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Genetics of chronic fatigue syndrome
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=== Utah Population Database study === A 2011 study by Albright et al showed evidence of a heritable contribution to [[chronic fatigue syndrome]] (CFS).<ref>{{Cite journal | title = Evidence for a heritable predisposition to Chronic Fatigue Syndrome | date = 2011-05-27| url = https://pubmed.ncbi.nlm.nih.gov/21619629/|journal=BMC neurology|volume=11| pages=62 | last = Albright | first = Frederick | last2 = Light | first2 = Kathleen | last3 = Light | first3 = Alan | last4 = Bateman | first4 = Lucinda | last5 = Cannon-Albright | first5 = Lisa A.|doi=10.1186/1471-2377-11-62|pmc=3128000|pmid=21619629|issn=1471-2377}}</ref> Using the extensive records of the Utah Population Database (UPDB), the study "shows clear evidence of significant excess familial clustering and significantly elevated risks for [[Chronic fatigue syndrome|CFS]] among first, second, and third degree relatives of CFS cases. The results strongly support a genetic contribution to predisposition to CFS as it is currently defined and diagnosed by clinicians in Utah." Increased outbreak rates in first degree relatives are not automatically assumed to be genetic because the first degree relatives often share the same lifestyle and environment. However, a significantly increased incidence (95% confidence interval) in second and third degree relatives strongly indicated a genetic contribution to CFS, given the much lower likelihood of these relatives sharing common risks and environments.<ref>{{Cite journal | title = Evidence for a heritable predisposition to Chronic Fatigue Syndrome | date = 2011-05-27| url = https://pubmed.ncbi.nlm.nih.gov/21619629/|journal=BMC neurology|volume=11| pages=62 | last = Albright | first = Frederick | last2 = Light | first2 = Kathleen | last3 = Light | first3 = Alan | last4 = Bateman | first4 = Lucinda | last5 = Cannon-Albright | first5 = Lisa A.|doi=10.1186/1471-2377-11-62|pmc=3128000|pmid=21619629|issn=1471-2377}}</ref> [[File:Genetic Relationship graph.png|center|Albright,2011 study]]
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