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Fibromyalgia
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==Prevalence== An estimated 4 million people in the US<ref name="FibroBasics" /> and 2-5% of the world population have fibromyalgia (Clauw et al, 2011). Fibromyalgia is the second most common rheumatic disorder behind [[osteoarthritis]]<ref name="ScienceOfFibro">{{Cite journal | last = Clauw | first = Daniel J. | author-link = Daniel Clauw | last2 = Arnold | first2 = Lesley M. | authorlink2 = | last3 = McCarberg | first3 = Bill H. | date = Sep 2011 | title = The Science of Fibromyalgia| url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258006/|journal=Mayo Clinic Proceedings|volume=86|issue=9 | pages = 907β911|doi=10.4065/mcp.2011.0206|issn=0025-6196|pmc=3258006|pmid=21878603|access-date=|quote=|via=}}</ref> and is considered by many pain experts to be a [[central nervous system]] disorder which is most often lifelong<ref name="Clauw2018">{{Cite journal | last = Harte | first = Steven E. | author-link = | last2 = Harris | first2 = Richard E. | authorlink2 = | last3 = Clauw | first3 = Daniel J. | authorlink3 = Daniel Clauw | date = 2018 | title = The neurobiology of central sensitization | url =https://onlinelibrary.wiley.com/doi/abs/10.1111/jabr.12137|journal=Journal of Applied Biobehavioral Research|language=en|volume=23|issue=2| pages = e12137|doi=10.1111/jabr.12137|issn=1751-9861|pmc=|pmid=|access-date=|quote=|via=}}</ref> that is not fatal.<ref name="wm">{{Cite web | url = https://www.womenshealth.gov/a-z-topics/fibromyalgia | title = Fibromyalgia | last = | first = | authorlink = | date = | website = Office on Women's Health|archive-url=|archive-date=|url-status=|access-date=2021-12-06}}</ref> It is occurs in women, men, children, and all ethnic groups. Fibromyalgia is often seen in families and most commonly diagnosed in middle aged people, and prevalence increases with age.<ref name="CDC-complications" /><ref name="ScienceOfFibro" /> FM is a [[female predominant diseases|female predominant disease]], diagnosed with female:male of between 7:1 and 1.5:1, depending on the criteria used.<ref name="ACR1990" /><ref name="excerpt2" /><ref name="ACR2010" /><ref name="excerpt" /><ref name="medscape" /> See: [[Fibromyalgia#American College of Rheumatology (ACR) Criteria|Fibromyalgia (''American College of Rheumatology (ACR) Criteria'')]]. A September 2018 study by Wolfe et al. found fewer women and more men are diagnosed under the 2010/11 criteria<ref name="Wolfe2018" /> (this criterion further updated in 2016<ref name="2016revision">{{Cite journal | date = 2016-12-01 | title = 2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria| url = https://www.sciencedirect.com/science/article/pii/S0049017216302086|journal=Seminars in Arthritis and Rheumatism|language=en|volume=46|issue=3 | pages = 319β329|doi=10.1016/j.semarthrit.2016.08.012|issn=0049-0172}}</ref>).<blockquote>What we did not find in our unbiased CritFM samples was 9:1 female to male fibromyalgia ratios that are widely described by expert sources [11β13]. We believe that such findings only occur in the presence of selection bias or biased ascertainment.<ref name="Wolfe2018" /></blockquote><blockquote>As unbiased epidemiological studies show only a small increase in the female to male sex ratio (~1.5:1) as opposed to the observed ratio in clinical studies of 9:1, we believe that the over-identification of fibromyalgia in women and the consequent under-identification of men is the result of bias.<ref name="Wolfe2018">{{Cite journal | last = Wolfe | first = Frederick | last2 = Walitt | first2 = Brian | last3 = Perrot | first3 = Serge | last4 = Rasker | first4 = Johannes J. | last5 = HΓ€user | first5 = Winfried | date = 2018-09-13 | title = Fibromyalgia diagnosis and biased assessment: Sex, prevalence and bias |url =https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203755|journal=PLOS ONE|language=en|volume=13|issue=9| pages = e0203755|doi=10.1371/journal.pone.0203755|issn=1932-6203|pmc=|pmid=30212526|via=}}</ref></blockquote>
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