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[[Category:ME/CFS Images]]
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== Licensing ==
== Licensing ==
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Latest revision as of 00:48, December 18, 2020

Summary[edit | edit source]

Title: (or description)[edit | edit source]

Functional analysis of SNPs identified three main clusters of pathways as sharing at least 30% SNP related genes.

  • Immune-related SNPs: Cytokine Signaling in Immune System pathway; includes other immune-related pathways such as interferon signaling, autoimmune responses, and T-cell receptor signaling.
  • Hormone-related SNPs: Nuclear-Receptors Meta-Pathway and includes hormone related pathways such as steroid hormone, estrogen, and androgen biosynthesis, glucuronidation, and the pregnane x receptor pathway.
  • Metabolism-related SNPs: Pathways in Cancer, however, closer inspection shows many metabolic processes such as enzyme reactions (protein kinase A, calcium and calmodulin signaling), and G proteins signaling which regulate metabolic enzymes, which are all involved in the regulation of glycogen, sugar and lipid metabolism.

Author: (or citation)[edit | edit source]

Perez M, Juandoo R, Hilton K, Del Alamo A, Gemayel K, Klimas NG, Craddock TJA, Nathanson L (2019). Front. Pediatr. 7(206). doi: 10.3389/fped.2019.00206

Source: (e.g. internet address)[edit | edit source]

Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study Figure 1.

Other information:[edit | edit source]

Pathway overlap networks in ME/CFS.
Pathways identified via over-representation analysis (nodes) connected by shared genes with SNPs (edges). Upper panel gives total number of SNPs per pathway and likelihood of annotation (p-value). Lower panel shows pathways most affected by deleterious SNPs.

See also[edit | edit source]

Licensing[edit | edit source]

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Date/TimeThumbnailDimensionsUserComment
current20:50, September 29, 2020Thumbnail for version as of 20:50, September 29, 20201,036 × 1,339 (833 KB)Notjusttired (talk | contribs)==== Title: (or description) ==== '''Functional analysis of SNPs identified three main clusters of pathways as sharing at least 30% SNP related genes.''' * '''Immune-related SNPs''': Cytokine Signaling in Immune System pathway; includes other immune-re...

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