Gene expression

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Upregulated genes in ME/CFS in one study
Author: Sweetman et al. Current Research Provides Insight into the Biological Basis and Diagnostic Potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Diagnostics 2019 9(3) 73. License: CC-BY-4.0

The National Center for Biotechnology Information at the US National Institutes of Health (NIH) defines gene expression as "the phenotypic manifestation of a gene or genes by the processes of genetic transcription and genetic translation."[1] Gene expression takes place in two stages. The first is transcription: the base sequence on DNA is copied to a molecule of mRNA. Next, translation: the mRNA molecule leaves the cell nucleus for the cytoplasm and specifies the particular amino acids that will make up individual proteins in the process of protein synthesis.[1]

Gene expression analysis examines patterns of gene expression in transcription, whether under specific conditions or in certain kinds of cells.[1]

Notable studies[edit | edit source]

  • 2009, A gene signature for post-infectious chronic fatigue syndrome[2]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. ↑ 1.0 1.1 1.2 "Gene Expression". ncbi.nlm.nih.gov. Retrieved January 31, 2019.
  2. ↑ Gow, John W; Hagan, Suzanne; Herzyk, Pawel; Cannon, Celia; Behan, Peter O; Chaudhuri, Abhijit (June 25, 2009). "A gene signature for post-infectious chronic fatigue syndrome". BMC Medical Genomics. 2: 38. doi:10.1186/1755-8794-2-38. ISSN 1755-8794. PMC 2716361. PMID 19555476.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

National Institutes of Health (NIH) - A set of biomedical research institutes operated by the U.S. government, under the auspices of the Department of Health and Human Services.

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