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HPV vaccine
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==Notable studies and scientific publications== *2007, HPV vaccination and risk of chronic fatigue syndrome/myalgic encephalomyelitis: a nationwide register-based study from Norway<ref name="Fiering2007">{{Cite journal | last = Feiring | first = Berit | authorlink = | last2 = Laake | first2 = Ida | authorlink2 = | last3 = Bakken | first3 = Inger Johanne | authorlink3 = Inger Johanne Bakken | last4 = Greve-Isdahl | first4 = Margrethe | authorlink4 = | last5 = Wyller | first5 = Vegard Bruun | authorlink5 = Vegard Bruun Wyller | last6 = Håberg | first6 = Siri E. | authorlink6 = | last7 = Magnus | first7 = Per | last8 = Trogstad | first8 = Lill | date = 2017-07-24 | title = HPV vaccination and risk of chronic fatigue syndrome/myalgic encephalomyelitis: A nationwide register-based study from Norway| url = http://www.sciencedirect.com/science/article/pii/S0264410X17308083|journal=Vaccine|language=en|volume=35|issue=33 | pages = 4203–4212|doi=10.1016/j.vaccine.2017.06.031|issn=0264-410X|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.sciencedirect.com/science/article/pii/S0264410X17308083 (Full text)] - '''quadrivalent vaccine''' *2013, Bivalent human papillomavirus vaccine and the risk of fatigue syndromes in girls in the UK<ref name="Donegan2013">{{Cite journal | last = Donegan | first = Katherine | authorlink = | last2 = Beau-Lejdstrom | first2 = Raphaelle | authorlink2 = | last3 = King | first3 = Bridget | authorlink3 = | last4 = Seabroke | first4 = Suzie | authorlink4 = | last5 = Thomson | first5 = Andrew | authorlink5 = | last6 = Bryan | first6 = Philip | authorlink6 = | date = 2013-10-09 | title = Bivalent human papillomavirus vaccine and the risk of fatigue syndromes in girls in the UK| url = http://www.sciencedirect.com/science/article/pii/S0264410X13011158|journal=Vaccine|language=en|volume=31|issue=43 | pages = 4961–4967|doi=10.1016/j.vaccine.2013.08.024|issn=0264-410X|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [http://qna.files.parliament.uk/qna-attachments/773017/original/MHRA%20CPRD%20study%20HPV%20and%20CFS.pdf (Full text)] - '''bivalent vaccine''' *2014, Postural Orthostatic Tachycardia With Chronic Fatigue After HPV Vaccination as Part of the “Autoimmune/Auto-inflammatory Syndrome Induced by Adjuvants”: Case Report and Literature Review<ref name="Tomljenovic2014">{{Cite journal | last = Tomljenovic | first = Lucija | last2 = Colafrancesco | first2 = Serena | last3 = Perricone | first3 = Carlo | last4 = Shoenfeld | first4 = Yehuda | date = 2014-01-01 | title = Postural Orthostatic Tachycardia With Chronic Fatigue After HPV Vaccination as Part of the “Autoimmune/Auto-inflammatory Syndrome Induced by Adjuvants”: Case Report and Literature Review | url =https://doi.org/10.1177/2324709614527812|journal=Journal of Investigative Medicine High Impact Case Reports|language=en|volume=2|issue=1 | pages = 2324709614527812|doi=10.1177/2324709614527812|issn=2324-7096|pmc = 4528866|pmid=26425598}}</ref> - [https://journals.sagepub.com/doi/full/10.1177/2324709614527812 (Full text)] *2015, Is Chronic Fatigue Syndrome/Myalgic Encephalomyelitis a Relevant Diagnosis in Patients with Suspected Side Effects to Human Papilloma Virus Vaccine?<ref name="Brinth2015">{{Cite journal | last = Brinth | first = Louise | authorlink = | last2 = Pors | first2 = Kirsten | authorlink2 = | last3 = Hoppe | first3 = Anna AG | authorlink3 = | last4 = Badreldin | first4 = Iman | authorlink4 = | last5 = Mehlsen | first5 = Jesper | authorlink5 = Jesper Mehlsen | date = 2015-06-15 | title = Is Chronic Fatigue Syndrome/Myalgic Encephalomyelitis a Relevant Diagnosis in Patients with Suspected Side Effects to Human Papilloma Virus Vaccine?