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Fucosyltransferase 2 enzyme
(section)
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==Disease risk== Non-secretors may have an increased risk of [[Crohn's disease]]<ref>[http://www.ncbi.nlm.nih.gov/pubmed/20570966 Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.] Hum Mol Genet. 2010 Sep 1;19(17):3468-76. doi: 10.1093/hmg/ddq248. Epub 2010 Jun 22.</ref> and [[diabetes#Type_1|type 1 diabetes]],<ref>[http://www.ncbi.nlm.nih.gov/pubmed/22025780 FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection], Diabetes. 2011 Nov;60(11):3081-4. doi: 10.2337/db11-0638.</ref> but a decreased risk of [[norovirus]]<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680586/ The G428A Nonsense Mutation in FUT2 Provides Strong but Not Absolute Protection against Symptomatic GII.4 Norovirus Infection] PLoS ONE. 2009; 4(5): e5593. Published online 2009 May 18. doi: 10.1371/journal.pone.0005593</ref> and [[helicobacter pylori]]<ref>[http://www.ncbi.nlm.nih.gov/pubmed/19706747 Fut2-null mice display an altered glycosylation profile and impaired BabA-mediated Helicobacter pylori adhesion to gastric mucosa], Glycobiology. 2009 Dec;19(12):1525-36. doi: 10.1093/glycob/cwp131. Epub 2009 Aug 25.</ref> infection.
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