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Folate
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==Deficiency== Deficiency of either folate or [[Vitamin B12]] can lead to [[Anemia#Megaloblastic anemia|megaloblastic anemia]]. Deficiency is associated with increased blood [[homocysteine]] and an increased risk of cardiovascular disease. Folate is essential for [[brain]] development and function. However, high doses of folic acid may cause long-term issues as it is not fully converted to the folate form naturally found in the human diet, and the unconverted amount may act as a competitive inhibitor of folate. (Methylfolate is more advisable as a supplement for long-term use.<ref>{{Cite web | url=https://www.healthline.com/nutrition/folic-acid-vs-folate | title = Folic Acid vs Folate β What's the Difference? | last = | first = | date = |website=|archive-url=|archive-date=|url-status=|access-date=}}</ref>)
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