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File:Genetics ME-CFS-Perez-Klimas-2019.jpg
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== Summary == ==== Title: (or description) ==== '''Functional analysis of SNPs identified three main clusters of pathways as sharing at least 30% SNP related genes.''' * '''Immune-related SNPs''': Cytokine Signaling in Immune System pathway; includes other immune-related pathways such as interferon signaling, autoimmune responses, and T-cell receptor signaling. * '''Hormone-related SNPs''': Nuclear-Receptors Meta-Pathway and includes hormone related pathways such as steroid hormone, estrogen, and androgen biosynthesis, glucuronidation, and the pregnane x receptor pathway. * '''Metabolism-related SNPs''': Pathways in Cancer, however, closer inspection shows many metabolic processes such as enzyme reactions (protein kinase A, calcium and calmodulin signaling), and G proteins signaling which regulate metabolic enzymes, which are all involved in the regulation of glycogen, sugar and lipid metabolism. ==== Author: (or citation) ==== Perez M, Juandoo R, Hilton K, Del Alamo A, Gemayel K, Klimas NG, Craddock TJA, Nathanson L (2019). Front. Pediatr. 7(206). doi: 10.3389/fped.2019.00206 ==== Source: (e.g. internet address) ==== [https://doi.org/10.3389/fped.2019.00206 Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study] Figure 1. ==== Other information: ==== Pathway overlap networks in ME/CFS. <br > Pathways identified via over-representation analysis (nodes) connected by shared genes with SNPs (edges). Upper panel gives total number of SNPs per pathway and likelihood of annotation (p-value). Lower panel shows pathways most affected by deleterious SNPs. ===See also === *[[Genetics of chronic fatigue syndrome]] *[[ME/CFS Gene Study]] [[Category:Images with annotations]] [[Category:ME/CFS images]] [[Category:Abnormal findings]] == Licensing == {{CC-by-4.0}}
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