in [[ME/CFS]]''' :This will use the [[iCPET]] Cardiopulmonary Laboratory at the Brigham and Women's Hospital, Boston. Exploring the "very specific findings that are seen in ME/CFS patients" to help understand the autonomic dysregulation in ME/CFS, its effects, and its contribution to [[postural orthostatic tachycardia syndrome]] (POTS). *'''to explore [[plasma]] repository samples of patients undergoing [[exercise]] stresses''' :This will improve understanding of the proteomics and metabolomics in patients.<ref name="about">{{Cite web | url = http://endmecfs.mgh.harvard.edu/mesmerize/about/ | title = About the ME/CFS Collaboration | last = Harvard ME/CFS Collaboration | first = | authorlink = Harvard ME/CFS Collaborative Research Center | date = 2019 | website = |language=en-US|archive-url=|archive-date=|url-status=|access-date=2019-09-09}}</ref>
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