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Glutamate receptor, ionotropic, kinase 2
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{{stub}} '''Glutamate receptor, ionotropic, kinase 2''' or '''Glutamate Ionotropic Receptor Kainate Type Subunit 2''' or '''GRIK2'''.<ref name="genecards">{{Cite web | website=Gene cards|access-date=2022-04-01 | url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=GRIK2&keywords=GRIK2 | title = GRIK2 Gene card}}</ref><ref name="Smith2011" /> ===Other names=== *GluK2 *GLUR6 *MRT6 *Glutamate Receptor Ionotropic, Kainate 2 *Excitatory Amino Acid Receptor 4 *EAA4 *Glutamate Receptor 6 *GluR-6<ref name="genecards" /> ==Function == The glutamate receptors are the main excitatory neurotransmitter receptors in the human brain, and a variety of different GRIK2 gene mutations are associated with different neurodevelopment, neurological and psychiatric conditions.<ref>{{Cite web | url = https://www.ncbi.nlm.nih.gov/gene/2898 | title = GRIK2 glutamate ionotropic receptor kainate type subunit 2 [Homo sapiens (human)] - Gene | last = | first = | authorlink = | date = 2022-02-06 | website = National Center for Biotechnology Information|archive-url=|archive-date=|url-status=|access-date=2022-03-31}}</ref> ==ME/CFS== A small study by Smith et al. (2011) found people with the G allele of rs2247215 (GRIK2) were more likely to have [[chronic fatigue syndrome]], and CFS patientz had decreased GRIK2 expression patients.<ref name="Smith2011" /> ==Notable studies == *2011, Convergent Genomic Studies Identify Association of GRIK2 and NPAS2 with Chronic Fatigue Syndrome<ref name="Smith2011">{{Cite journal | title = Convergent Genomic Studies Identify Association of GRIK2 and NPAS2 with Chronic Fatigue Syndrome | date = 2011 | url=https://www.karger.com/Article/FullText/326692|journal=Neuropsychobiology|volume=64|issue=4 | pages = 183β194 | last = Smith | first = Alicia K. | last2 = Fang | first2 = Hong | last3 = Whistler | first3 = Toni | last4 = Unger | first4 = Elizabeth R. | last5 = Rajeevan | first5 = Mangalathu S.|language=english|doi=10.1159/000326692|pmc=PMC3701888|pmid=21912186|issn=0302-282X}}</ref> - [https://doi.org/10.1159/000326692 (Full text)] ==See also == ==Learn more == *[https://www.genecards.org/cgi-bin/carddisp.pl?gene=GRIK2&keywords=GRIK2 GRIK2] - Gene cards ==References == {{Reflist}} [[Category:Genes]] [[Category:Enzymes]]
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