| url = https://medcraveonline.com/IJVV/IJVV-01-00003.pdf | journal=International Journal of Vaccines & Vaccination|language=en|volume=1|issue=1 | pages = 00003|doi=10.15406/ijvv.2015.01.00003|issn=2470-9980|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.researchgate.net/profile/Louise_Brinth/publication/283420612_Is_Chronic_Fatigue_SyndromeMyalgic_Encephalomyelitis_a_Relevant_Diagnosis_in_Patients_with_Suspected_Side_Effects_to_Human_Papilloma_Virus_Vaccine/links/5842e9b108ae8e63e623c09c/Is-Chronic-Fatigue-Syndrome-Myalgic-Encephalomyelitis-a-Relevant-Diagnosis-in-Patients-with-Suspected-Side-Effects-to-Human-Papilloma-Virus-Vaccine.pdf (Full text)] - '''quadrivalent vaccine''' *2018, Autonomic dysfunction and HPV immunization: an overview<ref name="Blitshteyn2018">{{Cite journal | last = Blitshteyn | first = Svetlana | authorlink = | last2 = Brinth | first2 = Louise | authorlink2 = | last3 = Hendrickson | first3 = Jeanne E. | authorlink3 = | last4 = Martinez-Lavin | first4 = Manuel | authorlink4 = | date = Dec 2018 | title = Autonomic dysfunction and HPV immunization: an overview | url =https://link.springer.com/article/10.1007/s12026-018-9036-1?fbclid=IwAR2r7ow4f_F4mA2VX6EWC12rZusJ939E7wmQwDT9QxxoCvpI3WP798UaVzk|journal=Immunologic Research|volume=66|issue=6 | pages = 744–754|doi=10.1007/s12026-018-9036-1|issn=1559-0755|pmc=|pmid=30478703|access-date=|quote=|via=}}</ref> - [https://siksik.org/wp-content/uploads/vaccins/docksci.com_autonomic-dysfunction-and-hpv-immunization-an-over.pdf (Full text)] - '''all types of vaccine''' *2018, [[Dysautonomia|Autonomic dysfunction]] and HPV immunization: an overview.<ref name="Blitshetyn2018">{{Cite journal | last = Blitshetyn | first = Svetlana | last2 = Brinth | first2 = Louise | last3 = Hendrickson | first3 = Jeanne E. | last4 = Martinez-Lavin | first4 = Manuel | date = 2018-11-27 | title = Autonomic dysfunction and HPV immunization: an overview | url =https://www.ncbi.nlm.nih.gov/pubmed/30478703|journal=Immunologic Research|doi=10.1007/s12026-018-9036-1|issn=1559-0755|pmid=30478703}}</ref> ([[pubmed:30478703|ABSTRACT]])<blockquote>This article reviews the case series reported from several countries describing patients with suspected severe side effects to the HPV vaccines. The described [[symptom clusters]] are remarkably similar and include [[Chronic fatigue|disabling fatigue]], [[headache]], widespread [[pain]], [[fainting]], [[Gastrointestinal system|gastrointestinal]] dysmotility, [[limb weakness]], memory impairment episodes of [[altered awareness]], and [[abnormal movements]]. This constellation of symptoms and signs has been labeled with different diagnoses such as [[complex regional pain syndrome]] (CRPS), [[postural orthostatic tachycardia syndrome]] (POTS), [[Small fiber peripheral neuropathy|small fiber neuropathy]] (SFN), [[ME/CFS|myalgic encephalomyelitis/chronic fatigue syndrome]] (ME/CFS), or [[fibromyalgia]]. It is known that [[Autoimmune disease|autoimmunity]] and [[autoantibodies]] are present in a subset of patients with CRPS, POTS, SFN, ME/CFS, and fibromyalgia. This article proposes that vaccine-triggered, [[immune-mediated autonomic dysfunction]] could lead to the development of de novo [[post-HPV vaccination syndrome]] possibly in [[genetically susceptible]] individuals. Being cognizant that a temporal relationship between vaccination and symptom onset does not necessarily equate to causality, mounting evidence of case series calls for well-designed case-control studies to determine the prevalence and possible causation between these symptom clusters and HPV vaccines. Since [[personalized medicine]] is gaining momentum, the use of [[adversomics]] and [[pharmacogenetics]] may eventually help identify individuals who are predisposed to HPV vaccine adverse events.<ref name="Blitshetyn2018" /></blockquote> *2021, EMA's mishandling of an investigation into suspected serious neurological harms of HPV vaccines<ref name="Gotzscheletter2021">http://dx.doi.org/10.1136/bmjebm-2020-111470</ref> - [http://dx.doi.org/10.1136/bmjebm-2020-111470 (Full text)]
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